4.6 Article

Characterization of a high-purity germanium detector for small-animal SPECT

Journal

PHYSICS IN MEDICINE AND BIOLOGY
Volume 56, Issue 18, Pages 5877-5888

Publisher

IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/56/18/007

Keywords

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Funding

  1. Office of Science (BER), US Department of Energy [DE-SC0002437]
  2. NIH/National Center for Research Resources [R44RR031937]
  3. NIH/National Cancer Institute [R25CA136440]

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We present an initial evaluation of a mechanically cooled, high-purity germanium double-sided strip detector as a potential gamma camera for small-animal SPECT. It is 90 mm in diameter and 10 mm thick with two sets of 16 orthogonal strips that have a 4.5 mm width with a 5 mm pitch. We found an energy resolution of 0.96% at 140 keV, an intrinsic efficiency of 43.3% at 122 keV and a FWHM spatial resolution of approximately 1.5 mm. We demonstrated depth-of-interaction estimation capability through comparison of pinhole acquisitions with a point source on and off axes. Finally, a flood-corrected flood image exhibited a strip-level uniformity of less than 1%. This high-purity germanium offers many desirable properties for small-animal SPECT.

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