Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 54, Issue 8, Pages 2493-2509Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/54/8/016
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Funding
- EPSRC
- National Institutes of Health (NIH) [5U54CA126513-029001]
- EPSRC [EP/D077141/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D077141/1] Funding Source: researchfish
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The accuracy of the commonly used diffusion approximation as used in diffuse optical tomography is known to be limited in cases involving strong absorption and in these situations a higher ordered approximation is necessary. In this study, a light transport model has been developed based upon the three-dimensional frequency-domain simplified spherical harmonics (SPN) approximation for orders up to N = 7. The SPN data are tested against a semi-infinite multi-layered Monte Carlo model. It has been shown that the SPN approximation for higher orders (N > 1) provides an increase in accuracy over the diffusion equation specifically near sources and at boundaries of regions with increased optical absorption. It is demonstrated that the error of fluence calculated near the sources between the diffusion approximation and the SPN model (N = 7) can be as large as 60%, therefore limiting the use of the diffusion approximation for small animal imaging and in situations where optical changes near sources are critical for tomographic reconstructions.
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