Article
Pathology
Alexandros D. Polydorides, Qingqing Liu
Summary: The study reviewed 162 patients with small bowel NETs and found that primary tumor size and lymphovascular invasion were associated with lymph node metastasis, while TDs and higher pT stage were associated with distant metastasis. A cutoff of >= 7 positive lymph nodes predicted distant metastasis, and the modified pN stage was a better predictor than the prototypical pN stage. Higher pNmod and pM were associated with disease progression, worse progression-free survival, and worse disease-specific survival.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Hyung Kyu Park, Ghee Young Kwon
Summary: This study compared the metastatic patterns of neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and non-neuroendocrine neoplasms (non-NENs), and found significant differences between NETs/NECs and non-NENs. The key factor causing these differences may be associated with the multigene program of neuroendocrine differentiation.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Oncology
Yi-Wei Li, Yi-Ping He, Fang-Qi Liu, Jun-Jie Peng, San-Jun Cai, Ye Xu, Ming-He Wang
Summary: This study compared the clinicopathologic features of rectal neuroendocrine tumors (NETs) with G1 and G2 grades. The results showed that G2 tumors were larger and more invasive than G1 tumors, with a significantly higher incidence of lymph node metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Sami Matrood, Leonidas Apostolidis, Joerg Schrader, Sebastian Krug, Harald Lahner, Annette Ramaswamy, Damiano Librizzi, Zoltan Kender, Anke Kroecher, Simon Kreutzfeldt, Thomas Matthias Gress, Anja Rinke
Summary: The study found that presacral NENs are histopathologically similar to rectal NENs. The majority of tumors are non-functioning, and PRRT shows promising activity in treatment. Further investigation and molecular characterization are needed to understand this rare tumor entity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Hilary R. Keller, Sri H. Senapathi, Anthony Morada, David Bertsch, Burt Cagir
Summary: This study evaluated the 5-year overall survival (OS) and cancer-specific survival (CSS) of neuroendocrine neoplasms (NENs) of the colon, rectum, and small intestine (SI). The results showed that well-differentiated neuroendocrine tumors (NETs) of the rectum had improved 5-year OS. However, rectal poorly-differentiated neuroendocrine carcinomas (NECs) had lower 5-year OS compared to colon and SI. More frequent surveillance and timely initiation of systemic therapy should be considered for rectal NECs.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Daisuke Takayanagi, Hourin Cho, Erika Machida, Atsushi Kawamura, Atsuo Takashima, Satoshi Wada, Takuya Tsunoda, Takashi Kohno, Kouya Shiraishi
Summary: This review provides updates on the epidemiology, diagnosis, and management of gastroenteropancreatic neuroendocrine neoplasms. The incidence of these malignancies originating from the pancreatic and gastrointestinal neuroendocrine cell system has been increasing. Advances in molecular diagnosis, treatment strategies, and liquid biopsy have contributed to personalized management for patients.
Article
Oncology
Yuanxiang Lu, Wensen Li, Senmao Mu, Lianyuan Tao, Guoyi Yan, Erwei Xiao, Liancai Wang, Deyu Li
Summary: This study investigated the prognostic significance of tumor budding in Grade 1-2 PNETs and found that high-grade budding is associated with aggressive histopathological parameters and is an independent predictive factor for postoperative liver metastasis. PNETs with high-grade budding also have worse overall survival and disease-free survival. Incorporating tumor budding into histopathological reports may aid in appropriate clinical management.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biology
Leonidas Apostolidis, Jorg Schrader, Henning Jann, Anja Rinke, Sebastian Krug
Summary: This study evaluated central nervous system involvement in patients with neuroendocrine neoplasms, particularly focusing on leptomeningeal carcinomatosis (LC). LC is associated with poor prognosis, and optimal treatment strategies are needed. Common symptoms include motor and sensory deficits as well as vigilance abnormalities.
Article
Oncology
Zhenglin Yi, Renyu Liu, Jiao Hu, Tongchen He, Zihao Wang, Yangle Li, Xiongbing Zu
Summary: The characteristics of primary renal neuroendocrine neoplasms and their relationships with overall survival were analyzed in the largest cohort to date, with 132 cases. Age, sex, and tumor size and stage were found to be associated with poor prognosis.
