Article
Gastroenterology & Hepatology
Davide Roccarina, Laura Iogna Prat, Giada Pallini, Marta Guerrero Misas, Elena Buzzetti, Francesca Saffioti, Francesco M. Arico, Anna Mantovani, Evangelia Koutli, Atul Goyale, Matteo Rosselli, Tu Vinh Luong, Massimo Pinzani, Emmanuel A. Tsochatzis
Summary: This study compared liver stiffness measurements between ElastPQ and F-TE in patients with NAFLD, showing excellent correlation between the two techniques, especially for lower LSM. ElastPQ demonstrated similar diagnostic accuracy to F-TE in staging liver fibrosis in patients with available liver histology.
LIVER INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Junfeng Zhou, Yong Long, Ning Ding, Yingjie Su
Summary: This study found a positive association between later bedtime and nonalcoholic fatty liver disease (NAFLD), particularly on weekends. The relationship between bedtime and NAFLD varied across different time periods and different definitions of CAP score.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Gastroenterology & Hepatology
Suzanne R. Sharpton, Nobuharu Tamaki, Ricki Bettencourt, Egbert Madamba, Jinho Jung, Amy Liu, Cynthia Behling, Mark A. Valasek, Rohit Loomba
Summary: In a prospective study including more than 100 adults with NAFLD, VCTE was found to be more accurate than 2D-SWE in detecting fibrosis; however, these modalities are comparable in assessing for higher stages of fibrosis.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Donghee Kim, George Cholankeril, Rohit Loomba, Aijaz Ahmed
Summary: Accurate assessment and estimation of fatty liver disease and hepatic fibrosis are crucial in clinical practice. Studies have shown that the application of transient elastography and controlled attenuation parameter has improved the measurement accuracy of fatty liver disease and hepatic fibrosis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Engineering, Biomedical
K. J. Parker, J. Ormachea
Summary: A framework has been developed to estimate the volume fraction of fat in steatotic livers from viscoelastic measures of shear wave speed and attenuation, which can be widely used for assessing and monitoring steatosis. The framework assumes spherical fat vesicles in the liver and uses a rheological model to determine shear modulus based on increasing fat volume. Accurate measurements of shear wave speed and attenuation provide sufficient information to solve for unknown fat volume and liver stiffness.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Alexander Chaidez, Zhaoxing Pan, Shikha S. Sundaram, Julia Boster, Mark Lovell, Ronald J. Sokol, Cara L. Mack
Summary: Vibration controlled transient elastography (Fibroscan) can be used to predict the severity of liver fibrosis and steatosis. This study investigated the correlation between FibroScan measurements and liver histologic features in pediatric nonalcoholic fatty liver disease (NAFLD). The study also assessed the predictive capacity of the FibroScan-aspartate aminotransferase (FAST) score in pediatric NAFLD.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Ahmad Hassan Ali, Alhareth Al Juboori, Gregory F. Petroski, Alberto A. Diaz-Arias, Majid M. Syed-Abdul, Andrew A. Wheeler, Rama R. Ganga, James B. Pitt, Nicole M. Spencer, Ghassan M. Hammoud, R. Scott Rector, Elizabeth J. Parks, Jamal A. Ibdah
Summary: The diagnostic accuracy of Fibroscan in predicting significant liver fibrosis in morbidly obese patients (BMI>=40 kg/m(2)) is 71.3%. A model incorporating hemoglobin A1c and alkaline phosphatase with liver stiffness measurement improves accuracy in detecting significant fibrosis in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Luis C. Bertot, Gary P. Jeffrey, Bastiaan de Boer, Zhengyi Wang, Yi Huang, George Garas, Gerry MacQuillan, Michael Wallace, Briohny W. Smith, Leon A. Adams
Summary: This study compared the accuracy of different methods for detecting fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). The results showed that the Hepascore method had higher accuracy in diagnosing advanced fibrosis than other simple serum models, and also had higher accuracy in obese individuals compared to Fibroscan (R). Therefore, the Hepascore method is more suitable for diagnosing fibrosis in NAFLD patients compared to other methods.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Clinical Neurology
Linlin Sun, Nan Li, Ligang Zhang, Jingxu Chen
Summary: This study aimed to evaluate the role of Elastography point quantification (ElastPQ) in the quantitative assessment of fatty liver disease in mental disorder patients and provide a noninvasive detection method for non-alcoholic fatty liver (NAFLD) caused by atypical antipsychotics drugs (AAPDs). A total of 168 mental disorder patients treated with AAPDs and 58 healthy volunteers were included in the study. All subjects underwent ultrasound and ElastPQ tests, and the basic data of the patients were analyzed. The results showed that BMI, liver function, and ElastPQ value were significantly higher in the patient group compared to the healthy volunteers. The value of ElastPQ increased with treatment prolongation, and Olanzapine had a considerable influence on liver stiffness.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Review
Oncology
Lucia Cerrito, Irene Mignini, Maria Elena Ainora, Carolina Mosoni, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Hepatocellular carcinoma (HCC) risk is increased in nonalcoholic fatty liver disease (NAFLD), even without cirrhosis. New noninvasive tests have been proposed to predict HCC risk, and imaging techniques evaluating liver stiffness have gained increasing importance in this context.
