Article
Chemistry, Physical
Hala I. El-Naggar, E. H. Ghanim, M. El Ghazaly, T. T. Salama
Summary: The study investigates the modification of the self-developed GafChromic EBT2 radiochromic film for registering 2 MeV alpha particles. The results show that the darkness of the irradiated EBT2-M film increases with exposure time but saturates at prolonged exposure, and the absorbance spectra correlate with the exposure time to 2 MeV alpha particles. The study demonstrates the potential use of the modified EBT2-M radiochromic film for mapping the relative dose delivered by low-energy alpha particles.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kevin Liu, Patrik Goncalves Jorge, Ramesh Tailor, Raphael Moeckli, Emil Schuler
Summary: This study evaluated the performance of Gafchromic EBT3 film under various measurement conditions to simplify but enhance film dosimetry. The results showed that scanning the film within a certain time window and using a standard calibration curve introduced a maximum error of 2% over a dose range of 1-40 Gy. The film response was influenced by the film-read delay, film batch, scanner type, and beam energy.
Article
Chemistry, Physical
I. Mendez, B. Casar
Summary: This study analyzed the advantages and disadvantages of using superellipses to describe field sizes, finding that small fields can be characterized more accurately with superellipses. Field output factors can be derived using equivalent square small-field sizes based on the superellipse approach.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Mattias Klaus Juhl, Binesh Puthen Veettil, Giuseppe Scardera, David Neil Roger Payne
Summary: This paper investigates the use of consumer flatbed scanners for monitoring solar cell precursors, finding that contact image sensors are more suitable. The scanners' ability to monitor texture variation in samples was successfully demonstrated.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Antony L. Palmer, David Nash, Wojciech Polak, Sarah Wilby
Summary: This study evaluated the differences between the new Gafchromic EBT4 film and the current EBT3 film for radiotherapy dosimetry. The results showed that EBT4 had more favorable characteristics for radiation dosimetry compared to EBT3, with improved signal-to-noise ratio. EBT4 provided better agreement with the planned doses and showed equivalent or smaller difference in measured dose compared to EBT3.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Connor Mcnairn, Iymad Mansour, Bryan Muir, Rowan M. Thomson, Sangeeta Murugkar
Summary: This work aims to develop a new approach for high spatial resolution dosimetry using Raman micro-spectroscopy scanning of radiochromic film. The study achieved high resolution in dose response of the film, down to 0.03 Gy, and generated calibration curves for dose estimation. The total uncertainty in dose estimation ranged from [6-9]% for doses between 0.5-50 Gy, with experimental uncertainty contributing [5-8]%, and fitting uncertainty contributing [2.5-4.5]%.
Article
Chemistry, Physical
Magdalena Maria Skowyra, Christina Ankjaergaard, Liyun Yu, Lars Rene Lindvold, Anne Ladegaard Skov, Arne Miller
Summary: The commercially used Riso B3 radiochromic film dosimeter can achieve full-color development and stability of measured absorbance through a post-irradiation heat treatment procedure. However, the choice of heating duration and temperature is based on trial and error. Research shows that the B3 film undergoes rapid thermal decomposition at high temperatures, and the post-irradiation heating temperature matches the polymer material's glass transition temperature.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Engineering, Biomedical
Aleksi Saikkonen, Jarkko Ojala, Petri Sipila, Eeva Boman, Jani Keyrilaeinen
Summary: The objective of this study was to investigate the feasibility and accuracy of dose delivered from a high-dose-rate (HDR) afterloaders in keloid scar brachytherapy using Monte Carlo (MC) simulations and measurements. The treatment doses and central axis dose profiles were measured using dosimeters and films, and the results showed that the measured and simulated dose profiles matched well, indicating the possibility of achieving the nominal treatment dose with the utilized setup.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Review
Chemistry, Physical
Tania Santos, Tiago Ventura, Maria do Carmo Lopes
Summary: The dosimetry system composed of Gafchromic (TM) EBT films and a flatbed document scanner is valuable for patient-specific quality assurance of complex external beam radiotherapy treatment plans. However, lack of comprehensive performance characterization and establishment of complex dosimetry protocols may be reasons for its limited adoption in clinical practice. This work aims to provide guidance on establishing a reliable film dosimetry system for dose verification in external photon beam radiotherapy, reviewing practical aspects and critically discussing advantages and limitations of different approaches.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Oncology
Ignasi Mendez, Juan Jose Rovira-Escutia, Bozidar Casar
Summary: This study presents an effective protocol for accurate radiochromic film dosimetry using Radiochromic.com software, providing precise dose results by reducing sources of uncertainty. Proper film and scanner handling procedures combined with Radiochromic.com software make easy and accurate radiochromic film dosimetry feasible.
