Article
Physics, Multidisciplinary
Nikos Efthimiou, John D. Wright, Luke Clayton, Isaline Renard, Federico Zagni, Paulo R. R. V. Caribe, Stephen J. Archibald, Christopher J. Cawthorne
Summary: Increasing throughput in small animal preclinical studies using PET scanning can improve efficiency, but having multiple off-centre subjects may affect image quality. Simulation results showed an increase in scatter fraction in dual scatter phantom cases, leading to decreased image quality in dual animal scanning scenarios.
FRONTIERS IN PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuguang Chen, Yushen Gu, Haojun Yu, Xin Chen, Tuoyu Cao, Lingzhi Hu, Hongcheng Shi
Summary: This study evaluated the PET performance of the third commercially available whole-body integrated PET/MR system. The measurement results showed comparable performance with other state-of-the-art PET/MR systems. Clinical scans revealed similar image quality between the PET/MR and PET/CT systems.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashok Tiwari, Michael Merrick, Stephen A. Graves, John Sunderland
Summary: This study assessed the potential of a GE Healthcare SiPM-based Discovery MI system to be used as a whole-body PET scanner using Monte Carlo simulations. The study validated a four-ring scanner model and extended it to simulate scanners with different ring numbers. The results showed that extending the axial field-of-view (AFOV) could significantly improve sensitivity and count rate performance, although axial resolution might be affected. The findings were consistent with published measurements.
Article
Engineering, Biomedical
Reimund Bayerlein, Benjamin A. Spencer, Yasser G. Abdelhafez, Simon R. Cherry, Ramsey D. Badawi, Negar Omidvari
Summary: This study quantifies the systematic uncertainties of CRC measurements in PET imaging and highlights the importance of scanner-independent parameters on the reliability and reproducibility of these measurements. The findings emphasize the trade-off between voxel size and noise-induced CRC fluctuations and suggest adjustments to the current NEMA IQ standards.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Konstantinos G. Zeimpekis, Fotis A. Kotasidis, Martin Huellner, Alexandra Nemirovsky, Philipp A. Kaufmann, Valerie Treyer
Summary: The performance of a 6-ring DMI PET/CT system was evaluated and compared to the 5-ring configuration. The study showed that the 6-ring system had higher sensitivity and improved image quality in shorter scan times.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gaelle Emvalomenos, Sofie Trajanovska, Binh T. T. Pham, Peter Doughty, Jerome Burnet, Isabelle Smith, Ruslan Garipov, Marie-Claude Gregoire, Nana Sunn, John McGrath, Steven R. Meikle
Summary: This study evaluated the performance of a preclinical PET insert in three configurations: stand-alone, inside a 3T MRI bore, and during simultaneous PET/MRI scans. Results showed that the performance of the PET insert and MRI system was not significantly affected by the scanning mode.
Review
Radiology, Nuclear Medicine & Medical Imaging
Stephen S. Adler, Jurgen Seidel, Peter L. Choyke
Summary: The classical goal of PET imaging is to obtain an accurate estimate of positron-emitting radiotracer quantity in the smallest volume using the least radioactivity. However, technical issues limit system performance, and progress in PET relies on cumulative innovations throughout the imaging process.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Stina Syvanen, Silvio R. Meier, Sahar Roshanbin, Mengfei Xiong, Rebecca Faresjo, Tobias Gustavsson, Gillian Bonvicini, Eva Schlein, Ximena Aguilar, Ulrika Julku, Jonas Eriksson, Dag Sehlin
Summary: Positron emission tomography (PET) is a medical imaging technique that has become important in clinical trials of drugs against Alzheimer's disease (AD). PET data contributed to the approval of aducanumab, an antibody targeting amyloid-beta (A beta) aggregates, by showing a dose-dependent reduction in brain amyloid. PET is also useful in preclinical studies with animal models of A beta pathology. It allows for longitudinal studies and has high translatability between species.
PHARMACEUTICAL RESEARCH
(2022)
Article
Computer Science, Interdisciplinary Applications
Alexandros Vrachliotis, George A. Kastis, Nicholas E. Protonotarios, Athanasios S. Fokas, Stephan G. Nekolla, Constantinos D. Anagnostopoulos, Lena Costaridou, Anastasios Gaitanis
Summary: The study compared the Spline Reconstruction Technique (SRT) with other algorithms for image reconstruction, showing that SRT achieved higher Recovery Coefficient values for small hot regions of interest. Additionally, SRT exhibited significant improvements in Spill-Over Ratio and Cold Region Contrast compared to other algorithms, even at equal noise levels. The Tera-Tomo 3D algorithm performed remarkably well for all figures-of-merit.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiong Liu, Chaofan Li, Jiguo Liu, Kishore Krish, Xinlei Fu, Jie Zhao, Jyh-Cheng Chen
Summary: The evaluation of the Metis(TM) PET/CT system showed high resolution, high sensitivity, and excellent image quality characteristics, making it suitable for rodent imaging-based research.
Article
Nuclear Science & Technology
Hankyeol Song, In Soo Kang, Kyu Bom Kim, Chanwoo Park, Min Kyu Baek, Seongyeon Lee, Yong Hyun Chung
Summary: A novel rectangular-shaped PET system with an adjustable gantry (AGPET) has been developed, utilizing a new depth of interaction (DOI) method and digital time pickoff method. Experimental results demonstrate that the AGPET system provides higher sensitivity and resolution for small animal imaging.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2021)
Review
Chemistry, Analytical
Hyunjun Kye, Yuon Song, Tsedendamba Ninjbadgar, Chulhong Kim, Jeesu Kim
Summary: This article explores and summarizes the use of photoacoustic imaging in whole-body imaging of small animals. Photoacoustic imaging enables visualization of optical absorption properties at deeper imaging depths. In preclinical studies, it is widely used to visualize the molecular-level biodistribution in small animals. The future research direction of achieving deeper imaging depth and faster imaging speed is also discussed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Minjee Seo, Guen Bae Ko, Kyeong Yun Kim, Jeong-Whan Son, Jung Woo Byun, Yun-Sang Lee, Kyeong Min Kim, Jang Woo Park, Kipom Kim, Taekwan Lee, Jae Sung Lee
Summary: SimPET-L and SimPET-XL have larger transaxial fields of view (FOV) compared with their predecessors, allowing for whole-body PET imaging of rats. Performance evaluations and rat-body imaging studies demonstrate the benefits of increased axial and transaxial FOVs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyi Cheng, Dongxu Yang, Debabrata Saha, Xiankai Sun, Yiping Shao
Summary: We integrated a compact and lightweight PET with an existing CT image-guided small animal irradiator for practical onboard PET/CT image-guided preclinical radiation therapy research. The integrated system showed a mean PET/CT image registration error of approximately 0.3 mm. The results demonstrated that integrated PET/CT/RT can significantly enhance the accuracy of tumor delineation and radiation targeting, enabling breakthrough preclinical RT research and applications.
Article
Neurosciences
Takuya Toyonaga, Arman Fesharaki-Zadeh, Stephen M. Strittmatter, Richard E. Carson, Zhengxin Cai
Summary: The development of novel PET imaging agents for SV2A allowed for the in vivo detection of synaptic density changes, and preclinical SV2A PET imaging in animal models provides supporting information. This article discusses key considerations when designing preclinical SV2A PET imaging studies and strategies for data analysis, as well as the challenges and opportunities in small animal SV2A PET imaging.
FRONTIERS IN NEUROSCIENCE
(2022)