Article
Oncology
Yanqiong Liu, Qiulian Wu, Fuyong Zhang, Xue Qin
Summary: This study provides evidence for the first time that the NRF2 gene rs6721961 variation is a potential genetic marker for susceptibility to hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Shuang Zhao, Tianyu Song, Yue Gu, Yihua Zhang, Siyi Cao, Qing Miao, Xiyue Zhang, Hongshan Chen, Yuanqing Gao, Lei Zhang, Yi Han, Hong Wang, Jun Pu, Liping Xie, Yong Ji
Summary: The study suggests that H2S alleviates liver damage by activating Keap1 S-sulfhydration and promoting the activation of Nrf2, leading to increased expression of antioxidant proteins, which may have potential therapeutic benefits for liver diseases.
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Respiratory System
Yong Suk Jo, Ji-Yong Moon, Yong Bum Park, Yee Hyung Kim, Soo-Jung Um, Woo Jin Kim, Hyoung Kyu Yoon, Kwang Ha Yoo, Ki-Suck Jung, Chin Kook Rhee
Summary: This study investigated the longitudinal changes in lung function in eosinophilic COPD patients and the effects of inhaled corticosteroid (ICS) therapy. The results showed that eosinophilic COPD had a more favorable annual rate of decline in forced expiratory volume in 1 s (FEV1) compared to non-eosinophilic COPD, and ICS therapy did not have any beneficial effects on the changes in FEV1.
BMC PULMONARY MEDICINE
(2022)
Article
Oncology
Fei Chen, Sungshim L. Park, Lynne R. Wilkens, Peggy Wan, Steven N. Hart, Chunling Hu, Siddhartha Yadav, Fergus J. Couch, David V. Conti, Adam J. de Smith, Christopher A. Haiman
Summary: This multiethnic study found that germline pathogenic variants in BRCA1, BRCA2, and ERCC2 are associated with the development of second primary cancer in breast cancer survivors, providing biological insights and biomarkers for patient monitoring.
Article
Cell Biology
David Rysanek, Pavla Vasicova, Jayaprakash Narayana Kolla, David Sedlak, Ladislav Andera, Jiri Bartek, Zdenek Hodny
Summary: The accumulation of senescent cells in aging tissues contributes to age-associated diseases. Inhibiting the anti-apoptotic machinery of senescent cells through BCL-2 protein family inhibitors can eliminate these cells. Combination therapy with BCL-2 inhibitors shows synergistic effects in eliminating senescent cells and overcoming resistance to monotherapy.
Article
Fisheries
Yun Wang, Yafei Duan, Jianhua Huang, Jun Wang, Chuanpeng Zhou, Shigui Jiang, Heizhao Lin, Zhe Zhang
Summary: PmNrf2, a member of CNC-bZIP transcription factor family, is constitutively expressed in various tissues of shrimp and responds to bacterial challenge. Knockdown of PmNrf2 results in decreased expression of PmGPx gene, indicating its role in regulating the transcription of antioxidant enzyme genes in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Environmental Sciences
Yuan-yuan Wei, Hui-ru Wang, Yi-meng Fan, Jin-hua Gu, Xiu-ying Zhang, Xu-hao Gong, Zhi-hui Hao
Summary: The study evaluated the effect and underlying mechanism of GDK aqueous extract in alleviating acute liver injury caused by CCl4. The results showed that GDK effectively inhibited liver damage and restored the structure and function of the liver. It achieved this by suppressing liver fibrosis, blocking the NFicB pathway, inhibiting hepatic inflammatory response, reducing oxidative stress, inhibiting ferroptosis, and alleviating hepatocyte injury caused by CCl4. In conclusion, this study provides insights into the potential complex mechanism of GDK against acute liver injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biotechnology & Applied Microbiology
Huiyan Deng, Miaojian Wan, Huaping Li, Quan Chen, Runxiang Li, Bihua Liang, Huilan Zhu
Summary: The study demonstrates that curcumin can protect the skin from UV damage by regulating the Nrf2 pathway. UV irradiation leads to cell apoptosis and oxidative stress, which can be reversed by adding curcumin. Additionally, curcumin induces Nrf2 nuclear accumulation in Hacat cells to provide protection against UV exposure-induced photodamage.
Article
Plant Sciences
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li
Summary: This study found that 15, 16-Dihydrotanshinone I (DHT) can protect against ferroptosis and ischemic stroke by activating the Nrf2 signaling pathway.
Review
Gastroenterology & Hepatology
Vidyasagar Naik Bukke, Archana Moola, Gaetano Serviddio, Gianluigi Vendemiale, Francesco Bellanti
Summary: Oxidative stress is a key driver in the development and progression of various diseases, including MAFLD. NRF2, a master regulator of redox homeostasis, plays a crucial role in every step of MAFLD development. NRF2 activators regulate lipid metabolism and oxidative stress, alleviating fatty liver disease by inducing the expression of cytoprotective genes.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Respiratory System
Sinjini Sikdar, Annah B. Wyss, Mi Kyeong Lee, Thanh T. Hoang, Marie Richards, Laura E. Beane Freeman, Christine Parks, Peter S. Thorne, John L. Hankinson, David M. Umbach, Alison Motsinger-Reif, Stephanie J. London
Summary: This study evaluated the impact of gene-environment interactions on pulmonary function using Genetic Risk Scores (GRSs). The results suggest that increased genetic susceptibility has a greater impact on reduced pulmonary function in the presence of smoking or asthma.
