Article
Plant Sciences
Mohamed Abdulla Ahmed, Seyedeh-Somayyeh Shafiei-Masouleh, Riyadh Mannaa Mohsin, Ziyad Khalf Salih
Summary: This study aimed to enhance the yield and quality of Solidago through foliar application of Fe2O3 nanoparticles. The results showed that spraying 1 mg L-1 of nanoparticles 5 times significantly improved the growth and medicinal qualities of Solidago. Therefore, foliar application of ferric oxide nanoparticles is a safe and cost-effective method.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Marton Baglyas, Peter G. Ott, Ildiko Schwarczinger, Judit Kolozsvarine Nagy, Andras Darcsi, Jozsef Bakonyi, Agnes M. Moricz
Summary: Solidago rugosa, a native goldenrod species in North America, has become a sporadic alien plant in Europe. Two antimicrobial components, (-)-hardwickiic acid and (-)-abietic acid, were isolated from the root and leaf ethanol extracts of the plant. Both compounds demonstrated antibacterial activity, especially against Gram-positive bacterial strains. Compound 1 also showed significant antifungal activity against Bipolaris sorokiniana.
Article
Plant Sciences
Dominik Popowski, Monika E. Czerwinska, Aleksandra Kruk, Karolina A. Pawlowska, Jurgen Zentek, Matthias F. Melzig, Jakub P. Piwowarski, Sebastian Granica
Summary: Goldenrod is a traditional medicinal plant used in Europe and North America for urinary tract and skin disorders. Research shows that compounds in goldenrod infusion can be metabolized by human and swine gut microbiota into smaller phenylpropionic acid derivatives with better permeability through the gut epithelial barrier.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Agnes M. Moricz, Daniel Kruezselyi, Peter G. Ott, Zsofia Garadi, Szabolcs Beni, Gertrud E. Morlock, Jozsef Bakonyi
Summary: The study screened bioactive compounds in Giant goldenrod root extract using HPTLC and identified clerodane diterpenes as the active compounds through NMR spectroscopy. All isolates demonstrated inhibitory activity against at least one of the tested microorganisms.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Biochemical Research Methods
Marton Baglyas, Peter G. Ott, Zsofia Garadi, Vesna Glavnik, Szabolcs Beni, Irena Vovk, Agnes M. Moricz
Summary: This study introduced a high-performance thin-layer chromatography-direct bioautography method to discover four new cis-clerodane diterpenes from giant goldenrod leaves, showing moderate antibacterial activity against certain bacterial strains.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Plant Sciences
A. M. Walczyk, E. I. Hersch-Green
Summary: Plants require water and nutrients for survival, and genome size variation is suspected to influence plant water and nutrient requirements. This study investigates how genome size variation affects plant morphological and physiological traits under different water and nutrient availabilities. The results show that resource availabilities and cytotype identity independently influence plant responses, and nutrient and water availability could influence competitive outcomes. The study suggests that genome size may play a role in cytogeographic range patterning and population establishment likelihood.
Article
Biology
Artur Pliszko, Justyna Pazucha, Artur Gorecki
Summary: Solidago xniederederi, a naturalized alien taxon in Europe, shows high ability of synflorescence regeneration. Cutting off the synflorescences during flowering is not an effective method to control this hybrid species.
Article
Agriculture, Multidisciplinary
Hang Sun, Mohammad Fawad Ansari, Bo Fang, Cheng-He Zhou
Summary: Berberine-hybridized benzimidazoles, such as the 2,4-dichlorobenzyl derivative 7d, showed potent antibacterial efficacy against Staphylococcus aureus, with the ability to eradicate bacterial biofilm and low toxicity towards mammalian cells. Combination with norfloxacin enhanced the antibacterial efficacy, while development of bacterial resistance was not observed. Mechanism studies indicated that the active molecule 7d damaged membrane integrity, stimulated ROS generation, and bound with DNA and S. aureus sortase A, exerting powerful antibacterial ability in treating S. aureus in the livestock industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chunling Wei, Peiwu Cui, Xiangqian Liu
Summary: Antibacterial resistance is a serious global health problem, and scientists are focusing on developing new antibacterial drugs from natural products. This study investigated the antibacterial activity and mechanism of madecassic acid (MA), a compound isolated from Chinese medicine. It was found that MA had inhibitory effects on eight pathogenic bacteria, with a minimum inhibitory concentration of 31.25μg/mL for Staphylococcus aureus.
