Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Aleksandra S. S. Stojiljkovic, Zeljko Cupic, Stevan Macesic, Ana Ivanovic-Sasic, Ljiljana Kolar-Anic
Summary: This study investigates the mechanisms underlying the effects of arginine vasopressin (AVP) on the Hypothalamic-Pituitary-Adrenal (HPA) axis and reveals the influence of the synergistic action between AVP and corticotrophin-releasing hormone (CRH) on the ultradian dynamics of the HPA axis. The extended nonlinear network reaction model incorporates AVP into the HPA axis model and explores the conditions under which the HPA system transitions between oscillatory and stable states. The results demonstrate the importance of the synergy reaction rate constant and highlight the superior stimulatory effect of CRH compared to AVP on ACTH secretion in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Letter
Biology
Hamed Malek, Mohammad Mehdi Ebadzadeh, Reza Safabakhsh, Alireza Razavi
Summary: The HPA axis generates ultradian rhythms through the pituitary-adrenal network, and can sustain even in the absence of CRH secretion. A two-dimensional delayed dynamical model based on ACTH and cortisol demonstrates the ability to capture low frequency rhythms.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Psychology, Multidisciplinary
Isabel Crespo-Sanmiguel, Mariola Zapater-Fajari, Matias M. Pulopulos, Vanesa Hidalgo, Alicia Salvador
Summary: The study found that early life stress (ELS) is associated with perceived stress, but not with HPA axis functioning. Loneliness mediates the relationship between ELS and perceived stress, but not between ELS and HPA axis functioning.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Endocrinology & Metabolism
Ali S. Alzahrani, Noha Mukhtar, Abeer Aljomaiah, Hadeel Aljamei, Abdulmohsen Bakhsh, Nada Alsudani, Tarek Elsayed, Nahlah Alrashidi, Roqayh Fadel, Eman Alqahtani, Hussein Raef, Muhammad Imran Butt, Othman Sulaiman
Summary: This study aimed to investigate the adrenocortical response to COVID-19 infection. The results revealed that patients with more severe disease had lower cortisol and ACTH levels, indicating a direct link between COVID-19 infection and impaired glucocorticoid response.
ENDOCRINE PRACTICE
(2021)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Irene Cimino, Hanna Kim, Y. C. Loraine Tung, Kent Pedersen, Debra Rimmington, John A. Tadross, Sara N. Kohnke, Ana Neves-Costa, Andre Barros, Stephanie Joaquim, Don Bennett, Audrey Melvin, Samuel M. Lockhart, Anthony J. Rostron, Jonathan Scott, Hui Liu, Keith Burling, Peter Barker, Menna R. Clatworthy, E-Chiang Lee, A. John Simpson, Giles S. H. Yeo, Luis F. Moita, Kendra K. Bence, Sebastian Beck Jorgensen, Anthony P. Coll, Danna M. Breen, Stephen O'Rahilly
Summary: GDF15 plays a crucial role in activating the hypothalamic-pituitary-adrenal (HPA) axis; It is essential for the protective HPA response to toxins that do not induce a substantial cytokine response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: The study found an inverse linear relationship between fetal growth and HPA-A function at age 18, with no consistent quadratic relationships identified. Removal of anticipatory responders from the models substantially attenuated the observed relationships. This suggests altered adrenal sensitivity may underlie the relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: A study found an inverse linear relationship between fetal growth and HPA-A function at the age of 18, which may be related to altered adrenal sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Geriatrics & Gerontology
Agnes Martin, Josiane Castells, Valentine Allibert, Andrea Emerit, Cindy Zolotoff, Victoire Cardot-Ruffino, Yann S. Gallot, Barbara Vernus, Veronique Chauvet, Laurent Bartholin, Laurent Schaeffer, Anne-Cecile Durieux, Christophe Hourde, Francois B. Favier, Laetitia Mazelin, Damien Freyssenet
Summary: This study found that the hypothalamic-pituitary-adrenal-glucocorticoid pathway plays an important role in the transcriptional regulation of skeletal muscle catabolism and hepatic metabolism during cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
Robert Kumsta, David Kliegel, Michael Linden, Roel DeRijk, E. Ron de Kloet
PSYCHONEUROENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Edo R. de Kloet, Sybren F. de Kloet, Carien S. de Kloet, Annette D. de Kloet
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Behavioral Sciences
Jelle Knop, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, Marian Joels, Rixt van der Veen
GENES BRAIN AND BEHAVIOR
(2020)
Review
Biochemistry & Molecular Biology
Alejandro F. De Nicola, Maria Meyer, Rachida Guennoun, Michael Schumacher, Hazel Hunt, Joseph Belanoff, E. Ronald de Kloet, Maria Claudia Gonzalez Deniselle
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Psychology, Developmental