Article
Respiratory System
Debby Ngo, Katherine A. Pratte, Claudia Flexeder, Hans Petersen, Hong Dang, Yanlin Ma, Michelle J. Keyes, Yan Gao, Shuliang Deng, Bennet D. Peterson, Laurie A. Farrell, Victoria M. Bhambhani, Cesar Palacios, Juweria Quadir, Lucas Gillenwater, Hanfei Xu, Claire Emson, Christian Gieger, Karsten Suhre, Johannes Graumann, Deepti Jain, Matthew P. Conomos, Russell P. Tracy, Xiuqing Guo, Yongmei Liu, W. Craig Johnson, Elaine Cornell, Peter Durda, Kent D. Taylor, George J. Papanicolaou, Stephen S. Rich, Jerome I. Rotter, Steven I. Rennard, Jeffrey L. Curtis, Prescott G. Woodruff, Alejandro P. Comellas, Edwin K. Silverman, James D. Crapo, Martin G. Larson, Ramachandran S. Vasan, Thomas J. Wang, Adolfo Correa, Mario Sims, James G. Wilson, Robert E. Gerszten, George T. O'Connor, R. Graham Barr, David Couper, Josee Dupuis, Ani Manichaikul, Wanda K. O'Neal, Yohannes Tesfaigzi, Holger Schulz, Russell P. Bowler
Summary: This study identifies and validates novel protein markers and pathways associated with lung function impairment in a diverse population. The findings highlight the potential for risk assessment and treatment of COPD based on these biomarkers.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
Summary: Propofol can reduce myocardial I/R injury by activating PKC/NRF2 pathway, leading to increased antioxidant enzyme expression and decreased levels of lactate dehydrogenase and creatine kinase-MB.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Infectious Diseases
Meng Zhang, Miao Xue, Jian-qing He
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Review
Pharmacology & Pharmacy
Meng Zhang, Jian-qing He
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Guiyi Ji, Weiwei Huang, Jianqing He
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Cardiac & Cardiovascular Systems
Ryszard Nosalski, Mateusz Siedlinski, Laura Denby, Eilidh McGinnigle, Michal Nowak, Aurelie Nguyen Dinh Cat, Laura Medina-Ruiz, Marco Cantini, Dominik Skiba, Grzegorz Wilk, Grzegorz Osmenda, Julie Rodor, Manuel Salmeron-Sanchez, Gerard Graham, Pasquale Maffia, Delyth Graham, Andrew H. Baker, Tomasz J. Guzik
CIRCULATION RESEARCH
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Mateusz Siedlinski, David G. Harrison, Tomasz J. Guzik
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Mateusz Siedlinski, Ewelina Jozefczuk, Xiaoguang Xu, Alexander Teumer, Evangelos Evangelou, Renate B. Schnabel, Paul Welsh, Pasquale Maffia, Jeanette Erdmann, Maciej Tomaszewski, Mark J. Caulfield, Naveed Sattar, Michael V. Holmes, Tomasz J. Guzik
Article
Pharmacology & Pharmacy
Mingjin Yang, Yan Zhang, Hong Cheng, Zhibo Xu, Jianqing He
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shouquan Wu, Xiangmin Liu, Ling Chen, Yu Wang, Miaomiao Zhang, Minggui Wang, Jian-Qing He
BIOSCIENCE REPORTS
(2020)
Review
Pharmacology & Pharmacy
E. Jozefczuk, T. J. Guzik, M. Siedlinski
PHARMACOLOGICAL RESEARCH
(2020)
Letter
Cardiac & Cardiovascular Systems
Mateusz Siedlinski, Michael V. Holmes, Tomasz J. Guzik
Article
Respiratory System
Miaomiao Zhang, Guo Chen, Yu Wang, Shou-Quan Wu, Andrew J. Sandford, Jian-Qing He
BMC PULMONARY MEDICINE
(2020)
Review
Pharmacology & Pharmacy
Shiv Sharma, Swathi Sridhar, Alasdair McIntosh, Claudia-Martina Messow, Eva Munoz Aguilera, Rita Del Pinto, Davide Pietropaoli, Renata Gorska, Mateusz Siedlinski, Pasquale Maffia, Maciej Tomaszewski, Tomasz J. Guzik, Francesco D'Aiuto, Marta Czesnikiewicz-Guzik
Summary: The study compared the effects of intensive periodontal treatment and conventional periodontal treatment on arterial blood pressure, endothelial function, and inflammatory/metabolic biomarkers. The results showed that intensive periodontal treatment improved cardiovascular health in hypertensive and prehypertensive individuals, with no significant effect observed in normotensive individuals.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dominik S. Skiba, Piotr Szczepaniak, Mateusz Siedlinski, Piotr Poznanski, Marzena Lazarczyk, Kinga Jaskula, Piotr Religa, Mariusz Sacharczuk, Zbigniew Gaciong
Summary: The study revealed that individuals with low endogenous opioid system activity have higher basal blood pressure, while naloxone only elevates blood pressure in individuals with high endogenous opioid system activity. In addition, low opioid system activity contributes to impaired vascular relaxation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ewelina Jozefczuk, Piotr Szczepaniak, Tomasz Jan Guzik, Mateusz Siedlinski
Summary: The silencing of Sphk1 in neonatal mouse CMs was shown to enhance their postnatal maturation in both physiological and stress conditions, as evidenced by accelerated cell maturation, inhibition of proliferation, and induction of developmental pathways. This effect was further supported by the upregulation of the Akt signaling pathway and downregulation of Gsk3β, indicating physiological hypertrophy in the absence of Sphk1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Grzegorz Osmenda, Pawel T. Matusik, Tomasz Sliwa, Marta Czesnikiewicz-Guzik, Jan Skupien, Maciej T. Malecki, Mateusz Siedlinski
Summary: The C242T polymorphism of the CYBA gene is significantly associated with endothelial dysfunction in patients with T2DM, making it a potentially useful marker for this condition.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2021)