Article
Multidisciplinary Sciences
Zhifang Wu, Binwei Guo, Bin Huang, Xinzhong Hao, Ping Wu, Bin Zhao, Zhixing Qin, Jun Xie, Sijin Li
Summary: The Q.Clear reconstruction algorithm showed higher RC and CR values, significantly improving quantification accuracy compared to other methods (P<0.05), except for the RC of the 37 mm sphere (P>0.05). The SUVs of sub-centimeter FDG-avid pulmonary nodules reconstructed with Q.Clear had highly significant differences compared to other algorithms (P<0.001). Even after PVC, significant differences (P<0.001) remained in the SUVmean measured by Q.Clear compared to other algorithms.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Palak Wadhwa, Kris Thielemans, Nikos Efthimiou, Kristen Wangerin, Nicholas Keat, Elise Emond, Timothy Deller, Ottavia Bertolli, Daniel Deidda, Gaspar Delso, Michel Tohme, Floris Jansen, Roger N. Gunn, William Hallett, Charalampos Tsoumpas
Summary: This research demonstrates successful computational and physical modelling of the PET-MR system for image acquisition, generating images comparable to those from the manufacturer; the new software developments will be integrated into STIR, providing researchers worldwide with opportunities to establish and expand their image reconstruction methods; by modelling all effects within the system matrix, PET images showing the metabolic uptake of administered radiopharmaceuticals were reconstructed accurately.
Article
Engineering, Biomedical
C. M. Pommranz, F. P. Schmidt, J. G. Mannheim, S. J. Diebold, C. Tenzer, A. Santangelo, B. J. Pichler
Summary: In this study, three different breast PET insert geometries were proposed to be integrated into an existing MRI breast coil in order to enhance the sensitivity and spatial resolution of breast imaging. Monte Carlo simulations were performed to compare the performance characteristics of these geometries. The results showed that Geometry A had the highest sensitivity and best spatial resolution.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Raymond R. Raylman, Alexander Stolin, Savannah Hays, Evan Johnson, Sarah Lankas, Mahder Mekonnen, Kathryn Roemer
Summary: This study investigated the PET-based lesion detection capabilities of a BPET/CT scanner developed by the Department of Radiology Instrumentation group at West Virginia University. The results showed that the system can detect lesions with a diameter of at least 3 mm, and has good to excellent likelihood of detection for different target-to-background ratios.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ian Alberts, George Prenosil, Clemens Mingels, Karl Peter Bohn, Marco Viscione, Hasan Sari, Axel Rominger, Ali Afshar-Oromieh
Summary: Late imaging with a LAFOV PET/CT system can improve tumor-to-background ratio and signal-to-noise ratio of Gallium-68 PSMA-11 images, with only modest impairment in subjective visual imaging quality.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Engineering, Biomedical
Edwin K. Leung, Eric Berg, Negar Omidvari, Benjamin A. Spencer, Elizabeth Li, Yasser G. Abdelhafez, Jeffrey P. Schmall, Weiping Liu, Liuchun He, Songsong Tang, Yilin Liu, Yun Dong, Terry Jones, Simon R. Cherry, Ramsey D. Badawi
Summary: The emergence of long axial field-of-view PET systems provides new opportunities for PET imaging, but also presents challenges for accurate quantification, particularly in cases with constraints from image reconstruction, low count conditions, and large and rapidly changing radioactivity distribution.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kazunari Ishii, Kohei Hanaoka, Shota Watanabe, Daisuke Morimoto-Ishikawa, Takahiro Yamada, Hayato Kaida, Yoshiyuki Yamakawa, Suzuka Minagawa, Shiho Takenouchi, Atsushi Ohtani, Tetsuro Mizuta
Summary: This study compared the clinical superiority of dhPET and wbPET systems in acquiring brain images. The dhPET images were visually better and had higher SUVRs than wbPET images. Although there were regional accumulation differences, understanding this phenomenon will enhance the clinical use of the dhPET system.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Engineering, Biomedical
Dennis R. Schaart
