Article
Health Care Sciences & Services
Chi-Hung Liu, Bing-Shen Huang, Chien-Yu Lin, Chih-Hua Yeh, Tsong-Hai Lee, Hsiu-Chuan Wu, Chien-Hung Chang, Ting-Yu Chang, Kuo-Lun Huang, Jian-Lin Jiang, Joseph Tung-Chieh Chang, Yeu-Jhy Chang
Summary: This study aimed to investigate the frequency of cervical-cranial vascular complications soon after radiation therapy (RT) among patients with head and neck cancer (HNC) and identify differences between different types of HNC. The results showed that significant carotid artery stenosis (CAS) was more frequently observed within 5 years of RT among non-nasopharyngeal carcinoma (NPC) HNC patients compared to NPC patients. It was recommended to start carotid artery surveillance earlier for non-NPC HNC patients, while vascular surveillance could be deferred to 5 years after RT completion for NPC patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Olivier Van Hoey, Liliana Stolarczyk, Jan Lillhoek, Linda Eliasson, Natalia Mojzeszek, Malgorzata Liszka, Ali Alkhiat, Vladimir Mares, Francois Trompier, Sebastian Trinkl, Immaculada Martinez-Rovira, Maite Romero-Exposito, Carles Domingo, Ondrej Ploc, Roger Harrison, Pawel Olko
Summary: Out-of-field patient doses in proton therapy are primarily caused by neutrons. Currently, treatment planning systems do not take these doses into account. There is a growing need to incorporate out-of-field doses, particularly when treating children, pregnant patients, and patients with implants. This study presents the initial steps towards developing a tool to predict out-of-field neutron doses in pencil beam scanning proton therapy facilities.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
E. Borderias-Villarroel, A. Fredriksson, S. Cvilic, D. Di Perri, E. Longton, J. Pierrard, X. Geets, E. Sterpin
Summary: This study compared a not adapted planning strategy with three fully automated online adaptive proton therapy (OAPT) workflows based on the same optimization method. The OAPT methods aimed to compensate for anatomical changes in head and neck cancer patients by mimicking different dose distributions. The results showed that all OAPT strategies achieved higher target coverage compared to no adaptation, with OADEF and OAML performing the best.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Dana Keilty, Mohammad Khandwala, Zhihui Amy Liu, Vicky Papaioannou, Eric Bouffet, David Hodgson, Ryan Yee, Sharon Cushing, Normand Laperriere, Sameera Ahmed, Donald Mabbott, Vijay Ramaswamy, Uri Tabori, Annie Huang, Ute Bartels, Derek S. Tsang
Summary: This study evaluated the incidence and risk factors of hearing loss in patients with multiple ototoxic exposures, finding associations between hearing loss and factors such as mean cochlea dose, chemotherapy dose, and time since radiotherapy. A mean cochlea dose of <= 30 Gy is recommended to reduce the risk of hearing loss.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Otorhinolaryngology
Ida E. Albertsen, Nina M. Lyhne, Torben B. Larsen, Peter B. Nielsen
Summary: VTE risk exists in head and neck surgery for both patients with and without cancer, with a higher risk among cancer patients. Risk stratification tools should be developed to recognize this hazard in cancer patients undergoing head and neck surgery to support clinical decision making on anticoagulation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Leslie Chang, Sherif G. Shaaban, Emile Gogineni, Brandi Page, Harry Quon, Heng Li, Rachel Ger
Summary: This retrospective study aimed to evaluate the absolute fractional deviation for dose and volume treatment metrics using 3 mm vs. 5 mm setup robustness in patients treated with head and neck proton therapy. The results showed that deviations from planning clinical target volumes were greater using 3 mm setup robustness, and the variation was greater for patients with primary and secondary clinical targets. However, the average fractional deviation was less than 1% in primary targets and up to 2% in secondary targets using 3 mm setup uncertainty. Robust optimization using 3 mm setup uncertainty with daily CBCT is recommended for patients being treated with proton head and neck therapy.
