Review
Radiology, Nuclear Medicine & Medical Imaging
Celestine Angla, Benoit Larrat, Jean-Luc Gennisson, Sylvain Chatillon
Summary: Transcranial ultrasound is increasingly utilized in brain therapy and imaging. However, the skull presents challenges as it attenuates and distorts ultrasound waves, and its structure and acoustic properties vary across samples and even within the same sample. To ensure safe transcranial focused ultrasound interventions, case-specific simulations are necessary. In this article, we review the different methods used to model the skull and simulate ultrasound propagation through it.
Article
Acoustics
Thomas S. Riis, Taylor D. Webb, Jan Kubanek
Summary: The study characterized the impact of different anatomical segments of the skull on transcranial ultrasound propagation. Parietal bone showed higher transmission and smaller phase distortion compared to frontal and occipital bone regions. Across skull regions, transmission was strongly anti-correlated with skull thickness, while phase distortion was correlated with it.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengyue Chen, Chang Peng, Huaiyu Wu, Chih-Chung Huang, Taewon Kim, Zachary Traylor, Marie Muller, Pratik Y. Chhatbar, Chang S. Nam, Wuwei Feng, Xiaoning Jiang
Summary: This study investigated the wave propagation of low-intensity transcranial focused ultrasound (tFUS) on human skulls using experimental measurements and numerical modeling. The results showed that ultrasound frequency and FUS transducer aperture size significantly affected transmission efficiency and beamwidth. These findings have important implications for clinical applications of ultrasound neuromodulation and the development of advanced ultrasound transducers as neural interfaces.
Article
Medicine, Research & Experimental
Evan J. Patel, Nicholas L. Deep, Michael Schecht, Mari Hagiwara, John T. Roland
Summary: This retrospective case series characterized patients with MRI evidence of spontaneous vestibular schwannoma regression. Patients were divided into major regression (>40% volume decrease) and minor regression (<40% volume reduction) cohorts, with no significant differences observed in initial tumor size, rate of regression, or audiometric changes between the two groups.
Article
Thermodynamics
Qi Zhang, Yanfei Wang
Summary: For unconfined natural gas hydrate deposits in the Shenhu area, in-situ electrical heating methods, such as wellbore and low-frequency electrical heating (WBEH, LFEH), are proposed to assist depressurization for promoting gas production. Through numerical simulations, three LFEH-assisted depressurization schemes are compared with only depressurization (OD) and WBEH to determine the optimal exploitation method. The results show that LFEH significantly promotes hydrate dissociation and gas production, while the brine flooding scheme recovers more gas and net energy over OD.
Article
Engineering, Multidisciplinary
Rafal Bielas, Bassam Jameel, Arkadiusz Jozefczak
Summary: Magnetic heating of colloidal systems is a common method for inducing temperature rise, and ultrasound was used in this study to investigate the effects of alternating magnetic fields on the structure of magnetic colloids, which may impact the stability of magnetic dispersions or magnetic Pickering emulsions.
Article
Acoustics
Soline Bernard, Maxime Bilodeau, Patrice Masson, Francois Moreau, Jean-Francois Lepage, Philippe Micheau, Nicolas Quaegebeur
Summary: Optimization and validation of transcranial ultrasound methods require the use of fresh human or animal skulls, but fixation methods are needed to prevent degradation over time. Plastination offers a unique solution for preservation and transportation without constraints, but its influence on ultrasound transmission needs to be studied. This study quantified the effect of plastination on ultrasound transmission through human skull, finding a 5 dB transmission loss but no phase shift in the transmitted signal.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Acoustics
Collin S. Smith, Christopher O'Driscoll, Emad S. Ebbini
Summary: Transcranial focused ultrasound (tFUS) is a promising approach for treating neurological disorders. It has been shown to be effective in various clinical applications and has promising outcomes. The key to optimizing the safety and efficacy of tFUS treatment through the temporal window is using modern array transducers and driving systems to intelligently target specific regions of the brain. This study investigates the ultrasound reflection and transmission characteristics of different access points within the temporal window of human skull samples, demonstrating the feasibility of this approach.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Oncology
Kenichiro Iwami, Tadashi Watanabe, Koji Osuka, Tetsuya Ogawa, Shigeru Miyachi, Yasushi Fujimoto
Summary: The study demonstrated the feasibility of the combined exoscopic-endoscopic technique as an alternative to the microscope in craniofacial resection (CFR). The exoscope and endoscope offered advantages such as compact size, ergonomics, and equal visual experience for surgeons, enabling simultaneous transcranial and transfacial surgical procedures.