Jiska Kentrop, Aikaterini Kalamari, Chiara Hinna Danesi, John J. Kentrop, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, Marian Joels, Rixt van der Veen
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2020)
Article
Neurosciences
Milou S. C. Sep, Marian Joels, Elbert Geuze
Summary: This study investigates the individual characteristics that affect memory contextualization after stress. The results show that factors such as life adversity, trait anxiety, salivary cortisol level, and alpha-amylase reactivity are related to memory contextualization during different stages of the stress response.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Marc L. Molendijk, E. Ronald de Kloet
Summary: The immobility response in the forced swim test is not considered a rodent model of depression, but it can predict a compound's antidepressant potential to some extent. Despite some papers labeling immobility as depression-like behavior, the perspective on this issue varies among different countries.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Letter
Neurosciences
Edo Ronald de Kloet, Marc L. Molendijk
BIOLOGICAL PSYCHIATRY
(2021)
Editorial Material
Rehabilitation
Riemer J. K. Vegter, Helco G. van Keeken, Sonja de Groot, Han J. P. Houdijk, Marian Joels, Lucas H. V. van der Woude
DISABILITY AND REHABILITATION
(2021)
Review
Multidisciplinary Sciences
Heike Schuler, Valeria Bonapersona, Marian Joels, R. Angela Sarabdjitsingh
Summary: Early-life adversity causes long-lasting changes to the brain that increase vulnerability to psychopathologies later in life. Immediate-early genes (IEGs) can serve as markers for these alterations, connecting activity-regulated transcription to long-term effects on brain structure and function. A systematic review of 39 pre-clinical studies in rodents found that ELA (alteration of maternal care) affected IEG expression, particularly in relation to cFos expression after acute stressors and at rest. These findings suggest that ELA creates a phenotype similar to naive, acutely stressed animals.
Review
Biochemistry & Molecular Biology
E. Ronald de Kloet, Marian Joels
Summary: The glucocorticoid hormones cortisol and corticosterone play a role in promoting resilience by activating mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) of the hypothalamus-pituitary-adrenal (HPA) axis. MR facilitates memory retrieval and stress-coping selection, while GR promotes recovery and cognitive control over emotional reactivity. The balance between MR and GR activation is important for resilience, and disruptions in this balance may lead to chronic stress and increased vulnerability. Novel modulators of MR and GR may help reinstate cognitive flexibility required for resilience.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Multidisciplinary Sciences
Benjamin Deneen
Summary: Analysis of an invasive brain cancer indicates that networks of tumor cells are connected to small groups of 'pacemaker' cells, where calcium ion levels pulsate periodically, driving a signal through the network that stimulates tumor growth.
Article
Neurosciences
Henk Karst, Wouter J. Droogers, Nelleke van der Weerd, Ruth Damsteegt, Nicky van Kronenburg, R. Angela Sarabdjitsingh, Marian Joels
Summary: Early life stress (ELS) alters the excitation-inhibition-balance (EI-balance) in the mouse brain by influencing the GABA-switch, which is accelerated in ELS mice compared to controls. This accelerated switch is associated with increased expression of the inward chloride transporter NKCC1. Both pre- and postsynaptic chloride homeostasis are affected by this switch, leading to altered glutamatergic transmission.
Review
Behavioral Sciences
Edo Ronald de Kloet
Summary: As the end product of the hypothalamus-pituitary-adrenal (HPA) axis, glucocorticoid hormones coordinate various activities in the body and brain, including energy metabolism and defense reactions. The glucocorticoid feedback paradox in the HPA-axis is examined, highlighting the conditional nature of the excitation/inhibition balance in feedback regulation and the potential of glucocorticoids in resetting the stress response system. Understanding the role of glucocorticoid hormone in resilience and vulnerability during stress is crucial.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Review
Behavioral Sciences
Marian Joels
Summary: Mary Dallman has left a significant legacy in neuroendocrinology, both as a scientist who contributed new concepts and as a role model for women in the field. This article compares her journey as the first female faculty member at UCSF with subsequent generations, discusses the contribution of our labs on rapid corticosteroid actions, and highlights the importance of keeping an open mind in scientific research, a principle advocated by Mary Dallman.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)
