Article
Endocrinology & Metabolism
Tingting Lin, Shuyu Zhang, Yuchuan Zhou, Ligang Wu, Xinmei Liu, Hefeng Huang
Summary: The study found that physical exercise can effectively improve the negative impact of obesity on male fertility. Small noncoding RNAs, especially microRNAs in germ cells, may play a critical role in the effects of obesity and physical exercise on spermatozoa.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Transplantation
Daniel S. March, Ka-Bik Lai, Tracy Neal, Matthew P. M. Graham-Brown, Patrick J. Highton, Darren R. Churchward, Hannah M. L. Young, Maurice Dungey, David J. Stensel, Alice C. Smith, Nicolette C. Bishop, Cheuk Chun Szeto, James O. Burton
Summary: This study aimed to investigate the effect of intradialytic cycling (IDC) on circulating endotoxin and cytokines. The results showed no significant change in circulating endotoxin and cytokines following a 6-month IDC program. However, higher levels of physical activity were associated with lower levels of inflammation.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cell Biology
Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen
Summary: This study found that specific miRs were associated with coronary plaque components in patients with coronary artery disease. After aerobic exercise intervention, changes in miR levels were associated with a regression of coronary plaque burden. These findings may contribute to the development of biomarkers for coronary artery disease and coronary plaque composition.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Sport Sciences
Eero A. Haapala, Juuso Vaisto, Johanna K. Ihalainen, Claudia Tomaselli Gonzalez, Marja H. Leppanen, Aapo Veijalainen, Taisa Sallinen, Aino-Maija Eloranta, Ulf Ekelund, Ursula Schwab, Soren Brage, Mustafa Atalay, Timo A. Lakka
Summary: The study showed that physical activity is inversely associated with inflammatory biomarkers in children, while sedentary time is directly associated with them. Additionally, physical activity has a stronger inverse association with inflammatory biomarkers in children with a higher body fat percentage.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Byunghun So, Li Li Ji, Saba Imdad, Chounghun Kang
Summary: This study aimed to investigate the effect of voluntary wheel running (VWR) on the metabolic changes in the livers of high-fat diet (HFD)-induced NAFLD mice. LC-MS/MS was used to determine whether the tested intervention affected the protein expression profiles of the mouse livers. The results showed that VWR counteracted the adverse effects of HFD on the livers of the mice and affected the expression of proteins involved in ketogenesis, lipid metabolism, and the metabolism of drugs and xenobiotics.
Article
Multidisciplinary Sciences
Paloma Ferrero-Hernandez, Claudio Farias-Valenzuela, Emilio Jofre-Saldia, Adilson Marques, Irina Kovalskys, Georgina Gomez, Attilio Rigotti, Lilia Yadira Cortes, Martha Yepez Garcia, Rossina G. Pareja, Marianella Herrera-Cuenca, Mauro Fisberg, Danilo R. Silva, Kabir P. Sadarangani, Gerson Ferrari
Summary: This study aims to establish cut-off points for the number of minutes of physical activity intensity and the number of daily steps that identify overweight/obesity in adolescents, adults, and older adults. The results can be used to develop specific recommendations for the prevention of overweight/obesity.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Emmanuelle Rochette, Oussama Saidi, Etienne Merlin, Pascale Duche
Summary: Juvenile idiopathic arthritis (JIA) is a common rheumatic disease in young people. The physical activity of children and adolescents with JIA is lower than their healthy counterparts, which may be due to joint pain and decreased physical capacities. Increased physical activity and exercise have shown potential benefits in improving various health outcomes in JIA. However, more research is needed to establish evidence-based guidelines for physical activity and exercise prescription in this population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Jean-Michel Oppert, Alice Bellicha, Cecile Ciangura
Summary: Physical activity and exercise have various benefits for individuals with obesity, aiding in weight loss and reduction of body fat. Different types of training have slightly different effects on weight loss but all improve physical fitness and reduce cardiovascular risk. Tailored physical activity counseling and exercise prescriptions are crucial in achieving specific treatment goals for individual patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Physiology
Joseph A. Taylor, Paul L. Greenhaff, David B. Bartlett, Thomas A. Jackson, Niharika A. Duggal, Janet M. Lord
Summary: Frailty is a state characterized by increased vulnerability and decreased ability to recover from stress compared to non-frailty. It is important to understand the clinical and physiological features of frailty, as well as the factors driving it, due to the increasing life expectancy and prevalence of physical frailty.