CLINICAL GENITOURINARY CANCER
(2021)
Article
Endocrinology & Metabolism
Marta Opalinska, Anna Sowa-Staszczak, Helena Olearska, Magdalena Ulatowska-Bialas, Aleksandra Gilis-Januszewska, Alicja Hubalewska-Dydejczyk
Summary: Ovarian neuroendocrine tumors are rare neoplasms that most commonly occur within mature cystic teratomas, with a minority presenting as monodermal teratomas (strumal carcinoid). The prognosis for patients with ovarian neuroendocrine tumors is good, with surgical intervention proving to be an effective treatment method.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Kiyoun Yi, Gwang Ha Kim, Su Jin Kim, Cheol Woong Choi, Moon Won Lee, Bong Eun Lee, Geun Am Song
Summary: Endoscopic resection provides favorable long-term outcomes for d-NETs <= 10 mm in size, limited to the submucosal layer, and without lymph node or distant metastasis, when endoscopically complete resection is achieved.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Nan Zhang, Jin He, Shishir K. Maithel, George Poultsides, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, Cliff Cho, Yi Lv, Xu-Feng Zhang, Timothy M. Pawlik
Summary: Traditional imaging modalities have low sensitivity to determine nodal status among patients with pNETs, and only 4% of patients with LNM on final pathologic examination had preoperative imaging that was suspicious for LNM.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xi-Tai Huang, Jin-Zhao Xie, Liu-Hua Chen, Jian-Peng Cai, Wei Chen, Li-Jian Liang, Ning Zhang, Xiao-Yu Yin
Summary: This study aimed to evaluate the outcomes of debulking surgery for unresectable well-differentiated metastatic pancreatic neuroendocrine tumor (m-PNET) in our hospital. The results showed that patients who underwent debulking surgery had a significantly higher 5-year overall survival (OS) rate compared to those who received conservative therapy alone (87.5% vs 37.8%, log-rank P = 0.022). Furthermore, the 5-year OS rate of patients treated with debulking surgery was comparable to that of patients with resectable m-PNET receiving radical resection (87.5% vs 100%, log-rank P = 0.724).
GASTROENTEROLOGY REPORT
(2023)
Article
Surgery
Yuki Fujii, Ching-Wei Tzeng, Yi-Ju Chiang, Daniel M. Halperin, Arvind Dasari, Michael P. Kim, Matthew H. G. Katz, Jeffrey E. Lee, Naruhiko Ikoma
Summary: The study found that the presence of regional LN metastases and the extent of surgery did not affect overall survival among patients with D-NETs. Radical resection to clear occult LN metastases for nonfunctioning, sporadic D-NETs was not supported by the current study.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Oncology
Emma N. Rizen, Alexandria T. Phan
Summary: This review summarizes recent findings and updates in the management of neuroendocrine neoplasms (NENs), highlighting the improvement in NENs classification and the expansion of epidemiological understanding through global collaborations and tumor registries. The review also discusses the evolving utility of some NET biomarkers, the increasing knowledge of molecular drivers of tumorigenesis, and the multiple drug approvals for the treatment of advanced NENs. The authors emphasize the importance of further understanding molecular drivers and the role of immunotherapy in transforming care for all NENs patients.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Sanna Viitasalo, Taru Ilmarinen, Leena-Maija Aaltonen, Jaana Hagstrom, Maija Hytonen, Sari Hammaren-Malmi, Petra Pietarinen, Pia Jarvenpaa, Teemu Kinnari, Ahmed Geneid, Markus Lilja
Summary: This retrospective study assessed the epidemiological information of patients treated for sinonasal inverted papilloma (SNIP) at Helsinki University Hospital between 1984 and 2014, and found a very low malignant transformation rate of SNIP. The study also revealed that SNIP patients were not prone to HPV-associated non-sinonasal malignancies. Additionally, endoscopic resection and attachment-oriented surgery have become the predominant approaches in SNIP treatment, with a reduced recurrence rate.
