Article
Multidisciplinary Sciences
R. Cobiella, S. Quinones, M. Konschake, P. Aragones, X. Leon, T. Vazquez, J. Sanudo, E. Maranillo
Summary: The study analyzed anatomical variations in the level of origin of the carotid bifurcation and diameters of the common, internal, and external carotid arteries. It found that males generally had larger arterial calibres than females, with the left internal carotid artery being larger than the right.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Multidisciplinary
Xia Zhu, Ke Wu, Stephan W. Anderson, Xin Zhang
Summary: Signal-to-noise ratio (SNR) is an important metric for assessing MRI image quality. This study proposes a Helmholtz coil-inspired volumetric wireless resonator that can significantly enhance SNR. Experimental results show that the SNR can be boosted by 5 times or more in the region covering the human knee. This research offers an efficient and practical wireless solution for improving MRI image quality, with potential applications in various imaging fields.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Analytical
Djalma Simoes dos Santos, Fabian Fool, Moein Mozaffarzadeh, Maysam Shabanimotlagh, Emile Noothout, Taehoon Kim, Nuriel Rozsa, Hendrik J. Vos, Johan G. Bosch, Michiel A. P. Pertijs, Martin D. Verweij, Nico de Jong
Summary: In this study, a prototype matrix transducer mounted on top of multiple identical ASICs in a tiled configuration was developed. The transducer has 7680 piezoelectric elements with uniform behavior. It exhibits reasonable center frequency and bandwidth in both transmit and receive modes, and can achieve good imaging capabilities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yao Lu, Ruoyao Cao, Sheng Jiao, Ling Li, Chao Liu, Hailong Hu, Zhuangfei Ma, Yun Jiang, Juan Chen
Summary: This study evaluated the application of black-blood CT in carotid artery wall imaging and confirmed its accuracy in diagnosing stenosis rate and plaque burden of carotid artery. Black-blood CT showed good consistency with CTA and VW-MR in identifying stenosis rate and plaque burden, providing clear visualization of the artery wall, especially for patients with contraindication to MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Lianlian Zhang, Qi Lyu, Wenyan Zhou, Xia Li, Qinggan Ni, Shu Jiang, Guofu Shi
Summary: This study suggests a close relationship between systemic immune-inflammation index (SII) level and vulnerable carotid plaques, plaque characteristics, and severity of acute ischemic stroke (AIS). Elevated SII levels may exacerbate the severity of AIS, especially in stroke patients with vulnerable plaques with ruptured fibrous caps.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dongye Li, Huiyu Qiao, Yongjun Han, Hualu Han, Dandan Yang, Jingli Cao, Huimin Xu, Tao Wang, Yajie Wang, Jun Shen, Xihai Zhao
Summary: This study validates the superiority of SNAP sequence over traditional MP-RAGE sequence in identifying and quantifying carotid intraplaque hemorrhage, as demonstrated by histology.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Hye In Lee, Min Kyoung Kang, Kihwan Hwang, Chae-Yong Kim, Yu Jung Kim, Koung Jin Suh, Byung Se Choi, Gheeyoung Choe, In Ah Kim, Bum-Sup Jang
Summary: This study evaluated the volumetric changes in gray matter after radiotherapy and identified factors strongly associated with volume reduction. The results showed that gray matter volume decreased after radiotherapy, with the greatest reductions observed in the areas responsible for cognition and execution of movement. Female sex and age at radiotherapy were significantly associated with volume reduction, with older patients experiencing greater reductions over time. Individualized treatment and prevention strategies are necessary for susceptible patients.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Hediyeh Baradaran, Ajay Gupta
Summary: Arterial stiffness is an important measure of vascular aging and atherosclerosis, but is often overlooked in clinical practice. Both central arterial stiffness and local carotid stiffness are associated with cerebrovascular processes and cognitive dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Zahabiya Campwala, Benjamin Szewczyk, Teresa Maietta, Rachel Trowbridge, Matthew Tarasek, Chitresh Bhushan, Eric Fiveland, Goutam Ghoshal, Tamas Heffter, Katie Gandomi, Paulo Alberto Carvalho, Christopher Nycz, Erin Jeannotte, Michael Staudt, Julia Nalwalk, Abigail Hellman, Zhanyue Zhao, E. Clif Burdette, Gregory Fischer, Desmond Yeo, Julie G. Pilitsis
