Article
Health Care Sciences & Services
Keren Nitzan, Roni Toledano, Shiran Shapira, Nadir Arber, Ravid Doron
Summary: The study found that CD24 knockout mice exhibited better cognitive performance and less anxiety-like behavior compared to wild-type mice, with no effect on depression-like behavior. This phenotype remained constant from childhood to adulthood.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychiatry
Chao Ciu-Gwok Guo, Tao He, Joanes Grandjean, Judith Homberg
Summary: In the study, it was discovered that 5-HTT KO rats processed visual information faster than WT rats during outcome generalization, while showing less ability to update changes in information during stimulus generalization. This suggests that KO 5-HTT modulates information processing when the environment changes.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Danielle M. Diniz, Francesca Calabrese, Paola Brivio, Marco A. Riva, Joanes Grandjean, Judith R. Homberg
Summary: BDNF plays a crucial role in neuroplasticity, vulnerability and resilience to stress-related disorders. Modulation of BDNF levels in the ventral hippocampus of SERT-/- rats led to positive behavioral outcomes, suggesting BDNF upregulation as a potential target for new therapeutic approaches in improving depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Noreen Samad, Farheen Hafeez, Imran Imran
Summary: This study demonstrates that selenium can effectively inhibit anxiety, depression, and memory impairment induced by D-galactose in mice, by reducing oxidative stress and inflammation, and increasing antioxidant enzyme activity. Additionally, selenium can also modulate neurotransmitter metabolism.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Rodrigo Castaneda, Armando Caceres, Diana Velasquez, Cesar Rodriguez, David Morales, Andrea Castillo
Summary: The study provides an overview of medicinal plants used by traditional healers and Mayan groups in Mesoamerica for CNS disorders, linking traditional use with pharmacological evidence. The research found 155 plants used for ethnopsychiatric conditions, with only 49 native species having reported pharmacological analyses. The study emphasizes the need for further research due to limited data on mechanism of action and lack of clinical studies.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Behavioral Sciences
Jonathan Acevedo, Jessica A. Siegel
Summary: This review summarizes the literature on the neurobiological and behavioral effects of adolescent ketamine exposure. The studies show that adolescent ketamine exposure may lead to neurotoxicity and apoptosis, and result in changes in locomotor activity, social behaviors, anxiety and depression-like behaviors, and memory.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Inci Turan, Hale Sayan Ozacmak, V. Haktan Ozacmak, Meryem Ergenc, Taner Bayraktaroglu
Summary: The study reveals that REM sleep deprivation impairs memory, increases anxiety and depression-like behaviors, while exenatide treatment can improve memory performance, restore CaMKII levels in the hippocampus, and reduce locomotor activity.
BRAIN RESEARCH BULLETIN
(2021)
Article
Psychology, Multidisciplinary
Fatima Al-Darmaki, Haleama Al Sabbah, Dalia Haroun
Summary: This study investigated bullying behaviors among college students at a national university in the UAE, as well as the psychological characteristics of those who have experienced bullying. The results showed that 26.3% of the students had either been exposed to or engaged in bullying behavior. Traditional bullying, such as face-to-face bullying, verbal, and physical, was the most common type reported, while cyberbullying was less prevalent. Females were more likely to experience bullying than males, and most of the aggressors were peers. The study also found significant differences in aggressive personality traits and symptoms of depression, anxiety, and PTSD between those who had experienced bullying and those who had not.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Gudrian R. L. de Almeida, Jozimar C. Szczepanik, Ingrid Selhorst, Mauricio P. Cunha, Alcir L. Dafre
Summary: This article presents the activity and role of methylglyoxal (MGO) in the central nervous system, as well as the relationship between MGO metabolism and pain, psychiatric, and cognitive-related diseases. Through reviewing preclinical studies and the impact on neurotransmitter systems, the article explores the modulating effects of MGO on behavior and diseases.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Xiyan Zhang, Tao Lv, Gerard Leavey, Na Zhu, Xin Li, Yan Li, Yanhua Chen
Summary: This study found that prosocial behavior has a protective effect against anxiety and depression in adolescents, but this effect is weaker in depressed adolescents. The comorbidity between anxiety and depression is common in adolescence, and interventions should take this into consideration.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Kinga Salaciak, Aleksandra Koszalka, Elzbieta Zmudzka, Karolina Pytka