Article
Biochemistry & Molecular Biology
Kathrin Barth, Verica Vasic, Brennan McDonald, Nora Heinig, Marc-Christoph Wagner, Ulrike Schumann, Cora Roehlecke, Frank Bicker, Lana Schumann, Konstantin Radyushkin, Jan Baumgart, Stefan Tenzer, Frauke Zipp, Matthias Meinhardt, Kari Alitalo, Irmgard Tegeder, Mirko H. H. Schmidt
Summary: Mature neurons, neural stem cells, and neural precursor cells secrete the neurovascular protein EGFL7 to shape the neurogenic niche of the hippocampus. Ablation of EGFL7 leads to increased neurogenesis and is correlated with elevated expression of VEGF-D. Infusion of VEGF-D increases neurogenesis, while its knockout decreases neurogenesis. Furthermore, EGFL7 knockout mice show improved spatial memory and memory consolidation in the hippocampus.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ivy K. N. Chiang, Matthew S. Graus, Nils Kirschnick, Tara Davidson, Winnie Luu, Richard Harwood, Keyi Jiang, Bitong Li, Yew Yan Wong, Mehdi Moustaqil, Emmanuelle Lesieur, Renae Skoczylas, Valerie Kouskoff, Jan Kazenwadel, Luis Arriola-Martinez, Emma Sierecki, Yann Gambin, Kari Alitalo, Friedmann Kiefer, Natasha L. Harvey, Mathias Francois
Summary: SOX7, a BEC-specific transcription factor, modulates the expression level of angiocrine signals in blood vascular endothelial cells (BECs) to pattern lymphatic vessels. It directly represses the transcription of Vegfc, a major lymphangiogenic growth factor, and interacts with HEY1 to regulate Notch pathway. Our finding reveals the importance of SOX7 in modulating downstream signaling events crucial for lymphatic patterning.
Article
Oncology
Rayan Mroueh, Elli Hirvonen, Janne Pitkaeniemi, Nea Malila, Jaana Hagstrom, Antti Makitie, Anni Virtanen
Summary: This study investigated the burden of head and neck cancer (HNC) among immigrants in Finland. The risk of HNC was not increased among first-generation male immigrants, but significantly elevated for cancer of the pharynx and larynx, and decreased for lip cancer. Female first-generation immigrants had a significantly reduced risk of HNC, while the children of first-generation immigrants did not have an increased risk of HNC.
Article
Oncology
Jussi Kasurinen, Ines Beilmann-Lehtonen, Tuomas Kaprio, Jaana Hagstrom, Caj Haglund, Camilla Bockelman
Summary: A study categorized colorectal cancer patients into four phenotypic subgroups using immunohistochemistry and found associations between these subgroups and patient prognosis and clinicopathological variables. The immune subgroup showed the best 5-year disease-specific survival rate, while the mesenchymal subgroup had the worst prognosis. These subgroups' associations and prognoses resemble the transcriptome-based consensus molecular subtypes (CMS) classification.
Article
Cell Biology
Toni T. Lemmetyinen, Emma W. Viitala, Linnea Wartiovaara, Tuomas Kaprio, Jaana Hagstrom, Caj Haglund, Pekka Katajisto, Timothy C. Wang, Eva Domenech-Moreno, Saara Ollila
Summary: Growth factors secreted by stromal fibroblasts, such as NRG1 and EREG, play a crucial role in regulating the intestinal epithelium. NRG1 promotes epithelial regeneration and protects against radiation-induced damage, while also suppressing the stem cell pool and remodeling the actin cytoskeleton. Interestingly, NRG1 does not support the growth of pre-tumorigenic intestinal organoids lacking the tumor suppressor Apc, suggesting a tumor-suppressive function.
DISEASE MODELS & MECHANISMS
(2023)
Article
Immunology
Zhilin Li, Salli Antila, Harri Nurmi, Dmitri Chilov, Emilia A. Korhonen, Shentong Fang, Sinem Karaman, Britta Engelhardt, Kari Alitalo
Summary: The recent discovery of lymphatic vessels in the dura mater has potential implications for alternative therapeutics in CNS disorders. However, inhibiting the VEGF-C/VEGFR3 signaling pathway does not affect the development of CNS autoimmunity, suggesting that dural lymphatic vessels do not directly contribute to CNS autoimmunity.