Summary: The review discusses the impressive evolution of imaging performance in clinical PET systems over the past years, focusing on the optimization of TOF detectors. It emphasizes the importance of timing performance optimization in maximizing the value of PET systems, especially in personalized medicine.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Emilie Gaudin, Christian Thibaudeau, Louis Arpin, Jean-Daniel Leroux, Maxime Toussaint, Jean-Francois Beaudoin, Jules Cadorette, Maxime Paille, Catherine M. Pepin, Konin Koua, Jonathan Bouchard, Nicolas Viscogliosi, Caroline Paulin, Rejean Fontaine, Roger Lecomte
Summary: LabPET II is a new PET technology platform designed for high-resolution imaging, achieving submillimetric spatial resolution in preclinical and clinical settings. Results show promising capabilities for biomolecular imaging in preclinical research, with submillimetric resolution achieved in hot spot phantoms and exceptional contrast for tiny bone structures in mice.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Medicine, General & Internal
Eduardo Calderon, Fabian P. Schmidt, Wenhong Lan, Salvador Castaneda-Vega, Andreas S. Brendlin, Nils F. Trautwein, Helmut Dittmann, Christian la Fougere, Lena Sophie Kiefer
Summary: PET/CT scanners with long axial field-of-view (LAFOV) can adjust imaging parameters by reducing injected activity or shortening acquisition time. The ultra-high sensitivity (UHS) mode in the Biograph Vision Quadra improves image quality, noise, and lesion detectability compared to the high sensitivity (HS) mode, while reducing [F-18]FDG activity doses does not significantly affect uptake parameters.
Article
Engineering, Biomedical
Edwin K. Leung, Yasser G. Abdelhafez, Eric Berg, Zhaoheng Xie, Xuezhu Zhang, Reimund Bayerlein, Benjamin Spencer, Elizabeth Li, Negar Omidvari, Aaron Selfridge, Simon R. Cherry, Jinyi Qi, Ramsey D. Badawi
Summary: This study assessed the relationship between image signal-to-noise ratio (SNR) and total-body noise-equivalent count rate (NECR) in a long axial field-of-view total-body PET system, and found that TOF-NECR may be a more accurate predictor of SNR for TOF-reconstructed images.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Nils Krah, Denis Dauvergne, Jean Michel Letang, Simon Rit, Etienne Testa
Summary: This study examines the image noise in time-of-flight (TOF) proton computed tomography (CT) systems, which are an alternative solution for estimating the residual energy of protons and helium ions after the scanned object.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Medicine, General & Internal
Longhua Yu, Shiming Huang, Siyu Wu, Jianlan Yue, Liang Yin, Zhichun Lin
Summary: The study aimed to compare the efficacy of different dual time 18F-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) with forced diuresis in diagnosing prostate cancer (PCa). 273 male patients with focal F-18-FDG uptake in the prostate gland during PET/CT imaging were retrospectively reviewed. Results showed that delayed diuresis imaging significantly increased the SUVmax and retention index in PCa group compared to the control group. The diagnostic sensitivity and accuracy improved with delayed imaging, especially at the 2-hour interval.
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin A. Spencer, Eric Berg, Jeffrey P. Schmall, Negar Omidvari, Edwin K. Leung, Yasser G. Abdelhafez, Songsong Tang, Zilin Deng, Yun Dong, Yang Lv, Jun Bao, Weiping Liu, Hongdi Li, Terry Jones, Ramsey D. Badawi, Simon R. Cherry
Summary: This study presents a detailed physical characterization and performance evaluation of the world's first total-body PET scanner with a 194 cm AFOV. Results demonstrate high sensitivity, good spatial resolution, excellent image quality, and contrast recovery across the entire field of view, supporting the system's ultra-high performance in both phantom and human imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Xiaomin Li, Wanchun Zhang
Summary: The study explored the feasibility and safety of guided retroperitoneal puncture biopsy using fused 18 F-FDG PET/CT images. The results showed that the technique was accurate and successful in diagnosing retroperitoneal masses, providing clear pathological and immunohistochemical results. The procedure was safe, with no severe complications observed.