Article
Engineering, Biomedical
Ying Zhang, Stacey McGowan Holloway, Megan Zoe Wilson, Jailan Alshaikhi, Wenyong Tan, Gary Royle, Esther Bar
Summary: This study proposed two anatomical models for predicting anatomical changes during radiotherapy for head and neck patients. The models were able to reduce CT number differences, contour errors, and proton spot location deviations, improving anatomical prediction during treatment.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Physical
Samira Kamrani, Nima Kasraie, Fatemeh Jahangiri, Davood Khezerloo, Peyman Sheikhzadeh
Summary: The purpose of this study was to calculate the organ doses, effective doses, and cancer risk from head and neck CT scans. Two techniques were used to determine the effective dose, and organ doses were computed using tissue weighting factors. The study found that females had higher mean effective doses and cancer risk compared to males. These findings will assist physicians in optimizing dose administration for head and neck CT examinations.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Oncology
Michelle Oud, Sebastiaan Breedveld, Marta Gizynska, Michiel Kroesen, Stefan Hutschemaekers, Steven Habraken, Steven Petit, Zoltan Perko, Ben Heijmen, Mischa Hoogeman
Summary: This study proposes and evaluates a new approach in intensity modulated proton therapy, which involves the daily selection of plans from patient-specific pre-treatment established plan libraries for treatment. Compared to daily online re-planning, this approach is simpler and reduces the risk of xerostomia and dysphagia, while improving adherence to target coverage constraints.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Hyun-Keun Kwon, Kyung-Do Han, Yong-Il Cheon, Sung-Chan Shin, Minhyung Lee, Eui-Suk Sung, Jin-Choon Lee, Byung-Joo Lee
Summary: This study revealed that head and neck cancer patients have increased risks of myocardial infarction, stroke, and mortality, with the highest risk of stroke in hypopharynx cancer patients and the highest risks of myocardial infarction and mortality in patients receiving chemotherapy alone.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Arthur Lalonde, Mislav Bobic, Brian Winey, Joost Verburg, Gregory C. Sharp, Harald Paganetti
Summary: This study compared the impact of setup variations and anatomical changes on the quality of head and neck IMPT treatments. The results showed that daily online-adapted plans can achieve superior target coverage and lower dose to organs at risk compared to robust optimization methods.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Dirk Wagenaar, Roel G. J. Kierkels, Arjen van der Schaaf, Arturs Meijers, Daniel Scandurra, Nanna M. Sijtsema, Erik W. Korevaar, Roel J. H. M. Steenbakkers, Antje C. Knopf, Johannes A. Langendijk, Stefan Both
Summary: This study aimed to establish optimal robust optimization uncertainty settings for head and neck cancer patients undergoing proton therapy. Results showed that with a 2 mm/3% setup/range uncertainty setting, the primary and prophylactic CTV were adequately covered, and organ-at-risk dose and normal tissue complication probabilities were reduced. Additional studies with a larger cohort are needed to further substantiate the clinical introduction of margin reduction below 3 mm/3%.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Engineering, Biomedical
Ying Zhang, Jailan Alshaikhi, Wenyong Tan, Gary Royle, Esther Bar
Summary: In this study, an anatomical model based on population statistics was developed for anatomical robust optimization in head and neck cancer proton therapy. The model was evaluated using proton spot location deviation and dose distribution, and showed improved estimation accuracy of anatomical uncertainty compared to previous models.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Hitoshi Kanno, Hironori Nagata, Akihiro Ishiguro, Satoshi Tsuzuranuki, Shintaro Nakano, Takahiro Nonaka, Koushin Kiyohara, Toshinari Kimura, Akihiko Sugawara, Yuzuru Okazaki, Shinichi Takae, Tetsuo Nakabayashi, Hiroyuki Arai, Hiroshi Suzuki
Summary: The Japanese Ministry of Health approved a drug called borofalan (B-10) for boron neutron capture therapy (BNCT) in March 2020. The drug demonstrated significant efficacy in an open-label, uncontrolled trial for patients with unresectable head and neck cancer. The study emphasized the importance of monitoring and precautions for potential side effects when applying BNCT to patients.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.