Article
Chemistry, Multidisciplinary
Xuandi Hou, Zhihai Qiu, Quanxiang Xian, Shashwati Kala, Jianing Jing, Kin Fung Wong, Jiejun Zhu, Jinghui Guo, Ting Zhu, Minyi Yang, Lei Sun
Summary: Ultrasound can be used non-invasively for neuromodulation, with the potential to improve spatial resolution and increase effectiveness. A neurostimulation scheme using gas vesicles as actuators showed enhanced and targeted effects without significant cytotoxicity, demonstrating a promising method for improved neurostimulation.
Review
Oncology
Othman Bin-Alamer, Lokeshwar S. Bhenderu, Paolo Palmisciano, Kishore Balasubramanian, Prashant Upadhyay, Gianluca Ferini, Anna Viola, Valentina Zagardo, Kenny Yu, Aaron A. Cohen-Gadol, Tarek Y. El Ahmadieh, Ali S. Haider
Summary: The infratemporal fossa (ITF) is a rare site for tumors and this study aims to review the literature on the various tumors that occur in this region, their treatment strategies and patient outcomes.
Article
Oncology
Katherine E. Baker, Austin C. Robbins, Zeynep T. Kumm, Michael K. Ziemke, Chad W. Washington, Gustavo D. Luzardo, Charlotte S. Taylor, Scott P. Stringer, Marcus A. Zachariah
Summary: Clival chordomas are locally invasive midline skull base tumors arising from remnants of the primitive notochord. Several intraoperative image guidance modalities have been introduced as adjuncts to endoscopic endonasal surgery, including stereotactic neuronavigation, intraoperative ultrasound, intraoperative MRI, and intraoperative CT. In this case report, we discuss the benefits of employing a novel minimally invasive side-firing ultrasound probe as a cost-effective and time-efficient option to navigate the anatomy of the paraclival region and guide endoscopic endonasal resection of a large complex clival chordoma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Katherine E. Baker, Austin C. Robbins, Robert G. Wasson, Martin G. McCandless, Seth T. Lirette, Rebekah J. Kimball, Chad W. Washington, Gustavo D. Luzardo, Scott P. Stringer, Marcus A. Zachariah
Summary: Incorporating side-firing intraoperative ultrasound (IOUS) as an aid in endonasal resection of pituitary adenomas can provide real-time image guidance, increase surgeon confidence, reduce operative time, and potentially decrease the occurrence of postoperative diabetes insipidus.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Davis G. Taylor, Ajay Chatrath, Panagiotis Mastorakos, Gabriella Paisan, Ching-Jen Chen, Thomas J. Buell, John A. Jane
Summary: Syringogenesis in CM-I patients is associated with decreased subarachnoid CSF spaces at the cranial outlet. Successful resolution of syrinx post-surgery correlates with increased subarachnoid space expansion.