Summary: CaMKII and CaMKIV are calcium/calmodulin-dependent kinases that play crucial roles in memory, plasticity, and various cellular functions. While they are primarily known for their involvement in memory processes, their effects on mood and neuropsychiatric diseases etiology are not well understood. This review aims to explore the structure and functions of these kinases and how they modulate behavior in animals to promote antidepressant-like, anxiolytic-like, and procognitive effects. The insights gained from this review can be beneficial in understanding the roles of these kinases in neurodegenerative and neuropsychiatric disorders and in future drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Robert J. McDonald, Nancy S. Hong, Jan S. Trow, Chelsea Kaupp, R. J. Balog, London Gokarn, Erin A. Falkenberg, Keiko J. McCreary, Nasrin Soltanpour, Carter Witbeck, Aimee McKenna, Gerlinde A. S. Metz
Summary: Prenatal experiences can have lasting effects on offspring physiology and behavior. Different forms of prenatal stress can impair learning and memory function in adults and increase the risk of anxiety and depression. This study focused on the effects of maternal stress induced by social isolation on cognitive functions in adult offspring, specifically spatial, stimulus-response, and emotional learning and memory.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Nandkishor Kotagale, Sandip Rahangdale, Anjali Borkar, Kundan Singh, Abhilasha Ikhar, Nikita Takale, Milind Umekar, Brijesh Taksande
Summary: Patients with diabetes mellitus have a higher risk of psychiatric and neurological disorders. Metformin, commonly used for type 2 diabetes management, has beneficial effects on neurogenesis and memory function. Research suggests a potential therapeutic strategy for diabetes-related conditions by combining agmatine and metformin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Steven J. Granger, Joren G. Adams, Sarah M. Kark, Mithra T. Sathishkumar, Ivy Y. Chen, Ruth M. Benca, Liv McMillan, John T. Janecek, Michael A. Yassa
Summary: This study found that anxiety symptoms are associated with impaired recognition memory for negative stimuli, particularly with somatic and cognitive anxiety factors. This suggests the impact of anxiety symptoms on memory function.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Hidde Heesakkers, Johannes G. van der Hoeven, Stijn Corsten, Inge Janssen, Esther Ewalds, Koen S. Simons, Brigitte Westerhof, Thijs C. D. Rettig, Cretien Jacobs, Susanne van Santen, Arjen J. C. Slooter, Margaretha C. E. van der Woude, Mark van den Boogaard, Marieke Zegers
Summary: The study found that physical, mental, and cognitive symptoms were frequently reported among COVID-19 patients one year after ICU treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Neurosciences
Gislaine Z. Reus, Morgana S. Abitante, Luana M. Manosso, Airam B. de Moura, Laura A. Borba, Maria Eduarda M. Botelho, Ana Caroline Darabas, Julia P. Demo, Joao Paulo Behenck, Camila O. Arent, Leandro Garbossa, Larissa Joaquim, Taiane A. Cardoso, Fabricia Petronilho, Joao Quevedo
Summary: This study investigated the effects of early stress, represented by maternal deprivation, on behavior and oxidative stress in rats. It was found that maternal deprivation can promote anxiety-like behavior and impair memory, while also increasing oxidative stress and altering antioxidant defenses. However, environmental enrichment was able to reverse these changes, although its effects were dependent on sex and developmental period.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychology, Clinical
Caroline Gurvich, Natalie Thomas, Abdul-Rahman Hudaib, Tamsyn E. Van Rheenen, Elizabeth H. X. Thomas, Eric J. Tan, Erica Neill, Sean P. Carruthers, Philip J. Sumner, Marco Romano-Silva, Kiymet Bozaoglu, Jayashri Kulkarni, Susan L. Rossell
Summary: This study explores the relationship between cognitive subgroups in bipolar-schizophrenia spectrum disorders and telomere length, and finds that shorter telomeres are associated with the severely impaired cognitive subgroup.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Luis E. B. Bettio, Priscila B. Rosa, Julia M. Rosa, Glorister A. Alte, Ana Lucia S. Rodrigues
Summary: This study reveals the antidepressant-like effect of Guanosine and the modulation of A(1)R and A(2A)R in its antidepressant action. Guanosine interacts with A(1)R and A(2A)R at the adenosine binding site.
PURINERGIC SIGNALLING
(2023)
Article
Clinical Neurology
German Josuet Lapo-Talledo, Jorge Andres Talledo-Delgado, Diego Portalanza, Ana Lucia S. Rodrigues, Aline Siteneski
Summary: Suicide rates and choice of suicide method have increased in Ecuador after natural disasters such as earthquakes and the COVID-19 confinement. Hanging accounted for the majority of suicide cases in the country. The province most severely affected by the 2016 earthquake saw an increased suicide rate.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Bruna R. Kouba, Ana Clara N. C. Torra, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Vitamin D-3 has shown antidepressant-like responses in mice, possibly through increasing BDNF levels and synaptic protein synthesis.
