Article
Biochemistry & Molecular Biology
Haoran Sun, Jiajia Wang, Bo Zhen, Xue Wang, Xinyue Suo, Mingbao Lin, Jiandong Jiang, Tengfei Ji
Summary: Seven new polycyclic polyprenylated acylphloroglucinol derivatives, hypseudohenrins A-G, were isolated from Hypericum pseudohenryi, along with six known analogs. Compounds B and G showed good anti-inflammatory activity, while uraloidin A exhibited high NO inhibition ratio. However, none of the compounds demonstrated desirable activity in anti-cancer and neural-protective screenings.
Article
Biochemistry & Molecular Biology
Ji Yeong Yang, Jong-Bae Kim, Pyeongjae Lee, Sa-Hyun Kim
Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Santi Tip-pyang, Jirapast Sichaem
Summary: Two new chromanone acid derivatives, calophinophyllins A and B, along with a known compound, were isolated from Calophyllum inophyllum. Despite evaluation, none of the isolated compounds showed measurable activity against alpha-glucosidase.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Epigenetics plays a role in regulating gene expression, cell differentiation, and response to environmental stimuli. Helicobacter pylori (Hp) uses DNA methylation to silence genes in human gastric mucosa, which is a primary cause of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Peter Malfertheiner, M. Constanza Camargo, Emad El-Omar, Jyh-Ming Liou, Richard Peek, Christian Schulz, Stella I. Smith, Sebastian Suerbaum
Summary: Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Chemistry, Medicinal
Zhong-Bo Zhou, Peng-Yun Mou, You-Yi Huang, Hong Zeng, Zu-Liang Huang, Xian Wei
Summary: Eighteen polycyclic polyprenylated acylphloroglucinols were isolated from Hypericum scabrum Linn., including six new compounds. These compounds exhibited moderate cytotoxic activities and weak inhibitory activities.
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Peng-Ju Guo, Tong Chen, Liu Zheng, Shou Peng, Kai-Qing Lv, Wen-Qiong Wang, Li-Jiang Xuan
Summary: Phytochemical investigation of Hypericum japonicum led to the discovery of two new xanthones and several known compounds. The structures and properties were determined using various analytical techniques. The lipid-lowering activities of the isolated compounds were evaluated, showing significant effects on reducing lipid levels.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Immunology
Li Tang, Bo Tang, Yuanyuan Lei, Min Yang, Sumin Wang, Shiping Hu, Zhuo Xie, Yaojiang Liu, Israel Vlodavsky, Shiming Yang
Summary: Chronic gastritis caused by H. pylori infection is associated with up-regulation of heparanase, which facilitates the colonization of H. pylori in the gastric mucosa and exacerbates gastritis. Heparanase sustains a vicious cycle of inflammation and tumor progression by activating macrophages and promoting cytokine release, potentially increasing the risk of gastric cancer. Inhibition of heparanase may be a potential therapeutic strategy for reducing the risk of gastritis and gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Editorial Material
Microbiology
Daniel Falush
Summary: The genome of Helicobacter pylori undergoes extensive mixing through homologous recombination, resulting in significant free recombination within populations. A recent study reveals that the UvrC gene in H. pylori has evolved an additional function, allowing very short DNA tracts to be imported into the genome during natural transformation.
Review
Medicine, General & Internal
Dmitry S. Bordin, Irina N. Voynovan, Dmitrii N. Andreev, Igor Maev
Summary: This article reviews the various methods available for detecting Helicobacter pylori, including both invasive and non-invasive diagnostic tests, highlights the advancements and new developments in endoscopic examination techniques, and discusses the advantages and limitations of different diagnostic methods and their applications.
