Journal
VIRAL IMMUNOLOGY
Volume 28, Issue 3, Pages 153-160Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2014.0095
Keywords
-
Categories
Funding
- Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization (DRDO), Ministry of Defence, India [TASK-177]
- Department of Science and Technology, government of India
Ask authors/readers for more resources
Dengue virus (DENV) causes a febrile disease, infecting around 50-100 million people annually. The relationship between DENV proteins and host cellular responses during infection is unclear. This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in viral immunopathogenesis. Host viral protein interactions were studied by co-immunoprecipitation and co-localization. It was found that PDI interacts with DENV nonstructural protein 1 (NS1) intracellularly as well as on the surface in the lipid raft domain. Disruption of this key interaction between PDI and NS1 could be an important therapeutic strategy to block DENV infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
