Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction

The Nicotinic Acetylcholine Receptor  5 Subunit Plays a Key Role in Attention Circuitry and Accuracy

(2013) C. D. C. Bailey et al.   JOURNAL OF NEUROSCIENCE

Severe intellectual disability and autistic features associated with microduplication 2q23.1

(2011) Brian HY Chung et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1

(2011) Ekaterina N. Lyukmanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

(2011) Christie D. Fowler et al.   NATURE

A disinhibitory microcircuit for associative fear learning in the auditory cortex

(2011) Johannes J. Letzkus et al.   NATURE

Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula

(2011) Silke Frahm et al.   NEURON

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses

(2011) Julie M. Miwa et al.   NEURON

Mouse Mutants for the Nicotinic Acetylcholine Receptor ß2 Subunit Display Changes in Cell Adhesion and Neurodegeneration Response Genes

(2011) Carol M. Rubin et al.   PLoS One

Nicotinic Acetylcholine Receptor  2 Subunits in the Medial Prefrontal Cortex Control Attention

(2011) K. Guillem et al.   SCIENCE

Nicotine Decreases Food Intake Through Activation of POMC Neurons

(2011) Y. S. Mineur et al.   SCIENCE

Crooked, Coiled and Crimpled are three Ly6-like proteins required for proper localization of septate junction components

(2010) A. Nilton et al.   DEVELOPMENT

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

(2010) K. Becanovic et al.   HUMAN MOLECULAR GENETICS

Lateral Mobility of Nicotinic Acetylcholine Receptors on Neurons Is Determined by Receptor Composition, Local Domain, and Cell Type

(2010) C. C. Fernandes et al.   JOURNAL OF NEUROSCIENCE

Silencing neurotransmission with membrane-tethered toxins

(2010) Sebastian Auer et al.   NATURE METHODS

Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks

(2010) Catherine A. Thorn et al.   NEURON

Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition

(2010) Michael E Hasselmo et al.   NEUROPSYCHOPHARMACOLOGY

Temporal and Regional Regulation of Gene Expression by Calcium-Stimulated Adenylyl Cyclase Activity during Fear Memory

(2010) Lindsay Wieczorek et al.   PLoS One

Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily

(2010) Knut Adermann et al.   PROTEIN SCIENCE

Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex

(2010) H. Morishita et al.   SCIENCE

Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

(2009) Henry A. Lester et al.   AAPS Journal

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

(2009) Nancy L. Saccone et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

(2009) Bryan G. Fry et al.   Annual Review of Genomics and Human Genetics

Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors

(2009) Victor Tsetlin et al.   BIOCHEMICAL PHARMACOLOGY

Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits

(2009) Jennifer A. Davis et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6

(2009) Martin Darvas et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Palmitoylation of Nicotinic Acetylcholine Receptors

(2009) J. K. Alexander et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development

(2009) C. K. Pfeffer et al.   JOURNAL OF NEUROSCIENCE

Prostate Stem Cell Antigen Is an Endogenous lynx1-Like Prototoxin That Antagonizes  7-Containing Nicotinic Receptors and Prevents Programmed Cell Death of Parasympathetic Neurons

(2009) M. Hruska et al.   JOURNAL OF NEUROSCIENCE

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker

(2009) Mark N Wu et al.   NATURE NEUROSCIENCE

Dopamine Enables In Vivo Synaptic Plasticity Associated with the Addictive Drug Nicotine

(2009) Jianrong Tang et al.   NEURON

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

A role for LYNX2 in anxiety-related behavior

(2009) A. B. Tekinay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The three-fingered protein domain of the human genome

(2008) A. Galat   CELLULAR AND MOLECULAR LIFE SCIENCES

PATEGene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity

(2008) Fiana Levitin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway

(2008) Sudha Kumari et al.   JOURNAL OF CELL BIOLOGY

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

(2008) Kimberly L Stark et al.   NATURE GENETICS

In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6∗ Nicotinic Acetylcholine Receptors

(2008) Ryan M. Drenan et al.   NEURON

A Resource for Transcriptomic Analysis in the Mouse Brain

(2008) Charles Plessy et al.   PLoS One

Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression?

(2008) David H. Small   TRENDS IN MOLECULAR MEDICINE

Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease

(2007) Marina et al.   Frontiers in Bioscience-Landmark

Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death

(2007) Dan Zhou et al.   PHYSIOLOGICAL GENOMICS

It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

(2007) M PICCIOTTO et al.   PROGRESS IN NEUROBIOLOGY

Mice Homozygous for the L250T Mutation in the α7 Nicotinic Acetylcholine Receptor Show Increased Neuronal Apoptosis and Die Within 1 Day of Birth

(2003) Avi Orr-Urtreger et al.   JOURNAL OF NEUROCHEMISTRY