PHYSIOLOGICAL REVIEWS
(2023)
Review
Physiology
Joseph A. Taylor, Paul L. Greenhaff, David B. Bartlett, Thomas A. Jackson, Niharika A. Duggal, Janet M. Lord
Summary: Frailty refers to a state of enhanced vulnerability and impaired recovery compared to a nonfrail state, which is considered a loss of resilience. It is important to understand the clinical and physiological features of frailty and its driving factors due to the increasing life expectancy and prevalence of physical frailty. This article describes the clinical definitions of age-related frailty and their limitations, explores the physiological components of frailty, and emphasizes the importance of longitudinal and interventional clinical studies to identify mechanistic drivers and target interventions to reduce frailty progression.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Tahmina Akter, Zebunnesa Zeba, Ismail Hosen, Firoj Al-Mamun, Mohammed A. Mamun
Summary: During the pandemic, some participants experienced an increase in overweight status, but following a proper diet plan can significantly decrease BMI status.
Article
Biochemistry & Molecular Biology
Manuela Cabiati, Letizia Guiducci, Emioli Randazzo, Valentina Casieri, Giovanni Federico, Silvia Del Ry
Summary: This study aimed to assess the circulating profile of miR-33a in normal-weight and obese adolescents, and correlate its expression levels with their metabolic parameters. The results showed that circulating miR-33a levels were significantly higher in obese adolescents and correlated with some metabolic parameters. The expression of exosomal miR-33a in plasma was lower and not correlated with metabolic parameters. Therefore, circulating miR-33a can provide important indications in the initial phase of metabolic dysfunction, stratifying obese adolescents at higher cardiometabolic risk.
Article
Medicine, General & Internal
Ioana Taranu, Mihaela Iancu, Cecilia Lazea, Camelia Alkhzouz, Nicoleta Racataianu, Cristina-Sorina Catana, Andreea-Manuela Mirea, Diana Miclea, Sorana D. Bolboaca, Cristina Drugan
Summary: Childhood obesity is associated with low-grade inflammation. This study examined the change in chitotriosidase (CHIT1) plasma activity in pediatric patients to understand its underlying pathogenesis. The study found that children with extreme obesity had higher CHIT1 plasma activity. The study also investigated the impact of CHIT1 gene variants on the association between CHIT1 activity and obesity level. The findings suggest that circulating CHIT1 may serve as an indicator of inflammation in children with obesity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Sport Sciences
Chelsea L. Kracht, Peter T. Katzmarzyk, Cathierine M. Champagne, Stephanie T. Broyles, Daniel S. Hsia, Robert L. Newton, Amanda E. Staiano
Summary: This study aimed to examine the effects of substituting sedentary time with sleep or physical activity on adiposity in a longitudinal sample of adolescents. The results showed that substituting sedentary time with vigorous-intensity physical activity was related to lower adiposity in later adolescence. Promoting a balance of sleep, sedentary time, and physical activity in all adolescents is encouraged for optimal development.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Cardiac & Cardiovascular Systems
Amedeo Tirandi, Fabrizio Montecucco, Luca Liberale
Summary: The amount of physical activity practiced by people has been decreasing in recent decades, leading to higher risks of atherosclerosis and related cardiovascular events. Regular physical activity has beneficial effects on metabolism and can help prevent cardiovascular diseases. Several studies have found lower levels of plasma lipids in individuals who engage in exercise, but the exact mechanisms by which physical activity modulates lipoproteins are still not fully understood.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Aaron L. Slusher, Michael Whitehurst, Arun Maharaj, Katelyn M. Dodge, Brandon G. Fico, J. Thomas Mock, Chun-Jung Huang
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2018)
Article
Medicine, Research & Experimental
Peter J. Ferrandi, Brandon G. Fico, Michael Whitehurst, Michael C. Zourdos, Fanchen Bao, Katelyn M. Dodge, Alexandra L. Rodriguez, Gabriel Pena, Chun-Jung Huang
Article
Biochemistry & Molecular Biology
Chun-Jung Huang, Alexandra L. Rodriguez, Nishant P. Visavadiya, Brandon G. Fico, Aaron L. Slusher, Peter J. Ferrandi, Michael Whitehurst
