Article
Neurosciences
Michiel Cottaar, Matteo Bastiani, Nikhil Boddu, Matthew F. Glasser, Suzanne Haber, David C. van Essen, Stamatios N. Sotiropoulos, Saad Jbabdi
Summary: Many brain imaging studies measure structural connectivity with diffusion tractography, but biases in the data can limit accuracy. A new algorithm reduces these biases by modeling fiber density and orientation.
Article
Multidisciplinary Sciences
Sian Wilson, Maximilian Pietsch, Lucilio Cordero-Grande, Anthony N. Price, Jana Hutter, Jiaxin Xiao, Laura McCabe, Mary A. Rutherford, Emer J. Hughes, Serena J. Counsell, Jacques-Donald Tournier, Tomoki Arichi, Joseph V. Hajnal, A. David Edwards, Daan Christiaens, Jonathan O'Muircheartaigh
Summary: A study characterizing the in utero maturation of white matter microstructure in human fetal brains using high-resolution MRI data identified unique maturational trends in different white matter bundles and regions, suggesting potential insights into connectivity abnormalities associated with preterm birth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Mengxing Liu, Garikoitz Lerma-Usabiaga, Francisco Clasca, Pedro M. Paz-Alonso
Summary: In this study, a reconstruction protocol based on in vivo diffusion MRI was developed to extract and measure specific axonal fiber tracts in individual first-order relay nuclei. The protocol demonstrated high computational and test-retest reproducibility. This new protocol is significant for both basic human brain neuroscience and clinical studies.
Article
Neurosciences
Sendy Caffarra, Sung Jun Joo, David Bloom, John Kruper, Ariel Rokem, Jason D. Yeatman
Summary: The latency of neural responses in the visual cortex varies across the lifespan, with faster M100 responses for high contrast stimuli observed with age, where optic radiation FA values mediate this effect.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Ahmed M. Radwan, Stefan Sunaert, Kurt Schilling, Maxime Descoteaux, Bennett A. Landman, Mathieu Vandenbulcke, Tom Theys, Patrick Dupont, Louise Emsell
Summary: The virtual dissection of white matter using diffusion MRI tractography has poor reproducibility, but this study provides a comprehensive description of white matter anatomy using a reproducible automated subject-specific parcellation-based approach with probabilistic CSD tractography. The study demonstrates high inter-session similarity and provides a WM atlas that can be useful for mapping white matter fasciculi in healthy adults.
Article
Neurosciences
Nicole E. Neef, Alexandra Korzeczek, Annika Primassin, Alexander Wolff von Gudenberg, Peter Dechent, Christian Heiner Riedel, Walter Paulus, Martin Sommer
Summary: Persistent stuttering is a common neurodevelopmental speech disorder that is often associated with cortical alterations and dysfunctional neural pathways. Therapy may impact different brain structures related to speech motor performance and social-emotional burden in individuals with persistent stuttering.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Harm Jan van der Horn, Namrata R. Mangina, Sandra E. Rakers, Jelmer G. Kok, Marieke E. Timmerman, Alexander Leemans, Jacoba M. Spikman, Joukje van Der Naalt
Summary: This longitudinal tractography study found microstructural changes in emotion regulation tracts among patients with mild traumatic brain injury, particularly in those without complications. However, the presence of symptoms could not be explained by these changes.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Muhamed Barakovic, Gabriel Girard, Simona Schiavi, David Romascano, Maxime Descoteaux, Cristina Granziera, Derek K. Jones, Giorgio M. Innocenti, Jean-Philippe Thiran, Alessandro Daducci
Summary: Our novel microstructure-informed tractography approach, COMMITAxSize, resolves axon diameter index estimates at the streamline level, providing invariant estimates along trajectories. By jointly estimating tissue microstructure properties and macroscopic white matter connectivity organization, our method offers a more robust estimation of axon diameter index for pathways compared to existing methods. We demonstrate the efficacy of our approach by comparing estimates with histologically-derived measurements in specific brain regions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Simona Schiavi, Po-Jui Lu, Matthias Weigel, Antoine Lutti, Derek K. Jones, Ludwig Kappos, Cristina Granziera, Alessandro Daducci
Summary: This study introduces a new method called myelin streamline decomposition (MySD), which extends convex optimization modeling to microstructure informed tractography (COMMIT), allowing the deconvolution of the actual value measured by a microstructural map on each individual streamline to recover unique bundle specific myelin fractions (BMFs).