Article
Infectious Diseases
Jordana Damasceno Gitirana de Santana, Oscar Alejandro Santos-Mayorga, Jonatas Rodrigues Florencio, Mirella Chrispim Cerqueira de Oliveira, Luisa Maria Silveira de Almeida, Julianna Oliveira de Lucas Xavier, Danielle Cristina Zimmermann-Franco, Gilson Costa Macedo, Adriana Lucia Pires Ferreira, Orlando Vieira de Sousa, Ademar Alves da Silva Filho, Maria Silvana Alves
Summary: This study investigated the chemical constituents and antibacterial activity of the medicinal plant Vernonia polyanthes. The results showed that the V. polyanthes leaf rinse extract (Vp-LRE) contained glaucolide A, which exhibited significant antibacterial activity against MRSA strains. Additionally, other compounds in Vp-LRE were found to interact with beta-lactamase. These findings suggest that V. polyanthes could serve as a potential natural source of phytochemicals with antibiotic properties.
Article
Biochemistry & Molecular Biology
Xiaoyan Hou, Jianlong Li, Huaqiao Tang, Qingye Li, Guanghui Shen, Shanshan Li, Anjun Chen, Zixin Peng, Yu Zhang, Chaowei Li, Zhiqing Zhang
Summary: Our study investigated the physicochemical properties of antibacterial peptide NP-6 and elucidated its antimicrobial mechanisms against Staphylococcus aureus. The results showed that NP-6 can disrupt the bacterial cell membrane and inhibit the activity of intracellular enzymes. These findings suggest that NP-6 has the potential to be a promising candidate for combating Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thibaut Barbier, Alexia Barbry, Jeremy Magand, Cedric Badiou, Floriane Davy, Anne Baudouin, Yves Queneau, Oana Dumitrescu, Gerard Lina, Laurent Soulere
Summary: In this study, new series of compounds were synthesized by combining the benzo[b]thiophene nucleus and the acylhydrazone functional group for screening against Staphylococcus aureus. Among the compounds tested, (E)-6-chloro-N'-(pyridin-2-ylmethylene)benzo[b]thiophene-2-carbohydrazide (II.b) showed promising antimicrobial activity with a minimal inhibitory concentration of 4 μg/mL against S. aureus strains, including clinically isolated strains resistant to methicillin and daptomycin.
Article
Food Science & Technology
Yawei Ning, Linlin Hou, Mengge Ma, Mingrui Li, Zhongqing Zhao, Dongchun Zhang, Zhixin Wang, Yingmin Jia
Summary: Sucrose laurate (SL) is a dual-functional additive with emulsifying and antibacterial activities. The synergistic antibacterial mechanism of SL and nisin were studied against Staphylococcus aureus. This research provides insights into broadening the application of SL in food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Yangli Wan, Xiaowen Wang, Pengfei Zhang, Meng Zhang, Mingying Kou, Chao Shi, Xiaoli Peng, Xin Wang
Summary: Shikonin shows excellent antibacterial activity against foodborne Staphylococcus aureus by inhibiting growth, reducing ATP concentrations, hyperpolarizing cell membrane, destroying membrane integrity, and inhibiting biofilm formation. It also significantly decreases the expression of virulence genes and shows potential as a natural food additive.
Article
Infectious Diseases
Sakari Nikinmaa, Anna Podonyi, Peter Raivio, Jukka Meurman, Timo Sorsa, Juha Rantala, Esko Kankuri, Tuomas Tauriainen, Tommi Paetilae
Summary: Dual-light aPDT shows improved bactericidal effect on Staphylococcus aureus biofilm compared to aPDT or aBL, providing a sustained effect. Increasing the relative ratio of aBL enhances the antibacterial effect, especially with repeated applications.
