Journal
ARQUIVOS DE NEURO-PSIQUIATRIA
Volume 73, Issue 11, Pages 899-902Publisher
ASSOC ARQUIVOS NEURO- PSIQUIATRIA
DOI: 10.1590/0004-282X20150137
Keywords
IL-6; polymorphism; cognitive impairment no dementia; cognition
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Funding
- FAPEMIG
- CNPq
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Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6-174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up. Methods: The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups. Results: We observed that individuals with cognitive impairment no dementia with GG(lower) genotype were more frequent among global cognitive score non-decliners while carriers of at least one C-higher allele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC95% = 1.087-8.812). Conclusion: These results suggest that the higher expression of IL- 6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia.
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