Summary: In this study, it was demonstrated through experiments on pigs that using multislice volumetric 2-D magnetic resonance thermal imaging can accurately track thermal changes during MRgRA NBTU, preparing for human trials and improving therapy delivery. The enhanced volumetric coverage with MRTI has significant implications for focused ultrasound in clinical settings.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Clinical Neurology
Kate Sutherland, Aimee B. Lowth, Nick Antic, A. Simon Carney, Peter G. Catcheside, Ching Li Chai-Coetzer, Michael Chia, John-Charles Hodge, Andrew Jones, Billingsley Kaambwa, Richard Lewis, Stuart MacKay, R. Doug McEvoy, Eng H. Ooi, Alison J. Pinczel, Nigel McArdle, Guy Rees, Bhajan Singh, Nicholas Stow, Edward M. Weaver, Richard J. Woodman, Charmaine M. Woods, Aeneas Yeo, Peter A. Cistulli
Summary: The study on Sleep Apnea Multilevel Surgery found that the surgery effectively treats OSA, but there were no significant post-operative volumetric changes associated with OSA improvement 6 months after surgery. The surgery may reduce the need for neuromuscular compensation during wake by improving upper airway structures to improve OSA symptoms. Further research is needed to understand the mechanisms of action of multilevel surgery.
Article
Clinical Neurology
Kate Sutherland, Aimee B. Lowth, Nick Antic, A. Simon Carney, Peter G. Catcheside, Ching Li Chai-Coetzer, Michael Chia, John-Charles Hodge, Andrew Jones, Billingsley Kaambwa, Richard Lewis, Stuart MacKay, R. Doug McEvoy, Eng H. Ooi, Alison J. Pinczel, Nigel McArdle, Guy Rees, Bhajan Singh, Nicholas Stow, Edward M. Weaver, Richard J. Woodman, Charmaine M. Woods, Aeneas Yeo, Peter A. Cistulli
Summary: The study showed that contemporary multilevel upper airway surgery is an effective treatment for obstructive sleep apnea (OSA). However, there were no significant volumetric changes associated with OSA improvement post-surgery, suggesting that the effect on OSA improvement may be achieved without notable deformation of airway volume.
Review
Radiology, Nuclear Medicine & Medical Imaging
Weizhao Lu, Yuanyuan Sun, Hui Gao, Jianfeng Qiu
Summary: The increasing number of women in the perimenopausal phase due to global population ageing highlights the importance of studying the perimenopausal brain. Magnetic resonance imaging (MRI) has been widely used to reveal brain alterations associated with perimenopausal symptoms. This review collects literature on perimenopausal brain using MRI techniques, describes the changes in brain structure, function, perfusion, and metabolic compounds, and provides a perspective on future multi-modal MRI studies in the perimenopausal brain. Further research is needed to address the neural heterogeneity in the perimenopausal brain for precise diagnosis and personalized treatment of perimenopausal symptoms.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemical Research Methods
Wuwei Ren, Xose Luis Dean-Ben, Mark-Aurel Augath, Daniel Razansky
Summary: The study investigates the feasibility of combining optoacoustic tomography (OAT) and magnetic resonance imaging (MRI) to render concurrent images, with the findings showing minimal distortion in MRI images caused by the OAT probe. Synchronization of the laser and MRI pulse sequence, together with good dynamic OAT contrast from superparamagnetic iron oxide nanoparticles, provides an excellent platform for cross-validating functional readings of both imaging modalities.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yumeng Sun, Haiyang Xu, Lei Kou, Shuo Wang, Zhenjia Wang, Wei Yu
Summary: This study investigated the imaging findings associated with the stent expansion rate (SER) of the carotid artery. It found that calcified plaques are associated with SER, and the calcification circumference is correlated with the SER of open-cell stents. Additionally, the calcification circumference, area, and location are related to the SER of closed-cell stents.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yumeng Sun, Haiyang Xu, Lei Kou, Shuo Wang, Zhenjia Wang, Wei Yu