Article
Medicine, General & Internal
Jon Nielsen, Mette Skalshoi Kjaer, Allan Rasmussen, Deepthi Chiranth, Gro Linno Willemoe, Birthe Merete Henriksen, Lotte Borgwardt, Mia Klinten Grand, Lise Borgwardt, Vibeke Brix Christensen
Summary: USe, TE and MRe have good discriminatory ability for assessing advanced liver fibrosis in pediatric liver disease, with TE and MRe performing best. For most children, TE is a reliable and easily applicable measure.
Article
Pediatrics
Lea Chantal Tran, Delphine Ley, Gurvan Bourdon, Stephanie Coopman, Heloise Lerisson, Celine Tillaux, Helene Behal, Frederic Gottrand, Madeleine Aumar
Summary: This study evaluated the agreement between two-dimensional ultrasound shear wave elastography (2D-SWE) and transient elastography (TE) in assessing liver stiffness in children. The results showed a strong correlation between the measurements obtained by the two techniques, but only a moderate concordance in assessing liver fibrosis stages. Therefore, it is suggested not to alternate between these methods during follow-up of patients with chronic liver diseases.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Chan-Young Jung, Geun Woo Ryu, Hyung Woo Kim, Sang Hoon Ahn, Seung Up Kim, Beom Seok Kim
Summary: The study showed a significant association between advanced liver fibrosis measured by transient elastography (TE) and an increased risk of incident chronic kidney disease (CKD) in individuals with non-alcoholic fatty liver disease (NAFLD) who do not have baseline CKD.
Review
Gastroenterology & Hepatology
Elton Dajti, Federico Ravaioli, Romanas Zykus, Pierre-Emmanuel Rautou, Laure Elkrief, Ivica Grgurevic, Horia Stefanescu, Masashi Hirooka, Mirella Fraquelli, Matteo Rosselli, Pik Eu Jason Chang, Fabio Piscaglia, Thomas Reiberger, Elba Llop, Sebastian Mueller, Giovanni Marasco, Annalisa Berzigotti, Agostino Colli, Davide Festi, Antonio Colecchia
Summary: The combination of spleen stiffness measurement (SSM) with the Baveno VII criteria improves the accuracy of diagnosing clinically significant portal hypertension and reduces the diagnostic grey zone.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Dimitrios S. Karagiannakis, George Markakis, Dimitra Lakiotaki, Evangelos Cholongitas, Jiannis Vlachogiannakos, George Papatheodoridis
Summary: This study evaluated the performance of 2D-shear wave elastography (2D-SWE) and transient elastography in patients with nonalcoholic fatty liver disease (NAFLD) and found that both methods are feasible and clinically applicable for diagnosing fibrosis and cirrhosis in NAFLD patients.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amna Al-Jabri, Jennie Cooke, Sean Cournane, Marie-Louise Healy
Summary: The study found a stronger correlation between Tc-99m and I-131 data in male patients, with female patients being influenced by age and time difference in uptake measurements. Both genders showed significant correlations in thyroid diagnosis and hormone levels with uptake. Estimating I-131 based on Tc-99m was predictive for males but not for females, indicating the need for further research with larger sample sizes.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, General & Internal
Richard Conway, Declan Byrne, Sean Cournane, Deirdre O'Riordan, Seamus Coveney, Bernard Silke
Summary: The aim of the study was to investigate whether excessive high-sensitivity cardiac troponin T testing in non-cardiac presentations increases hospital length of stay by driving down-stream investigations. The study found that hscTnT testing frequency was higher in elderly patients, those with cardiovascular presentations, and with high comorbidity, but lower in those with neurologic presentations. The study concluded that hscTnT testing is prognostic and risk categorizes, and subsequent resource utilization, if increased, appears related to risk categorization rather than being driven by inappropriate testing.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Sport Sciences
Kevin Cronin, Eamonn Delahunt, Shane Foley, Giuseppe De Vito, Conor McCarthy, Sean Cournane
Summary: The study aims to evaluate the influence of hamstring muscle architectural characteristics on injury risk by developing and assessing a novel semi-automated tracing software for precise measurement of the biceps femoris long head in B-mode ultrasound images.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Environmental Sciences
Ann McCann, Luis Leon Vintro, Sean Cournane, Julie Lucey
Summary: This study investigated occupational exposure of personnel manipulating PET radiopharmaceuticals, and evaluated radiation doses to extremities from different radioisotopes in unshielded and shielded syringes. Results showed that contact skin dose rates for most isotopes were similar, except for Zr-89 which had significantly higher dose rates.