RADIOLOGY AND ONCOLOGY
(2021)
Article
Engineering, Biomedical
Marchant Van der Walt, Linda Marsh, John Baines, Stephen Gibson, Ariadne Shoobridge, Glenn de Vine
Summary: This study investigates the performance of an LED flatbed scanner in a clinical radiochromic film dosimetry program. The results show that the lateral response variation needs correction, while the longitudinal response variation can be ignored. The scanner exhibits good linear scaling and reproducibility, and is no longer dependent on warm up time. Additionally, the lateral response correction is dose independent and has evidence of film type independence.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
James Renaud, Bryan Muir
Summary: The aim of this study is to reduce the uncertainty associated with determining dose-to-water using an amorphous silicon electronic portal imaging detector (EPID) under reference conditions. The results show that the proposed direct calibration method provides accurate measurements of dose-to-water.
Article
Chemistry, Inorganic & Nuclear
Bhaskar Mukherjee, Uday Bhonsle
Summary: This paper introduces a novel evaluation method for radiochromic films, using cosine-distance analysis of RGB-color vectors instead of conventional optical density measurements, which extends the detection limit to over 40 Gy.
APPLIED RADIATION AND ISOTOPES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicole I. C. Cappelletto, Martin G. Shim
Summary: This study investigated the feasibility of using radiochromic film (RCF) dosimetry for vertical dose profile measurements in Total Skin Electron Therapy (TSET) and established a novel RCF based quality assurance protocol. The results showed that RCF dosimetry provided accurate and efficient measurement of vertical dose profiles compared to ionization chambers (ICs), which are currently the gold standard.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul Retif, Abdourahamane Djibo Sidikou, Romain Letellier, Emilie Verrecchia-Ramos, Philippe Quetin
Summary: This study evaluated the QA performance of a novel phantom for lung SBRT treatment, showing that the measured and planned dose distributions were very similar, supporting the current understanding that dose calculations on AIP image sets adequately account for tumor motion during treatment. The phantom also demonstrated good performance despite challenging breathing parameters and the use of a complex treatment technique, suggesting its potential for facilitating clinical dosimetric QA for lung SBRT.
Article
Engineering, Biomedical
Behzad Rezaeifar, Cecile J. A. Wolfs, Natasja G. Lieuwes, Rianne Biemans, Brigitte Reniers, Ludwig J. Dubois, Frank Verhaegen
Summary: This study introduces a framework for using a deep convolutional neural network to predict the center of mass of glioblastoma tumors based on bioluminescence imaging. The predicted center of mass is then used to estimate a planning target volume, and the results show sub-millimeter accuracy for the prediction. The proposed method also demonstrates promising performance for tumor targeting while minimizing radiation exposure to healthy tissues.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vanessa Da Silva Mendes, Michael Reiner, Lili Huang, Daniel Reitz, Katrin Straub, Stefanie Corradini, Maximilian Niyazi, Claus Belka, Christopher Kurz, Guillaume Landry, Philipp Freislederer
Summary: This study evaluated the accuracy and workflow of the EXTD image guidance system in radiotherapy and compared it to CBCT. The results showed that the EXTD system provides accurate image guidance at any couch angle, with comparable accuracy to other IGRT systems.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria Kawula, Indrawati Hadi, Lukas Nierer, Marica Vagni, Davide Cusumano, Luca Boldrini, Lorenzo Placidi, Stefanie Corradini, Claus Belka, Guillaume Landry, Christopher Kurz
Summary: The aim of this study was to train convolutional neural networks (CNNs) for automatic segmentation of bladder, rectum (organs at risk, OARs), and clinical target volume (CTV) for prostate cancer patients treated at 0.35 T MR-Linacs. The results showed that the presented segmentation technique has the potential to improve automatic segmentation for MR-guided RT.