Article
Chemistry, Applied
Xiya Chen, Zhiying Liu, Bi Zhong, Mengjie Zhu, Han Yao, Xiaojie Chen, Yongchao Lu, Shuyun Wang, Yaping Guo
Summary: Eleven 4-phenylcoumarins, including three new compounds, were isolated from the flowering buds of Mesua ferrea. Compound 9 exhibited moderate cytotoxicity against multiple cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Review
Infectious Diseases
Julie Nguyen, Kallirroi Kotilea, Patrick Bontems, Veronique Yvette Miendje Deyi
Summary: In the context of epidemiology, the manifestation of Helicobacter pylori (H. pylori) infection varies between children and adults. The prevalence of H. pylori infection is decreasing globally, including in many developing countries. However, pediatric H. pylori infection and its consequences remain a concern in some areas. Most infected children do not show symptoms, and there is no evidence supporting the link between H. pylori and functional disorders like recurrent abdominal pain. The pathophysiology of H. pylori infection depends on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. Various gastritis phenotypes can develop, potentially leading to different gastroduodenal pathologies. The diagnosis of H. pylori infection in children requires upper gastrointestinal endoscopy with mucosal biopsy samples for histology and culture, or at least Polymerase Chain Reaction (PCR). Eradication treatment should be given when necessary and compliance is expected, with treatment choice based on antimicrobial susceptibility. Vigilant surveillance of resistance patterns and strategic antibiotic management are crucial for combating multidrug resistance.
Article
Chemistry, Applied
Chakapong Intaraudom, Nantiya Bunbamrung, Aibrohim Dramae, Nattawut Boonyuen, Wilunda Choowong, Pranee Rachtawee, Pattama Pittayakhajonwut
Summary: Two enantiomeric compounds, along with six known compounds, were isolated from the marine-associated fungus Taeniolella sp. BCC31839. Despite their chemical structures and absolute configurations being determined, they were found to be inactive against multidrug-resistant malaria parasite and bacteria.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Medicinal
Kazumi Sagayama, Naonobu Tanaka, Takatoshi Fukumoto, Yoshiki Kashiwada
JOURNAL OF NATURAL MEDICINES
(2019)
Article
Chemistry, Medicinal
Naonobu Tanaka, Kanji Niwa, Yuki Yano, Yoshiki Kashiwada
JOURNAL OF NATURAL MEDICINES
(2020)
Article
Plant Sciences
Kanji Niwa, Naonobu Tanaka, Yutaka Tatano, Hideki Yagi, Yoshiki Kashiwada
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Biochemistry & Molecular Biology
Kanji Niwa, Ren Yi, Naonobu Tanaka, Shindai Kitaguchi, Daisuke Tsuji, Sang-Yong Kim, Ariuntuya Tsogtbaatar, Perleidulam Bunddulam, Kazuyoshi Kawazoe, Mareshige Kojoma, Davaadagva Darndinjav, Kohji Itoh, Yoshiki Kashiwada
Article
Chemistry, Medicinal
Sanghoon Lee, Naonobu Tanaka, Sakura Takahashi, Daisuke Tsuji, Sang-Yong Kim, Mareshige Kojoma, Kohji Itoh, Jun'ichi Kobayashi, Yoshiki Kashiwada
Article
Chemistry, Organic
Naonobu Tanaka, Kanji Niwa, Seita Kajihara, Daisuke Tsuji, Kohji Itoh, Nilufar Z. Mamadalieva, Yoshiki Kashiwada
Review
Chemistry, Medicinal
Naonobu Tanaka, Yoshiki Kashiwada
Summary: Plants of the genus Hypericum are a rich source of natural products with diverse chemical structures and intriguing biological activities. Over 100 new characteristic metabolites have been isolated from 11 Hypericum plants and one Triadenum plant collected in Japan, China, and Uzbekistan, or cultivated in Japan, including prenylated acylphloroglucinols, meroterpenes, ketides, dibenzo-1,4-dioxane derivatives, and xanthones. These compounds hold promise as potential lead compounds for therapeutic agents.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Chemistry, Organic
Kohta Yamasaki, Akiho Yamauchi, Tsubasa Inokuma, Yasunori Miyakawa, Yinli Wang, Raphael Oriez, Yousuke Yamaoka, Kiyosei Takasu, Naonobu Tanaka, Yoshiki Kashiwada, Ken-ichi Yamada
Summary: The study confirmed an enantioselective intramolecular migrative cyclization reaction, where the use of chiral nucleophiles led to enantiomerically enriched products.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Kanji Niwa, Naonobu Tanaka, Yusei Shimomoto, Daisuke Tsuji, Sang-Yong Kim, Mareshige Kojoma, Kohji Itoh, Chin-Ho Chen, Kuo-Hsiung Lee, Yoshiki Kashiwada
Summary: Six dibenzo-1,4-dioxane derivatives were isolated from the roots of a Hypericaceous plant, with 2 and 4-6 being new compounds. Chiral HPLC analyses confirmed the partial racemic natures of 1-3, while 5 was identified as a racemate. The absolute configurations of 1-4 were deduced based on ECD calculations. Additionally, compound 7 exhibited anti-HIV activity and compound 8 showed inhibitory effects on IL-1 beta production from LPS-stimulated microglial cells.