Summary: This study investigates the association between plaque imaging findings and the stent expansion rate (SER) of the carotid artery. The results suggest that calcified plaques are associated with SER, with calcification circumference being correlated with SER in open-cell stents and calcification circumference, calcification area, and calcification location being related to SER in closed-cell stents. These findings provide important considerations for clinicians when choosing carotid artery stents.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neuroimaging
Mehdi Najafi, Nicole M. Cancelliere, Olivier Brina, Pierre Bouillot, Maria Vargas, Benedicte Ma Delattre, Vitor M. Pereira, David A. Steinman
Summary: The study tested the impact of relying on generalized inflow rates and found that adjusting the generalized waveform shape with patient-specific Qavg can achieve near-perfect agreement and improve OSI correlations.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Neuroimaging
Vitor M. Pereira, Nicole Mariantonia Cancelliere, Mehdi Najafi, Dan MacDonald, Thangam Natarajan, Ivan Radovanovic, Timo Krings, John Rutka, Patrick Nicholson, David A. Steinman
Summary: This study demonstrates that turbulence generated distal to a venous stenosis can be a cause of PT. High-fidelity CFD may be useful in identifying patients with such 'torrents' of flow, helping guide treatment decision-making.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Biophysics
Rayanne Pinto Costa, Blaise Simplice Talla Nwotchouang, Junyao Yao, Dipankar Biswas, David Casey, Ruel McKenzie, David A. Steinman, Francis Loth
Summary: In this study, the critical Reynolds numbers for the transition to turbulence were experimentally determined for whole porcine blood and a Newtonian blood analog. The results showed that the transition to turbulence was delayed by approximately 19% for whole blood compared to the Newtonian fluid. This finding suggests that the rheological properties of blood may play a role in suppressing or delaying the onset of turbulence in vivo.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Art
Dolores A. Steinman, Peter W. Coppin, David A. Steinman
Summary: The case study demonstrates how the authors integrated blood-flow dynamics and visual arts, and achieved innovative interdisciplinary outcomes through close collaboration between engineering students and artists.
Article
Biology
Kristen M. Meiburger, Francesco Marzola, Guillaume Zahnd, Francesco Faita, Christos P. Loizou, Nolann Laine, Catarina Carvalho, David A. Steinman, Lorenzo Gibello, Rosa Maria Bruno, Ricarda Clarenbach, Martina Francesconi, Andrew N. Nicolaides, Herve Liebgott, Aurelio Campilho, Reza Ghotbi, Efthyvoulos Kyriacou, Nassir Navab, Maura Griffin, Andrie G. Panayiotou, Rachele Gherardini, Gianfranco Varetto, Elisabetta Bianchini, Constantinos S. Pattichis, Lorenzo Ghiadoni, Jose Rouco, Maciej Orkisz, Filippo Molinari
Summary: This study presents technical outlooks on computerized carotid intima-media thickness (CIMT) measurements and provides considerations for the development and comparison of these methods. A multi-center database of 500 images was collected and three manual segmentations and seven computerized methods were employed to measure the CIMT. The computerized methods showed comparable results with previous studies and demonstrated promising segmentation outcomes. The entire database has been made publicly available for further research and comparison.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biophysics
Daniel E. MacDonald, Mehdi Najafi, Lucas Temor, David A. Steinman
Summary: Recent studies have found high-frequency flow instabilities in aneurysms consistent with clinical reports. This study introduces a novel method for quantifying and visualizing these instabilities in cardiovascular computational fluid dynamics (CFD) data. The results show that a spectral bandedness index (SBI) is significantly associated with rupture status and could potentially be used to identify aneurysms at lower risk of rupture.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Biophysics
M. O. Khan, V. Toro Arana, M. Najafi, D. E. MacDonald, T. Natarajan, K. Valen-Sendstad, D. A. Steinman
Summary: High-fidelity computational fluid dynamics (HF-CFD) reveals the potential for high-frequency flow instabilities in intracranial aneurysms. While high SPI values do not significantly predict rupture status, it is important not to overlook these instabilities for a better understanding of the dynamic mechanical forces on aneurysm walls.
