Journal
PHYTOCHEMISTRY
Volume 69, Issue 6, Pages 1348-1358Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.01.017
Keywords
Cryptomeria japonica; Taxodiaceae; hepatoprotection; cycloxygenase-2; nitric oxide; inducible nitric oxide synthase; heme oxygenase-1; terpenoids
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Cryptomeria japonica is an important plantation conifer tree in Asia. This study aimed to characterize the anti-inflammatory and hepatoprotective activities of the phytocompounds from C japonica wood on LPS- or TPA-induced activation of proinflammatory mediators and CCl4-induced acute liver injury in mice. A CJH7-3 fraction was purified from C japonica extracts following bioactivity-guided fractionation, and it exhibited significant activities on inhibition of NO production and iNOS expression as well as up-regulating HO-1 expression in LPS-stimulated macrophages. CJH7-2 also potently inhibits COX-2 enzymatic activity (IC50 = 5 mu g/mL) and TPA-induced COX-2 protein expression in mouse skin (1 mg/200 mu L/site). CJH7-2 (10 mg/kg BW) can prevent CC14-induced liver injury and aminotransferases activities in mice. Chemical fingerprinting analysis showed that terpenes are the major bioactive compounds in the CJH7-2 fraction. This is the first stud), to demonstrate that chemical constituents from the wood extract of C japonica possess anti-inflammatory activities in vitro and in vivo that may play a role in hepatoprotection. (C) 2008 Elsevier Ltd. All rights reserved.
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