Article
Anatomy & Morphology
Kurt G. Schilling, Derek Archer, Fang-Cheng Yeh, Francois Rheault, Leon Y. Cai, Colin Hansen, Qi Yang, Karthik Ramdass, Andrea T. Shafer, Susan M. Resnick, Kimberly R. Pechman, Katherine A. Gifford, Timothy J. Hohman, Angela Jefferson, Adam W. Anderson, Hakmook Kang, Bennett A. Landman
Summary: This study examines the microstructural and macrostructural features of white matter in the aging brain using diffusion magnetic resonance imaging. The findings show that microstructure and macrostructure features are both affected by age, but macrostructure features demonstrate more heterogeneity across different pathways. This suggests that macrostructural features may be more sensitive indicators of white matter decline and can be used in studying aging and various diseases or conditions.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Anatomy & Morphology
Victor Nozais, Guillaume Theaud, Maxime Descoteaux, Michel Thiebaut de Schotten, Laurent Petit
Summary: This article introduces a structural-functional approach, Functionnectome, which combines fMRI acquisition with tractography-derived white matter connectivity data to map cognitive processes onto the white matter. However, this approach faces three challenges, and the authors propose solutions and improve the characterization of white matter involvement.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Neurosciences
Gianpaolo Antonio Basile, Salvatore Bertino, Victor Nozais, Alessia Bramanti, Rosella Ciurleo, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola
Summary: This study used the track-weighted dynamic functional connectivity model to investigate the contribution of structural connectivity to functional connectivity dynamics. The results showed that this model can provide functional information about white matter activity, capturing meaningful features of brain connectivity organization and predicting higher-order cognitive performance.
Article
Neurosciences
Peng Zhang, Guocan Gu, Yunyun Duan, Zhizheng Zhuo, Changcun Pan, Pengcheng Zuo, Yi Wang, Xiaoou Li, Zhuang Jiang, Liying Qu, Yaou Liu, Liwei Zhang
Summary: This study assessed alterations in white matter (WM) of patients with brainstem glioma (BSG) using diffusion kurtosis imaging (DKI) techniques, identifying significant WM abnormalities compared to healthy controls, particularly in fibers away from tumor location. Statistical analyses revealed a correlation between the severity of WM abnormalities and patients' symptom duration and preoperative Karnofsky Performance Scale (KPS) scores.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Christienne G. Damatac, Roselyne J. M. Chauvin, Marcel P. Zwiers, Daan van Rooij, Sophie E. A. Akkermans, Jilly Naaijen, Pieter J. Hoekstra, Catharina A. Hartman, Jaap Oosterlaan, Barbara Franke, Jan K. Buitelaar, Christian F. Beckmann, Emma Sprooten
Summary: This study found that lower fractional anisotropy (FA) in the right cingulum angular bundle was associated with higher hyperactivity-impulsivity symptom severity in patients with attention-deficit/hyperactivity disorder (ADHD), however, no evidence was found for altered FA in association with ADHD diagnosis or impairment. The associations of FA with ADHD symptom severity were not uniformly distributed across white matter tracts.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francois Rheault, Roza G. Bayrak, Xuan Wang, Kurt G. Schilling, Jasmine M. Greer, Colin B. Hansen, Cailey Kerley, Karthik Ramadass, Lucas W. Remedios, Justin A. Blaber, Owen Williams, Lori L. Beason-Held, Susan M. Resnick, Baxter P. Rogers, Bennett A. Landman
Summary: Reproducible identification of white matter pathways across subjects is essential for studying structural connectivity of the human brain. By quantifying the reproducibility of a segmentation protocol, researchers established a baseline, identified limitations for future iterations, and highlighted the importance of consensus on anatomical descriptions of white matter pathways.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Giulia Berto, Daniel Bullock, Pietro Astolfi, Soichi Hayashi, Luca Zigiotto, Luciano Annicchiarico, Francesco Corsini, Alessandro De Benedictis, Silvio Sarubbo, Franco Pestilli, Paolo Avesani, Emanuele Olivetti
Summary: This study introduces a novel supervised fiber segmentation method called Classifyber, which combines information from atlases, connectivity patterns, and the geometry of fiber paths into a simple linear model. Through experiments on multiple datasets, it is demonstrated that Classifyber substantially improves segmentation quality compared to other state-of-the-art methods and is robust across diverse settings. The proposed method is provided as open-source code and a web service.