JOURNAL OF NEUROSURGERY
(2021)
Article
Acoustics
Bowen Jing, Brooks D. Lindsey
Summary: Contrast-enhanced ultrasound imaging can be used for vascular imaging in various diseases. The proposed radial modulation imaging strategy using a very low frequency ultrasound modulation wave combined with imaging pulses provides high-sensitivity contrast-enhanced ultrasound imaging at high penetration depths. The technique suppresses tissue background and improves contrast-to-tissue ratios. It demonstrates successful modulation of microbubble response at 100 kHz and represents the first demonstration of real-time, high-penetration-depth radial modulation imaging for contrast-enhanced ultrasound imaging.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Acoustics
Eero Koponen, Jarkko Leskinen, Tanja Tarvainen, Aki Pulkkinen
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2019)
Article
Computer Science, Interdisciplinary Applications
Teemu Sahlstrom, Aki Pulkkinen, Jenni Tick, Jarkko Leskinen, Tanja Tarvainen
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Optics
Niko Hanninen, Aki Pulkkinen, Aleksi Leino, Tanja Tarvainen
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2020)
Article
Computer Science, Interdisciplinary Applications
Aleksi A. Leino, Tuomas Lunttila, Meghdoot Mozumder, Aki Pulkkinen, Tanja Tarvainen
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Acoustics
Teemu Sahlstrom, Aki Pulkkinen, Jarkko Leskinen, Tanja Tarvainen
Summary: A transformation-based approach is proposed for efficient modeling of photoacoustic signals and reconstruction of images, achieving significantly reduced computational cost in memory and time without compromising image quality. The method is evaluated using numerical simulations and experimental data, demonstrating accurate 3-D photoacoustic image reconstruction.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Optics
Eero Koponen, Jarkko Leskinen, Tanja Tarvainen, Aki Pulkkinen
Summary: Background-oriented schlieren imaging is a method proposed for measuring projections of ultrasound fields. It utilizes the deflection of light in a refractive index field induced by ultrasound to estimate the ultrasound field. The study introduces a nonlinear regularized least-squares approach that outperforms linear methods in estimating medically relevant ultrasound field projections.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2022)
Article
Biochemical Research Methods
Niko Hanninen, Aki Pulkkinen, Simon Arridge, Tanja Tarvainen
Summary: This study developed an adaptive image reconstruction method for quantitative photoacoustic tomography (QPAT) using a combination of the Monte Carlo method for light transport and the adaptive stochastic Gauss-Newton (A-SGN) algorithm. Numerical simulations showed that the proposed method significantly reduced the number of photon packets required for solving the inverse problem compared to conventional approaches, while providing accurate and computationally efficient solutions.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Acoustics
Jean-Francois Aubry, Oscar Bates, Christian Boehm, Kim Butts Pauly, Douglas Christensen, Carlos Cueto, Pierre Gelat, Lluis Guasch, Jiri Jaros, Yun Jing, Rebecca Jones, Ningrui Li, Patrick Marty, Hazael Montanaro, Esra Neufeld, Samuel Pichardo, Gianmarco Pinton, Aki Pulkkinen, Antonio Stanziola, Axel Thielscher, Bradley Treeby, Elwin van 't Wout
Summary: Computational models of acoustic wave propagation are commonly used in transcranial ultrasound therapy. To facilitate intercomparison between different modeling tools and techniques, an international working group formulated a set of numerical benchmarks. The results showed good agreement among the models, particularly in terms of the acoustic focus within the skull. The benchmark definitions, model results, and intercomparison codes are freely available for further comparisons.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Proceedings Paper
Acoustics
Niko Hanninen, Aki Pulkkinen, Aleksi Leino, Tanja Tarvainen
Summary: This study tackles the inverse problem of quantitative photoacoustic tomography in a Bayesian framework, compensating modeling errors caused by an approximate light transport model using Bayesian approximation error modeling.
OPTO-ACOUSTIC METHODS AND APPLICATIONS IN BIOPHOTONICS V
(2021)
Proceedings Paper
Acoustics
Aki Pulkkinen, Aleksi Leino, Tuomas Lunttila, Meghdoot Mozumder, Tanja Tarvainen
Summary: In this work, perturbation Monte Carlo is extended to solve the inverse problem of quantitative photoacoustic tomography, showcasing its feasibility in estimating optical absorption and scattering distributions.
OPTO-ACOUSTIC METHODS AND APPLICATIONS IN BIOPHOTONICS V
(2021)
Proceedings Paper
Acoustics
Teemu Sahlstrom, Aki Pulkkinen, Jarkko Leskinen, Tanja Tarvainen
Summary: This work presents a computationally efficient forward model for photoacoustic tomography that can produce accurate images with significantly reduced computational cost.
OPTO-ACOUSTIC METHODS AND APPLICATIONS IN BIOPHOTONICS V
(2021)
Proceedings Paper
Optics
Teemu Sahlstrom, Aki Pulkkinen, Jenni Tick, Jarkko Leskinen, Tanja Tarvainen
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2020
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jenni Tick, Aki Pulkkinen, Tanja Tarvainen
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2020)
Proceedings Paper
Engineering, Biomedical
Jarkko Leskinen, Aki Pulkkinen, Jenni Tick, Tanja Tarvainen
OPTO-ACOUSTIC METHODS AND APPLICATIONS IN BIOPHOTONICS IV
(2019)
Article
Optics
Aleksi A. Leino, Aki Pulkkinen, Tanja Tarvainen