JOURNAL OF NATURAL MEDICINES
(2021)
Review
Chemistry, Medicinal
Naonobu Tanaka, Yoshiki Kashiwada
Summary: Traditional herbal medicines are valuable resources of drug seeds, and ethnobotanical and ethnopharmacological surveys can provide useful information for searching new bioactive molecules. Studies have been conducted in regions such as Yunnan Province, Guangxi Zhuang Autonomous Region, Uzbekistan, and Bangladesh to investigate traditional herbal medicines and search for active substances through bioassay-guided fractionation and isolation, resulting in the isolation of more than 150 new molecules with various biological activities.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Chemistry, Multidisciplinary
Daiki Sato, Masaya Denda, Honoka Tsunematsu, Naonobu Tanaka, Isamu Konishi, Chiaki Komiya, Akira Shigenaga, Akira Otaka
Summary: Intramolecular S-acylation of a thiol-installed threonine with a thioester unit, followed by S-O acyl transfer and subsequent desulphurisation allows the synthesis of lactone peptides. A protocol has been developed enabling the cyclisation of a linear peptide, a reaction which has not been achieved by conventional methods.
CHEMICAL COMMUNICATIONS
(2022)
Article
Plant Sciences
Naonobu Tanaka, Yuki Yoshino, Fusako Nakano, Shin-Ichiro Kurimoto, Kazuyoshi Kawazoe, Daisuke Tsuji, Kohji Itoh, Shun-Lin Li, Han-Dong Sun, Yoshihisa Takaishi, Yoshiki Kashiwada
Summary: In this study, two new guaianolide sesquiterpenes were isolated from Saussurea laniceps, a traditional herbal medicine. The structures of these compounds were determined through spectroscopic analysis and computational methods. Furthermore, these compounds exhibited inhibitory activity against IL-1 beta production from LPS-stimulated microglial cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Medicinal
Yuki Yoshino, Naonobu Tanaka, Daisuke Tsuji, Kohji Itoh, Yoshiki Kashiwada
Summary: Three new farnesylated coumarins and one farnesylated chromone were isolated from the roots of Ferula communis. Their structures and relative configurations were determined by spectroscopic analysis and NMR data calculation. These compounds showed inhibitory activities on IL-1 beta production from LPS-stimulated microglial cells.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Aurpita Shaha, Rezwanul Islam, Naonobu Tanaka, Yoshiki Kashiwada, Hiroyuki Fukui, Noriaki Takeda, Yoshiaki Kitamura, Hiroyuki Mizuguchi
Summary: The active compound betuletol found in Brazilian green propolis can suppress the expression of the allergic gene IL-33 and reduce eosinophilia. It also inhibits the phosphorylation of ERK, indicating its potential in treating IL-33 mediated eosinophilic chronic inflammation.
Article
Plant Sciences
Naonobu Tanaka, Sakura Takahashi, Yuki Yoshino, Megumi Nakatani, Fakhruddin Ali Ahmed, Gazi Mosharof Hossain, Chin-Ho Chen, Kuo-Hsiung Lee, Yoshiki Kashiwada
Summary: Four new diterpene esters were isolated from the fruits of Shirakiopsis indica and their structures were determined. Among them, shirakindican A and B possess unique structures. In addition, the antiviral activity against HIV was evaluated, and sapintoxins A and D showed significant activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.