SCIENCE IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Karita Nylund, Jaana Helenius-Hietala, Fredrik Aberg, Jaana Hagstrom, Hellevi Ruokonen
Summary: Oral mucosal lesions can persist for years before symptoms or diagnosis of inflammatory bowel disease (IBD) and subsequent primary sclerosing cholangitis (PSC). Since a dental practitioner may be the first clinician to suspect IBD with extraintestinal manifestations (EIMs), early referral and close collaboration with a gastroenterologist are recommended.
CLINICAL CASE REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Piia Huopainen, Sirke Virkkunen, Johanna Snall, Arzu Tezvergil-Mutluay, Jaana Hagstrom, Satu Apajalahti
Summary: This study aimed to compare the detectability of periapical foreign materials in dentoalveolar imaging and histopathology. The results showed that histopathology was more accurate in diagnosing periapical foreign bodies or foreign body reactions. Clinicians should be aware of the limitations of imaging when diagnosing and planning treatment.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Orvokki Saraneva, Jussi Furuholm, Jaana Hagstrom, Timo Sorsa, Ville Rita, Taina Tervahartiala, Hannamari Valimaa, Hellevi Ruokonen
Summary: This retrospective study explored the role of oral potentially malignant disorders and the presence of intraepithelial Candida hyphae in the development of oral tongue squamous cell carcinoma. The results showed significant associations between histopathological diagnosis of oral lichen planus/lichenoid reaction and the presence of Candida hyphae with female gender. Patients with oral lichen planus/lichenoid reaction were less likely to be smokers, while Candida hyphae were more frequently observed in patients without alcohol use. Therefore, careful monitoring is necessary for these patients despite the absence of classical risk factors.
Article
Multidisciplinary Sciences
Heini Nieminen, Pirjo Nummela, Tero Satomaa, Annamari Heiskanen, Jukka O. O. Hiltunen, Tuomas Kaprio, Hanna Seppanen, Jaana Hagstrom, Harri Mustonen, Ari Ristimaki, Caj Haglund
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are potentially malignant cystic tumors of the pancreas. Diagnostic methods are needed to recognize IPMNs with malignant potential. Aberrantly expressed glycans offer interesting new options for diagnostics.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Sirke Virkkunen, Jaana Willberg, Caj Haglund, Malin Sund, Timo Sorsa, Jaana Hagstroem
Summary: The aim of this study was to investigate the immunexpression of bacterial lipopolysaccharide (LPS) in periapical lesions. Surprisingly, we found that Rushton bodies (RBs), whose origin has been debated, were positive for LPS. Staining of radicular cyst samples showed that all RBs (N=25) present in the tissue samples were positive for LPS, and calcification in the cyst capsule also showed immunopositivity. This study demonstrates for the first time that LPS is present in RBs, suggesting that the host response to bacteria may be the initial cause of RB formation and cyst capsule calcifications.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Letter
Oncology
Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Mustafa Yilmaz, Ilknur Harmankaya, Didem Karacetin, Turgut Ipek, Ulvi Kahraman Gursoy, Shipra Gupta, Ismo T. Raisanen, Jaana Hagstrom, Jaana Rautava, Timo Sorsa
Article
Pathology
Anni Sjoblom, Henna Pehkonen, Lauri Jouhi, Outi Monni, Reija Randen-Brady, Piia-Riitta Karhemo, Jussi Tarkkanen, Caj Haglund, Petri Mattila, Antti Makitie, Jaana Hagstrom, Timo Carpen
Summary: Liprin-alpha 1 inhibits the expression of CD82 and its increased expression in tumor-infiltrating lymphocytes is associated with a favorable prognosis in HPV-positive patients with oropharyngeal squamous cell carcinoma.
HEAD & NECK PATHOLOGY
(2023)
Letter
Oncology
Shipra Gupta, Ismo T. Raisanen, Hanna Seppanen, Jaana Hagstrom, Andreas Grigoriadis, Kethe Hermunen, Dimitra Sakellari, Caj Haglund, Timo Sorsa