JOURNAL OF RADIOLOGICAL PROTECTION
(2021)
Article
Optics
J. O'Callaghan, S. Cournane, J. McCavana, D. Cody
Summary: This paper presents a novel configuration for a D-PDT dose sensor that can be placed adjacent to the treatment site to accurately quantify the light dose received. The theoretical modeling and experimental results show that the initial absorption and grating thickness have a significant impact on the magnitude and rate of the sensor response.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
J. E. Browne, L. M. Cannon, A. J. Fagan, S. Cournane
Summary: The study aims to develop contrast-detail and anechoic-target phantoms for performance testing of breast ultrasound equipment. The results indicate the importance of using appropriate targets in ultrasound phantoms and the comprehensive assessment provided by the spherical lesion phantoms coupled with the quantitative metric of lesion-signal-noise-ratio (LSNR) for evaluating advanced ultrasound imaging modes and technologies.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Environmental Sciences
Sean Cournane, Matthew Reade, Jackie McCavana, Julie Lucey
Summary: This study examined the impact of increased localiser region of interest in a hybrid PET/CT on CTDIvol, focusing on extraneous objects and patient attenuation profiles.
RADIATION PROTECTION DOSIMETRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Jane Doyle, Dervil Cody, Deirdre M. King, Prof Francis J. Sullivan, Jacinta E. Browne
Summary: This study introduced a simulation-based transrectal ultrasound (TRUS) imaging training workshop for medical physicists involved in low-dose-rate (LDR) prostate brachytherapy (PBT). Results demonstrated significant improvement in knowledge and skills related to TRUS imaging, indicating the potential benefits of simulation training for healthcare professionals involved in prostate brachytherapy.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Acoustics
Andrea Jane Doyle, Dervil Cody, Silvin Knight, Deirdre M. King, Francis J. Sullivan, Jacinta E. Browne
Summary: Ultrasound-guided prostate brachytherapy is an effective treatment option, but it requires an optimized transrectal ultrasound (TRUS) system. This study developed task-specific contrast-detail phantoms and an objective assessment procedure to evaluate the contrast detectability of TRUS systems used in brachytherapy. The results showed the efficacy of the device as an image quality evaluation tool and the impact of target characteristics on TRUS system's contrast detectability.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Niamh McArdle, Sean Cournane, Jackie McCavana, Julie Lucey, Luis Leon Vintro
Summary: The study corrected for scatter effects in LSF estimation using Monte Carlo simulation software, resulting in improved accuracy and reduced overestimation. Scatter window corrections were effective in reducing uncertainty and improving LSF estimation within a range of known values.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Oncology
Cora Marshall, Pierre Thirion, Alina Mihai, John G. Armstrong, Sean Cournane, Darina Hickey, Brendan McClean, John Quinn
Summary: The study aimed to evaluate the interobserver variability in contouring GTV for colorectal liver metastases using MRI and CT in the setting of SABR. The results showed that MR LAVA exhibited the lowest interobserver variability, indicating the benefit of using MR to complement CT in GTV contouring for colorectal liver metastases.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Kevin Cronin, Shane Foley, Sean Cournane, Giuseppe De Vito, Eamonn Delahunt
Summary: The intra-rater reliability of static wide field of view ultrasound in quantifying the architectural characteristics of the hamstring muscles in male amateur athletes was assessed. The results showed that the architectural characteristics can be reliably quantified using static wide field of view ultrasound.
Article
Medicine, General & Internal
Andrew J. Malone, Sean Cournane, Izabela Naydenova, James F. Meaney, Andrew J. Fagan, Jacinta E. Browne
Summary: Cardiovascular pathology is a major cause of death and disability in the Western world. Traditional diagnostic testing evaluates the anatomy of the vessel for blockages and plaques, but there is a belief that measuring wall shear stress provides more useful information for early diagnosis and prediction of atherosclerotic disease. A new algorithm called Multifrequency ultrafast Doppler spectral analysis (MFUDSA) was developed to quantify wall shear stress in atherosclerotic plaque using diagnostic ultrasound imaging. The algorithm outperformed other commonly used assessment methods and has the potential to provide earlier diagnosis of cardiovascular disease than current techniques.
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian J. Burkett, Chad M. Rasmussen, W. Jonathan Fillmore, Jennifer S. Mcdonald, Robert J. Mcdonald, Andrew J. Fagan, Sarah A. Erdahl, Steven J. Eckdahl, Kirk M. Welker
Summary: The study found that MRI does not significantly increase mercury excretion from dental amalgam at 1.5T, 3T, or 7T field strengths, both for laboratory restorations and for those placed and lived with prior to extraction and scanning, demonstrating no added risk to the clinical patient or research subject.
MAGNETIC RESONANCE IN MEDICINE
(2023)