Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 59, Issue 2, Pages R65-R127Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/59/2/R65
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Funding
- NIH [P50-CA92629, P01-CA94060, RC2CA148971, P30 CA08748]
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This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High-field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include H-1, P-31, chemical exchange saturation transfer imaging and hyperpolarized C-13 MRS as well as diffusion-weighted, blood oxygen level dependent contrast imaging and dynamic contrast-enhanced MRI. These methods have been proven effective in animal studies and are highly relevant to human clinical studies.
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