Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth Huynh, Sara Boyle, Jennifer Campbell, Jessica Penney, Raymond H. Mak, Jonathan D. Schoenfeld, Jonathan E. Leeman, Christopher L. Williams
Summary: This study assessed the feasibility of using MR-Linac for laryngeal cancer treatment by imaging a healthy volunteer and creating a simulated larynx phantom. The results showed that it is possible to treat laryngeal cancer patients on the MR-Linac.
Article
Computer Science, Interdisciplinary Applications
Niek R. F. Huttinga, Tom Bruijnen, Cornelis A. T. Van den Berg, Alessandro Sbrizzi
Summary: The MR-Linac combines an MR-scanner and radiotherapy linear accelerator to improve the precision of radiotherapy treatments. This work presents a method for real-time non-rigid 3D respiratory motion estimation with low latency, which is crucial for MR-guided radiotherapy.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Medicine, General & Internal
Morgan Michalet, Ons Bettaieb, Samia Khalfi, Asma Ghorbel, Simon Valdenaire, Pierre Debuire, Norbert Ailleres, Roxana Draghici, Mailys De Meric De Bellefon, Marie Charissoux, Pierre Boisselier, Sylvain Demontoy, Alexis Marguerit, Morgane Cabaille, Marie Cantaloube, Aicha Keskes, Touria Bouhafa, Marie-Pierre Farcy-Jacquet, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Stereotactic MR-guided Radiotherapy (MRgRT) is an interesting treatment option for adrenal gland metastases (AGM). This study reviewed data from 12 consecutive patients treated with MRgRT for AGM and assessed the treatment's impact on target volume coverage, organ protection, local control, and overall survival. The results showed improved dosimetric quality and good tolerance of the treatment, with high rates of local control and overall survival. Longer follow-up is needed to evaluate late toxicities and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Juliane Hoerner-Rieber, Sebastian Klueter, Jurgen Debus, Gosse Adema, Marleen Ansems, Marcel Verheij
Summary: Recent studies have shown the benefits of integrating radiotherapy and immunotherapy, with the emergence of magnetic resonance guided radiotherapy providing new opportunities for improving treatment efficacy and reducing toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
James W. Randall, Nikhil Rammohan, Indra J. Das, Poonam Yadav
Summary: Advances in image-guided radiotherapy, particularly the application of magnetic resonance imaging (MRI), have improved oncologic outcomes and reduced toxicity. The integration of MRI with a linear accelerator in the MR-Linac provides real-time imaging, motion management assessment, and online adaptive therapy, offering potential advantages in different clinical scenarios and enhancing the future role of these machines in clinical workflows.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Isak Wahlstedt, Abraham George Smith, Claus Erik Andersen, Claus Preibisch Behrens, Susanne Norring Bekke, Kristian Boye, Mette van Overeem Felter, Mirjana Josipovic, Jens Petersen, Signe Lenora Risumlund, Jose David Tascon-Vidarte, Janita Elizabeth van Timmeren, Ivan Richter Vogelius
Summary: This study investigates the inter-algorithm variation of dose accumulation for MR-guided liver SBRT, and found that intensity-based algorithms are more consistent with planned dose. It suggests not relying on a single algorithm for dose accumulation.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Medicine, General & Internal
Nikhil Rammohan, James W. Randall, Poonam Yadav
Summary: This review discusses the technological advancements in image-guided radiotherapy (IGRT) with a focus on magnetic resonance guided radiotherapy (MRgRT), including the historical timeline, current available technology, and future directions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chen-Yu Huang, Bin Yang, Wai Wang Lam, Hui Geng, Kin Yin Cheung, Siu Ki Yu
Summary: MR-guided radiotherapy (MRgRT) is a significant advancement in radiotherapy, allowing for more precise treatment through visualization of patient anatomical and physiological changes during the course of treatment. However, understanding the dose effects induced by the magnetic field and their impact on treatment quality and outcomes is crucial before MR-linacs can fully deliver safe and accurate treatments.