Summary: This study investigated the molecular activity of autophagy and apoptosis in peripheral blood mononuclear cells (PBMCs) after maximal aerobic exercise in obese and normal-weight individuals. The findings suggest that the regulation of autophagy and apoptotic pathways differs between obese and normal-weight individuals following maximal aerobic exercise.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Fereshteh Ahmadabadi, Marziyeh Saghebjoo, Chun-Jung Huang, Iman Saffari, Mahmoud Zardast
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Article
Nutrition & Dietetics
Justin M. Quiles, Alex Klemp, Chad Dolan, Arun Maharaj, Chun-Jung Huang, Andy Khamoui, Eric T. Trexler, Michael Whitehurst, Michael C. Zourdos
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Brisamar Estebanez, Alexandra L. Rodriguez, Nishant P. Visavadiya, Michael Whitehurst, Maria J. Cuevas, Javier Gonzalez-Gallego, Chun-Jung Huang
Review
Cell Biology
Brisamar Estebanez, David Jimenez-Pavon, Chun-Jung Huang, Maria J. Cuevas, Javier Gonzalez-Gallego
Summary: This review systematically investigates the effects of exercise on the release and cargo of exosomes, showing that exercise promotes exosome release without modifying their size and leads to an increase in specific exosome markers. Various exosome-carried microRNAs involved in regulating skeletal muscle tissue proliferation and differentiation are released in response to exercise. However, methodological factors such as exosome isolation and characterization, as well as timing of sample recovery post-exercise, can impact the analysis and interpretation of findings.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Brisamar Estebanez, Nishant P. Visavadiya, Jose A. de Paz, Michael Whitehurst, Maria J. Cuevas, Javier Gonzalez-Gallego, Chun-Jung Huang
Summary: Aging-associated inflammation is characterized by high levels of inflammatory mediators, while exosome-mediated cell-to-cell communication plays a role in cellular senescence and aging. Resistance training in elderly individuals may have an anti-inflammatory effect evidenced by a decrease in exosome CD63 protein expression, despite no changes in plasma miR-146a-5p and cfDNA levels.
Article
Physiology
F. Ahmadabadi, M. Saghebjoo, M. Hedayati, R. Hoshyar, C. -j. Huang
Summary: The study showed that both high-intensity interval training (HIIT) and saffron aqueous extract (SAE) can significantly reduce tumor volume in breast cancer-bearing mice, and also modulate pro- and anti-apoptotic protein expression.
PHYSIOLOGY INTERNATIONAL
(2021)
Correction
Physiology
Aaron L. Slusher, Brandon G. Fico, Katelyn M. Dodge, Ryan S. Garten, Peter J. Ferrandi, Alexandra A. Rodriguez, Gabriel Pena, Chun-Jung Huang
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Fereshteh Ahmadabadi, Hossein Nakhaei, Mehdi Mogharnasi, Chun-Jung Huang
Summary: The study found that both aerobic continuous training and aerobic interval training can increase irisin levels in LT and VAT of rats, with aerobic interval training showing a more significant improvement in LT levels. Compared to the control group, both training groups had lower levels of chemerin in LT and VAT, but only the aerobic interval training group showed a reduction in serum asprosin levels and improvements in cardiometabolic markers such as HOMA-IR and lipid profile.
PHYSIOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Brisamar Estebanez, Nishant P. Visavadiya, Jose E. Vargas, Marta Rivera-Viloria, Andy Khamoui, Jose A. de Paz, Chun-Jung Huang
Summary: Resistance training can improve endoplasmic reticulum stress response in elderly individuals, according to this study.
Article
Biology
Brandon G. Fico, Ryan S. Garten, Michael C. Zourdos, Michael Whitehurst, Peter J. Ferrandi, Katelyn M. Dodge, Gabriel S. Pena, Alexandra A. Rodriguez, Chun-Jung Huang
Summary: This study compared the acute effects of high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CME) on vascular health indicators in individuals with obesity. The results showed that both exercise modalities led to improvements in vascular health, with HIIE being a time-effective strategy. Additionally, CME had a greater effect on improving endothelial function in obese participants.
Review
Biology
Brandon G. Fico, Arun Maharaj, Gabriel S. Pena, Chun-Jung Huang
Summary: Our aging population and the increasing prevalence of obesity have become a significant health issue as they contribute to the development of related diseases. This review explores the interaction and impact of obesity and aging on inflammatory, cardiovascular, and neurobiological processes. It emphasizes the role of exercise in mediating these effects in older adults.
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)