METABOLIC BRAIN DISEASE
(2023)
Letter
Biochemistry & Molecular Biology
Jonas J. de Paula, Fabio L. S. Duran, Geraldo Busatto, Debora M. Miranda, Marco A. Romano-Silva
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Ana P. Dalmagro, Glorister A. Alte, Ana Lucia B. Zeni, Carla I. Tasca, Ana Lucia S. Rodrigues
Summary: This study investigated the antidepressant-like and neuroprotective effects of guanosine and ketamine in mice and found that both substances showed protective effects against glutamate-induced damage. The combination of guanosine and ketamine exhibited enhanced antidepressant-like effects and increased glutamine synthetase activity and GLT-1 levels. The findings suggest that guanosine has potential as a treatment for depression and should be further studied.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Clinical Neurology
Taiane de Azevedo Cardoso, Ritele H. Silva, Jessica L. Fernandes, Camila O. Arent, Graziela Amboni, Laura A. Borba, Alex Paulo Z. Padilha, Maria Eduarda M. Botelho, Amanda L. Maciel, Tatiana Barichello, Rodrigo Morales, Silvia Jose B. Soares, Margarete D. Bagatini, Claudia Dallagnol, Marta Elisa Brighenti, Zuleide Maria Ignacio, Joao Quevedo, Luciane B. Ceretta, Gislaine Z. Reus
Summary: This study investigates the influence of COVID-19 infection on mental health and finds that individuals with COVID-19 show greater severity of depressive symptoms, higher levels of stress, and greater C-reactive protein (CRP) than those without COVID-19. There is a positive correlation between stress and severity of anxiety, depression, and insomnia in individuals with or without COVID-19. CRP levels are associated with the severity of depressive and anxiety symptoms, as well as stress levels, in individuals with COVID-19.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Debora de A. Simoes Moreira, Luis Eduardo Gauer, Guilherme Teixeira, Amanda Carolina Fonseca da Silva, Stefanie Cavalcanti, Joao Quevedo
Summary: This study compared the efficacy and tolerability of electroconvulsive therapy (ECT) and ketamine for different depression outcomes. The results showed no significant difference between ketamine and ECT in reducing the severity of depressive symptoms and response to therapy. However, there was a significant decrease in the risk of muscle pain with ketamine compared to ECT during treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Endocrinology & Metabolism
Bruna R. Kouba, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Alzheimer's disease is primarily caused by neuroinflammation, as evidenced by the co-localization of amyloid-beta plaques with activated glial cells and increased levels of inflammatory cytokines. Current pharmacological treatments are challenging, hence compounds with anti-inflammatory and antioxidant properties are being explored as potential therapies. Vitamin D, due to its neuroprotective effects and high prevalence of deficiency, has emerged as a promising candidate. This review highlights the antioxidant and anti-inflammatory properties of vitamin D, and its potential effects on the neuroinflammatory process in Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Taise Possamai-Della, Jose Henrique Cararo, Jorge M. Aguiar-Geraldo, Jefte Peper-Nascimento, Alexandra I. Zugno, Gabriel R. Fries, Joao Quevedo, Samira S. Valvassori
Summary: This study evaluated the effects of prenatal stress on behavior, HPA-axis, and epigenetic parameters in stressed dams and their offspring. It found that prenatal stress led to abnormal emotional behavior in female offspring, accompanied by hyperactivity of the HPA-axis and epigenetic adaptations in the activity of HDAC and DNMT, as well as acetylation in H3K9 and H3K14. In addition, prenatal stressed female offspring showed increased levels of ACTH compared to their male counterpart.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Camila N. C. Lima, Emese H. C. Kovacs, Salahudeen Mirza, Alexandra Del Favero-Campbell, Alexandre Paim Diaz, Joao Quevedo, Benney M. R. Argue, Jenny Gringer Richards, Aislinn Williams, John A. Wemmie, Vincent A. Magnotta, Jess G. Fiedorowicz, Jair C. Soares, Marie E. Gaine, Gabriel R. Fries
Summary: Bipolar disorder (BD) is associated with premature mortality and aging, including accelerated epigenetic aging. Suicide attempts (SA) are significantly higher in BD and are linked to decreased lifespan, biological aging, and poorer clinical outcomes. This study investigated the relationship between GrimAge, an epigenetic clock, and SA in BD individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
News Item
Biochemistry & Molecular Biology
Samira S. Valvassori, Joao Quevedo, Giselli Scaini
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Mehmet Enes Inam, Brisa S. Fernandes, Estela Salagre, Iria Grande, Eduard Vieta, Joao Quevedo, Zhongming Zhao
Summary: This study conducted a systematic review and meta-analysis to examine the KYN pathway metabolites in cerebrospinal fluid samples from patients with schizophrenia, bipolar disorder, and major depressive disorder. The results showed that KA levels were increased in schizophrenia, while the levels of TRP and KYN did not differ significantly. In bipolar disorder and major depressive disorder, there were no significant alterations in TRP and KA levels, although there may be a trend of increased KA levels and elevated QA levels in major depressive disorder. However, more studies are needed to confirm these findings.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)