Article
Engineering, Biomedical
Sebastian Tattenberg, Raanan Marants, Katharina Niepel, Thomas Bortfeld, Atchar Sudhyadhom, Guillaume Landry, Katia Parodi, Joost Verburg
Summary: We validated the performance of our prompt gamma-ray spectroscopy detector prototype for proton range verification using tissue-mimicking and porcine samples. The measured proton ranges and elemental sample compositions were in good agreement with the ground truth. These findings confirm the reliability of the system for a variety of tissues and bridge the gap between previously-reported experiments and ongoing in vivo patient measurements.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Julie Lascaud, Pratik Dash, Katrin Schnuerle, Jonathan Bortfeldt, Katharina Niepel, Jessica Maas, Matthias Wuerl, Marie Vidal, Joel Herault, Guillaume Landry, Alessandro Stuart Savoia, Kirsten Lauber, Katia Parodi
Summary: This study presents a multimodal small animal phantom that can be used for various imaging modalities, including proton therapy and ionoacoustics. The anatomical parts of the phantom are visible in all imaging modalities, and the co-registration between ultrasound and X-ray imaging confirms the irradiation of a simulated tumor.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Yuqing Xiong, Moritz Rabe, Lukas Nierer, Maria Kawula, Stefanie Corradini, Claus Belka, Marco Riboldi, Guillaume Landry, Christopher Kurz
Summary: This study evaluated the impact of prostate motion during gated MRI-guided online adaptive radiotherapy for prostate cancer. The results showed that the benefit of the gating was negligible for most patients, and the clinical dosimetric constraints were met, indicating safety of the currently adopted treatment workflow.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Teun van Wagenberg, Gabriel Paiva Fonseca, Robert Voncken, Celine van Beveren, Evert van Limbergen, Ludy Lutgens, Ben G. L. Vanneste, Maaike Berbee, Brigitte Reniers, Frank Verhaegen
Summary: In this study, a heterogeneous head phantom was used to test an imaging panel (IP) approach for treatment verification and error detection. The results showed that the IP could accurately measure dwell times and positions, and detect simulated treatment errors.
Review
Engineering, Biomedical
Frank Verhaegen, Karl T. Butterworth, Anthony J. Chalmers, Rob P. Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D. Fenwick, Patrick Granton, Stefan H. J. Heijmans, Mark A. Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C. G. G. Persoon, Nick Staut, Anna Subiel, Rianne D. W. Vaes, Stefan van Hoof, Ioannis L. Verginadis, Jan J. Wilkens, Kaye J. Williams, George D. Wilson, Ludwig J. Dubois
Summary: This paper provides an overview of precision preclinical x-ray radiation studies in animal models. It focuses on cancer and normal tissue response to radiation, but also addresses other disease models. The advancements in imaging, irradiation, dosimetry, and monitoring are discussed, along with future developments. The paper also explores clinical translation and reverse translation.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Y. Chan, M. Li, K. Parodi, C. Belka, G. Landry, C. Kurz
Summary: This study investigates the feasibility of using low dose CBCT imaging to accurately calculate prostate radiotherapy dose, by employing cycleGAN to correct under-sampling artifacts and CT numbers. The results show that CBCTLD_ResGAN performs better in terms of anatomical fidelity.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Behzad Rezaeifar, Cecile J. A. Wolfs, Natasja G. Lieuwes, Rianne Biemans, Brigitte Reniers, Ludwig J. Dubois, Frank Verhaegen
Summary: In this study, a novel solution is proposed for accurate 3D bioluminescence tomography (BLT) based glioblastoma (GBM) targeting. The solution utilizes a deep-learning approach to enable BLT-based tumor targeting and treatment planning for orthotopic rat GBM models. The results show that the deep learning model achieves high accuracy in tumor localization and treatment planning.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Esther Kneepkens, Cecile Wolfs, Roel-Germ Wanders, Erik Traneus, Danielle Eekers, Frank Verhaegen
Summary: The study tested the effects of shoot-through FLASH proton beams on dose-averaged LET (LETD) values and proton range in critical organs, and found that shoot-through plans have lower LETD values and better stability.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Cecile J. A. Wolfs, Frank Verhaegen
Summary: The choice of dose comparison method has the greatest impact on error identification using DL for pre-treatment QA. Simple dose comparison methods yield the highest accuracy, while mean/stdev normalization and high image resolution can improve model performance in error identification.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
M. Kawula, I. Hadi, L. Nierer, M. Vagni, D. Cusumano, L. Boldrini, L. Placidi, S. Corradini, C. Belka, G. Landry, C. Kurz
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Y. Chan, M. Li, K. Parodi, C. Belka, G. Landry, C. Kurz
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
G. Dedes, H. Drosten, S. Goetz, J. Dickmann, C. Sarosiek, M. Pankuch, N. Krah, S. Rit, V. Bashkirov, R. Schulte, R. Johnson, K. Parodi, E. DeJongh, G. Landry