Article
Multidisciplinary Sciences
Ilaria Sani, Heiko Stemmann, Bradley Caron, Daniel Bullock, Torsten Stemmler, Manfred Fahle, Franco Pestilli, Winrich A. Freiwald
Summary: Endogenous attention is controlled by dorsal fronto-parietal brain areas, but can also be modulated by a control attention area located in the temporal lobe. This area is functionally distinct and connected to parietal and frontal attentional regions, suggesting a different organizing principle for cognitive control.
NATURE COMMUNICATIONS
(2021)
Article
Computer Science, Cybernetics
Jacqueline M. Fulvio, Mohan Ji, Bas Rokers
Summary: This study found that sensitivity to visual cues predicts the severity of motion sickness symptoms. The research also explored another reported source of variability in motion sickness severity in VR, sex, but found little support for it. Previously reported sex differences in motion sickness severity in VR might be due to poor personalization of VR displays.
ENTERTAINMENT COMPUTING
(2021)
Article
Neurosciences
Lowell W. Thompson, Byounghoon Kim, Zikang Zhu, Bas Rokers, Ari Rosenberg
Summary: Results show that there are differences in the integration of left- and right-eye perspective cues and stereoscopic cues in three-dimensional motion perception, suggesting that signals undergoing independent neural processing can influence 3-D perception.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Shiloh L. Echevarria-Cooper, Guangyu Zhou, Christina Zelano, Franco Pestilli, Todd B. Parrish, Thorsten Kahnt
Summary: The human sense of smell plays a crucial role in appetite, detecting threats, social interactions, and memory processing. In this study, we used a novel dMRI method to investigate the connectivity of the human olfactory tracts. Our results revealed an association between the structural integrity of the olfactory tracts and olfactory perceptual function.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Emily J. Allen, Ghislain St-Yves, Yihan Wu, Jesse L. Breedlove, Jacob S. Prince, Logan T. Dowdle, Matthias Nau, Brad Caron, Franco Pestilli, Ian Charest, J. Benjamin Hutchinson, Thomas Naselaris, Kendrick Kay
Summary: The Natural Scenes Dataset (NSD) collected neural activity data during rich cognitive phenomena and built deep neural network models that predict brain activity more accurately than state-of-the-art computer vision models. The dataset also includes resting-state and diffusion data, providing new perspectives for the study of perception and memory models.
NATURE NEUROSCIENCE
(2022)
Review
Neurosciences
Damian O. Eke, Amy Bernard, Jan G. Bjaalie, Ricardo Chavarriaga, Takashi Hanakawa, Anthony J. Hannan, Sean L. Hill, Maryann E. Martone, Agnes McMahon, Oliver Ruebel, Sharon Crook, Edda Thiels, Franco Pestilli
Summary: With the increase in neuroscience projects on an international scale, there is a need to consider different ethical principles, laws, regulations, and policies for data sharing. This article proposes principles and operational considerations for navigating data governance in neuroscience at an international level and highlights the gaps, challenges, and opportunities in the global brain data ecosystem.
Correction
Multidisciplinary Sciences
Bradley S. Gundlach, Michel Frising, Alireza Shahsafi, Gregory Vershbow, Chenghao Wan, Jad Salman, Bas Rokers, Laurent Lessard, Mikhail A. Kats
SCIENTIFIC REPORTS
(2022)
Article
Anatomy & Morphology
S. Vinci-Booher, B. Caron, D. Bullock, K. James, F. Pestilli
Summary: This article investigates the interaction between the ventral and dorsal visual streams and the development of associated white matter tracts. The study suggests that the posterior vertical pathway (PVP) plays a potential role in facilitating interactions between the two streams during learning.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Daniel N. Bullock, Elena A. Hayday, Mark D. Grier, Wei Tang, Franco Pestilli, Sarah R. Heilbronner
Summary: The functional and computational properties of brain areas are largely determined by their connectivity profiles. White matter, as the foundation of long-range anatomical connections, plays a crucial role in studying brain connectivity and anatomy. However, different accounts of white matter tract anatomy hinder our accurate mapping of the connectivity of the human brain. By combining histological tract-tracing and diffusion-weighted tractography studies, we can gain new insights into brain connectivity.