JOURNAL OF BIOMECHANICS
(2021)
Article
Physics, Fluids & Plasmas
Thangam Natarajan, Daniel E. MacDonald, Lucas Temor, Peter W. Coppin, David A. Steinman
Summary: This paper is associated with a poster winner of the 2020 Milton van Dyke Award from the American Physical Society's Division of Fluid Dynamics, which was presented at the DFD Gallery of Fluid Motion. The original poster can be viewed online at the Gallery of Fluid Motion website.
PHYSICAL REVIEW FLUIDS
(2021)
Article
Neuroimaging
Daniel E. MacDonald, Nicole M. Cancelliere, Arianna Rustici, Vitor M. Pereira, David A. Steinman
Summary: This study presents a novel method called SURGE for extracting high curvature features from 3DRA images, which can reduce neck width estimation errors. Compared with traditional methods, SURGE provides a more accurate, faster, and more objective approach.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Computer Science, Interdisciplinary Applications
Valentina Mazzi, Giuseppe De Nisco, Karol Calo, Claudio Chiastra, Joost Daemen, David A. Steinman, Jolanda J. Wentzel, Umberto Morbiducci, Diego Gallo
Summary: This study aimed to infer the near-wall transport of low-density lipoproteins (LDL) in arteries by computing wall shear stress (WSS). The results indicated that WSS topological skeleton features were more effective in identifying LDL concentration polarization profiles and showed promising correspondence with in vivo measured wall thickness growth in coronary arteries.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Biophysics
Rayanne Pinto Costa, Blaise Simplice Talla Nwotchouang, Junyao Yao, Dipankar Biswas, David Casey, Ruel McKenzie, Frederick Sebastian, Rouzbeh Amini, David A. Steinman, Francis Loth
Summary: This study investigated the impact of wall compliance on the transition to turbulence in blood compared to a Newtonian fluid. The results showed that there were no significant differences in the wall vibration between whole blood and the Newtonian fluid, indicating that rheology had minimal impact on the vibration downstream of a stenosis for transition to turbulence.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel E. MacDonald, Nicole M. Cancelliere, Vitor M. Pereira, David A. Steinman
Summary: The overestimation of intracranial aneurysm neck width has minimal impact on hemodynamics derived from computational fluid dynamics (CFD), with the differences being at most equal to or less than those caused by other sources of error/uncertainty in CFD analysis.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Biophysics
David A. Bruneau, Kristian Valen-Sendstad, David A. Steinman
Summary: Clinical, experimental, and computational studies have found that vibrations in cerebral aneurysms induced by blood flow instability could lead to wall deformation and cell behavior disruption. This study imposed increasing flow rates on realistic aneurysm models and observed narrow-band vibrations in two out of three geometries tested, with the strongest vibrations occurring when the fluid frequency band matched one of the aneurysm sac's natural frequencies. The study provides a potential mechanistic explanation for the high-frequency sounds in cerebral aneurysms and suggests that narrow-band flow might stimulate the aneurysm wall more effectively than broad-band, turbulent-like flow.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Olga V. Fedorova, Victoria Y. Shilova, Valentina Zernetkina, Ondrej Juhasz, Wen Wei, Edward G. Lakatta, Alexei Y. Bagrov
Summary: In this study, it was found that vascular smooth muscle cells (VSMC) from old rats exhibited heightened sensitivity to the profibrotic effect of marinobufagenin due to downregulation of ANP/cGMP/PKG-dependent signaling. The reduction in vascular PKG1 and cGMP signaling with age resulted in the loss of the ability of ANP to oppose the inhibitory effect of marinobufagenin on NKA and fibrosis development.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Engineering, Biomedical
Lucas Temor, Nicole M. Cancelliere, Daniel E. MacDonald, Peter W. Coppin, Vitor M. Pereira, David A. Steinman
Summary: Translating CFD data to DICOM series enables interactive visualization in standard radiological software. Our approach allows real-time modifications of transfer functions for representations of scalar isosurfaces, volumetric rendering, and tubular pathlines.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)