Review
Oncology
Daniela Thorwarth, Daniel A. Low
Summary: MR-guided cancer treatment technology has the potential to revolutionize the field of radiotherapy, but still faces technical challenges such as magnetic field strength tradeoffs, limitations of purely MR-based RT workflows, and the potential of real-time 3D MR imaging for real-time RT.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Adham Hijab, Boris Tocco, Ian Hanson, Hanneke Meijer, Christina Junker Nyborg, Anders Smedegaard Bertelsen, Robert Jan Smeenk, Gillian Smith, Jeff Michalski, Brian C. Baumann, Shaista Hafeez
Summary: Radiotherapy plays a significant role in both curative and palliative treatment of bladder cancer, but faces technical challenges such as poor tumor visualization and bladder size variability. Magnetic resonance imaging (MRI) is favored for tumor visualization and staging, and the integration of MRI scanning with linear accelerator in MR-Linac systems allows for real-time plan adaptation during treatment, potentially improving outcomes for bladder cancer patients. However, robust evidence is needed to determine if MR-guided radiotherapy translates into better patient outcomes before widespread clinical implementation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Karl Bordeau, Morgan Michalet, Aicha Keskes, Simon Valdenaire, Pierre Debuire, Marie Cantaloube, Morgane Cabaille, William Jacot, Roxana Draghici, Sylvain Demontoy, Xavier Quantin, Marc Ychou, Eric Assenat, Thibault Mazard, Ludovic Gauthier, Marie Dupuy, Boris Guiu, Celine Bourgier, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Liver stereotactic body radiotherapy (SBRT) provides effective local control and minimal toxicity for liver metastases. This study presents the first clinical results of stereotactic MR-guided radiotherapy (MRgRT) for liver metastases from a prospective registry. The treatment was well-tolerated, with low rates of acute and late toxicities. The overall survival and local control rates were promising, but distant relapse remains a challenge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Luca Boldrini, Stefanie Corradini, Cihan Gani, Lauren Henke, Ali Hosni, Angela Romano, Laura Dawson
Summary: MR guided radiotherapy for liver malignancies shows potential clinical advantages but also current limitations. By better visualizing therapy volumes and utilizing innovative adaptive radiotherapy and motion management approaches, more efficient treatment delivery and potentially improved clinical outcomes can be achieved.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sebastian Regnery, Carolin Buchele, Fabian Weykamp, Moritz Pohl, Philipp Hoegen, Tanja Eichkorn, Thomas Held, Jonas Ristau, Carolin Rippke, Laila Koenig, Michael Thomas, Hauke Winter, Sebastian Adeberg, Juergen Debus, Sebastian Klueter, Juliane Hoerner-Rieber
Summary: This study explores the benefit of adaptive magnetic resonance-guided stereotactic body radiotherapy for lung tumors, particularly ultracentral lung tumors. The results show that plan adaptation can effectively improve the shortcomings of predicted plans and reduce the risk of exceeding maximum dose and violating organ-at-risk constraints.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Petra J. van Houdt, Hina Saeed, Daniela Thorwarth, Clifton D. Fuller, William A. Hall, Brigid A. McDonald, Amita Shukla-Dave, Ernst S. Kooreman, Marielle E. P. Philippens, Astrid L. H. M. W. van Lier, Rick Keesman, Faisal Mahmood, Catherine Coolens, Teodor Stanescu, Jihong Wang, Neelam Tyagi, Andreas Wetscherek, Uulke A. van der Heide
Summary: QIBs derived from MRI techniques have the potential for personalized cancer treatment, with MRI-guided radiotherapy systems allowing for high-frequency imaging and reduced patient burden. Understanding the correlation between QIBs collected during MRIgRT and clinical outcomes is crucial, as technical validation plays an important role in this process.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Lori L. Rodriguez, Rupesh Kotecha, Martin C. Tom, Michael D. Chuong, Jessika A. Contreras, Tino Romaguera, Diane Alvarez, James McCulloch, Robert Herrera, Rene J. Hernandez, Jairo Mercado, Minesh P. Mehta, Alonso N. Gutierrez, Kathryn E. Mittauer
Summary: The study compared the treatment efficacy between adaptive IMRT MRgRT(BH) and VMAT CT-IGRT(BH). The results showed that MRgRT(BH) was able to safely deliver ablative doses with real-time motion tracking, providing better target coverage and conformality. However, CT-IGRT(BH) demonstrated superior performance in terms of target coverage and gastrointestinal organ-at-risk doses.
RADIOTHERAPY AND ONCOLOGY
(2022)