Article
Multidisciplinary Sciences
Hu Cheng, Sophia Vinci-Booher, Jian Wang, Bradley Caron, Qiuting Wen, Sharlene Newman, Franco Pestilli
Summary: This study proposes a simple denoising method using a one-dimensional convolutional neural network (1D-CNN) and deep learning to learn from a low-noise dataset, and applies it to high-noise datasets. The results show that this method produces DWI images that are more similar to noise-free ground truth compared to other methods, and also shows promising results in diffusion metrics and tractography.
Article
Neurosciences
Tyler S. Manning, Benjamin N. Naecker, Iona R. McLean, Bas Rokers, Jonathan W. Pillow, Emily A. Cooper
Summary: In this article, the authors discuss the transformation of sensory inputs into percepts in neuroscience, and how Bayesian ideal observer models can be used to evaluate the integration of prior knowledge and sensory information. They also introduce a novel approach to recover the shape of Bayesian priors using mixtures of Gaussian distributions, providing more flexibility in the analysis.
Article
Computer Science, Interdisciplinary Applications
Varsha Sreenivasan, Sawan Kumar, Franco Pestilli, Partha Talukdar, Devarajan Sridharan
Summary: Different tractography algorithms can produce widely varying connectivity estimates. This study introduces a GPU-based implementation that achieves significantly faster speeds and improved accuracy in generating brain connectomes. The implementation also has potential applications in various real-world problems.
NATURE COMPUTATIONAL SCIENCE
(2022)
Meeting Abstract
Critical Care Medicine
Lauren Wilkins, Giulia Berto, Franco Pestilli, Nicholas Port
JOURNAL OF NEUROTRAUMA
(2022)
Article
Neurosciences
M. Babo-Rebelo, A. Puce, D. Bullock, L. Hugueville, F. Pestilli, C. Adam, K. Lehongre, V Lambrecq, V Dinkelacker, N. George
Summary: This study analyzed intracerebral EEG data from 11 epileptic patients to explore the processing of facial and social cues in the occipitotemporal regions. The findings show that face processing starts in the inferior occipital cortex and progresses to the fusiform and inferior temporal cortices, with the superior temporal sulcus responding preferentially to gaze changes. The study also indicates likely involvement of both dorsal and ventral posterior white matter pathways in the network processing.
Article
Neurosciences
Ryan P. Silk, Hanagh R. Winter, Ouria Dkhissi-Benyahya, Carmella Evans -Molina, Alan W. Stitt, Vijay K. Tiwari, David A. Simpson, Eleni Beli
Summary: This study investigates whether diabetes affects the daily rhythm of gene expression in the retina. The results show that diabetic mice exhibited phase advancement in the expression of certain genes compared to non-diabetic mice. The study also identified oxygen-sensing mechanisms and HIF1alpha as potential upstream regulators. These findings provide important insights into the development of diabetic retinopathy.
Article
Neurosciences
Krishnamachari S. Prahalad, Daniel R. Coates
Summary: Visual stimuli presented around the time of a saccade can be perceived differently by the visual system, including a reduction in the harmful impact of flankers. This study investigated the effects of microsaccades on crowded stimuli placed 20 arc minutes from the center of gaze. The findings suggest two separate pre-saccadic benefits, one that regularizes the crowding zone and another that specifically benefits microsaccade targets surrounded by tangential flankers.
Article
Neurosciences
Chandrika Ravisankar, Christopher W. Tyler, Clifton M. Schor, Shrikant R. Bharadwaj
Summary: This study revealed that less than one-third of adults with normal binocular vision were able to successfully free-fuse random-dot image pairs and identify the embedded stereoscopic shapes. The successful participants showed a dissociation of vergence and accommodative responses, while the unsuccessful ones either exhibited strong vergence and accommodation or weak vergence and strong accommodation. Task performance of the unsuccessful cluster improved significantly with pharmacological paralysis of accommodation. A minority of participants also learned to dissociate one direction of their vergence and accommodation crosslinks with repeated free-fusion trials, optimizing their task performance.
