Journal
PHYSIOLOGICAL MEASUREMENT
Volume 31, Issue 12, Pages 1553-1565Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0967-3334/31/12/001
Keywords
aging; mechanical properties; anisotropy; tensile strength; arterial wall
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Funding
- Comunidad de Madrid [MADR.IB-CM/S-SAL/0312/2006]
- Banco Santander and UPM
- Universidad de Santiago de Chile (USACH)
- Chilean Council of Research and Technology (CONICYT) [11090266]
- Fundacion Marcelino Botin
- Fundacion Agustin de Betancourt in Spain
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In recent times, significant effort has been made to understand the mechanical behaviour of the arterial wall and how it is affected by the different vascular pathologies. However, to be able to interpret the results correctly, it is essential that the influence of other factors, such as aging or anisotropy, be understood. Knowledge of mechanical behaviour of the aorta has been customarily constrained by lack of data on fresh aortic tissue, especially from healthy young individuals. In addition, information regarding the point of rupture is also very limited. In this study, the mechanical behaviour of the descending thoracic aorta of 28 organ donors with no apparent disease, whose ages vary from 17 to 60 years, is evaluated. Tensile tests up to rupture are carried out to evaluate the influence of age and wall anisotropy. Results reveal that the tensile strength and stretch at failure of healthy descending aortas show a significant reduction with age, falling abruptly beyond the age of 30. This fact places age as a key factor when mechanical properties of descending aorta are considered.
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