Article
Chemistry, Medicinal
Jessica Solimine, Eliane Garo, Jonas Wedler, Krasimir Rusanov, Orlando Fertig, Matthias Hamburger, Ivan Atanassov, Veronika Butterweck
Article
Plant Sciences
Russell B. Williams, Steven M. Martin, Julie A. Lawrence, Vanessa L. Norman, Mark O'Neil-Johnson, Gary R. Eldridge, Courtney M. Starks
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Chemistry, Organic
Zhongping Huang, Russell B. Williams, Mark O'Neil-Johnson, Gary R. Eldridge, John E. Mangette, Courtney M. Starks
JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Plant Sciences
Sheela Verjee, Eliane Garo, Sarah Pelaez, Orlando Fertig, Matthias Hamburger, Veronika Butterweck
Article
Chemistry, Medicinal
Zhongping Huang, Russell B. Williams, Steven M. Martin, Julie A. Lawrence, Vanessa L. Norman, Mark O'Neil-Johnson, Jim Harding, John E. Mangette, Shuang Liu, Peter R. Guzzo, Courtney M. Starks, Gary R. Eldridge
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Sandra Irmisch, Seohyun Jo, Christopher R. Roach, Sharon Jancsik, Macaire Man Saint Yuen, Lufiani L. Madilao, Mark O'Neil-Johnson, Russel Williams, Stephen G. Withers, Joerg Bohlmann
Article
Biochemistry & Molecular Biology
Julie A. Lawrence, Zhongping Huang, Sivaprakash Rathinavelu, Jin-Feng Hu, Eliane Garo, Michael Ellis, Vanessa L. Norman, Ronald Buckle, Russell B. Williams, Courtney M. Starks, Gary R. Eldridge
BIOORGANIC & MEDICINAL CHEMISTRY
(2020)
Article
Agriculture, Dairy & Animal Science
Michael Walkenhorst, Florian Leiber, Ariane Maeschli, Alexandra N. Kapp, Anet Spengler-Neff, Maria Teresa Faleschini, Eliane Garo, Matthias Hamburger, Olivier Potterat, Philipp Mayer, Sandra Graf-Schiller, Anna Bieber
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2020)
Article
Plant Sciences
Tanja Hell, Adriano Rutz, Lara Durr, Maciej Dobrzynski, Jakob K. Reinhardt, Timo Lehner, Morris Keller, Anika John, Mahabir Gupta, Oliv Pert, Matthias Hamburger, Jean-Luc Wolfender, Eliane Garo
Summary: The combination of HPLC-based activity profiling and advanced UHPLC-HRMS/MS metabolite profiling allows for the identification of highly active compounds in crude extracts, which can be beneficial to the drug discovery process. This strategy was successfully applied to a subset of extract library screening, leading to the identification and isolation of potent natural products inhibiting oncogenic signaling in melanoma.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Lara Duerr, Tanja Hell, Maciej Dobrzynski, Alberto Mattei, Anika John, Nathanja Augsburger, Gloria Bradanini, Jakob K. Reinhardt, Florian Rossberg, Milos Drobnjakovic, Mahabir P. Gupta, Matthias Hamburger, Olivier Pertz, Eliane Garo
Summary: This study identified natural products that can inhibit oncogenic signaling in melanoma through a combination of techniques.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Nutrition & Dietetics
Karley K. Mahalak, Jamshed Bobokalonov, Jenni Firrman, Russell Williams, Bradley Evans, Brian Fanelli, Jason W. Soares, Masuko Kobori, LinShu Liu
Summary: In this study, we found that regular consumption of capsaicin can change the structure of the gut microbial community and increase the abundance of certain short-chain fatty acids, particularly butanoic acid. These changes may be responsible for the health benefits associated with capsaicin consumption.
Article
Medicine, Research & Experimental
Tanja Hell, Maciej Dobrzynski, Fabian Groeflin, Jakob K. Reinhardt, Lara Duerr, Olivier Pertz, Matthias Hamburger, Eliane Garo
Summary: The PI3K/AKT and MAPK/ERK pathways are frequently mutated in metastatic melanoma. In this study, a plant extract from Ericameria nauseosa was found to inhibit the oncogenic activity of AKT in human melanoma cells. Further analysis led to the identification of several active compounds, including flavones, which were more potent than flavanones. Two new natural products, diterpenes, were also discovered in this extract.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Lara Durr, Jakob K. Reinhardt, Maciej Dobrzynski, Tanja Hell, Martin Smiesko, Olivier Pertz, Matthias Hamburger, Eliane Garo
Summary: A screening of over 2500 plant extracts in melanoma cells revealed that the ethyl acetate extract from Artemisia argyi displayed significant inhibition of the PI3K/AKT pathway. Through activity profiling, 21 active compounds were isolated, including one novel dimerosequiterpenoid, one new disesquiterpenoid, three new guaianolides, 12 known sesquiterpenoids, and four known flavonoids.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Analytical
Alen Bozicevic, Maciej Dobrzynski, Hans De Bie, Frank Gafner, Eliane Garo, Matthias Hamburger
ANALYTICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.
