Journal
PHYTOCHEMISTRY
Volume 69, Issue 5, Pages 1173-1178Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2007.12.004
Keywords
Syagrus romanzoffiana; arecaccae; alpha-glucosidase inhibitor; stilbenoids; 13-hydroxykompasinol A; scirpusin C; type 2 diabetes
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Bioassay-guided fractionation against alpha-glucosidase resulted in isolation and characterization of eight active compounds from the EtOH extract of the seeds of Syagrus romanzoffiana. Of these, seven are stilbenoids, and two of them, 13-hydroxykompasinol A (1) and scirpusin C (4), possess potent inhibitory activity against alpha-glucosidase type IV from Bacillus stearothermophilus with the IC(50) value of 6.5 and 4.9 mu M, respectively. The in vivo assay on normal Wistar rats using oral sucrose challenge also demonstrated that kompasinol A (2) and 3,3',4,5,5'-pentahydroxy-trans-stilbene (5) possess significant effect in reducing the postprandial blood glucose level (10.2% and 12.1% at 10 mg/kg, respectively). These results suggest that stilbenoids might be explored for their therapeutic potential as hypoglycemic agents. (c) 2007 Elsevier Ltd. All rights reserved.
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