Article
Physics, Multidisciplinary
D. R. Rodrigues, A. Salimath, K. Everschor-Sitte, K. M. D. Hals
Summary: This study successfully manipulates domain walls in kagome antiferromagnets via a spin-wave source, with the speed and direction of the domain wall motion regulated by tuning the spin wave frequency. By establishing an effective action and deriving equations for spin-wave-driven domain wall motion, the frequency-dependent velocity of the spin texture is explained.
PHYSICAL REVIEW LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Cordula Reuther, Paula Santos-Otte, Rahul Grover, Georg Heldt, Guenther Woehlke, Stefan Diez
Summary: This study demonstrates a method to multiply microtubules by severing and elongating them. The method can be applied to counteract the loss of microtubules on surfaces during long-distance and long-duration movements, and it enables microtubule multiplication in physical networks.
Article
Chemistry, Multidisciplinary
Kengo Manabe, Koichiro Saito, Miki Nakano, Takuya Ohzono, Yasuo Norikane
Summary: This study demonstrates a light-driven system called a liquid conveyor, which can transport both water droplets and microsolids on the same surface. By incorporating a molecular motor with photoisomerization ability into the liquid layer, flow is induced by exposure to ultraviolet LED light, achieving horizontal transport in any direction.
Article
Chemistry, Multidisciplinary
Huiting Yang, Jinhao Yi, Shihao Pang, Kai Ye, Zhicheng Ye, Qi Duan, Zexin Yan, Cheng Lian, Yi Yang, Linyong Zhu, Da-Hui Qu, Chunyan Bao
Summary: In this study, a light-driven motor molecule called MC2 was designed to overcome the challenges of high activity, selectivity, and gating function in artificial ion channels. MC2 forms a selective K+ channel through a single molecular transmembrane mechanism, and its light-driven rotary motion increases ion transport, resulting in excellent cytotoxicity and cancer cell selectivity. Mechanistic studies showed that the rotary motion of MC2 promotes K+ efflux, generates reactive oxygen species, and activates caspase-3-dependent apoptosis in cancer cells. This strategy, combined with the advantages of light control, can be applied in the design and application of next-generation synthetic cation transporters for the treatment of cancer and other diseases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Physics, Multidisciplinary
Jesus Mateos, Charles E. Creffield, Fernando Sols
Summary: We theoretically investigate the superfluidity of a one-dimensional boson system with periodically modulated hopping energy. The system exhibits novel superfluid features such as a cat-like ground state and interference between the ground-state wave function components. The dynamics of this system is driven by correlations and described by exotic Hamiltonian and current operators. Calculation of the dynamic form factor reveals the presence of an acoustic mode that guarantees superfluidity in the thermodynamic limit.
NEW JOURNAL OF PHYSICS
(2023)
Article
Psychiatry
Bang-Sheng Wu, Ya-Ru Zhang, Hong-Qi Li, Kevin Kuo, Shi-Dong Chen, Qiang Dong, Yong Liu, Jin-Tai Yu
Summary: The study found suggestive associations of decreased surface area of the temporal pole and decreased thickness of the cuneus with higher AD risk. Additionally, there was a suggestive association of vulnerability to AD with the decreased surface area of the precentral and isthmus cingulate. The findings provide insights into the associations between cortical structure and the occurrence of AD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Chemistry, Physical
Kewei Xie, Qian Wang
Summary: This study reveals the counterintuitive cooperation phenomenon among motor proteins in intracellular transport and verifies the accuracy of the model. The results indicate that cooperation can significantly increase the transport distance, rationalizing the choice of bidirectional transport in evolution. Furthermore, the study derives the exact analytical solution for the transport distance.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Vahid Mosallanejad, Jingqi Chen, Wenjie Dou
Summary: In this paper, a Fokker-Planck equation is derived to describe nonadiabatic molecular dynamics with electronic friction for Floquet-driven systems. The breakdown of the Born-Oppenheimer approximation in strong Floquet driving is also observed.
Article
Neurosciences
Ivan Fernandez Bessone, Jordi Navarro, Emanuel Martinez, Karina Karmirian, Mariana Holubiec, Matias Alloatti, Livia Goto-Silva, Cayetana Arnaiz Yepez, Daniel Martins-de-Souza, Juliana Minardi Nascimento, Luciana Bruno, Trinidad M. Saez, Stevens K. Rehen, Tomas L. . Falzone
Summary: Increased activity of DYRK1A may play a role in the abnormal metabolism of APP, and it regulates the intracellular distribution of APP in neurons by affecting axonal transport. These findings provide insights into the potential therapeutic intervention of using DYRK1A inhibitors to restore APP axonal transport in Down's syndrome and Alzheimer's disease.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Riku Tuovinen, Robert van Leeuwen, Enrico Perfetto, Gianluca Stefanucci
Summary: The generalized Kadanoff-Baym ansatz (GKBA) provides a cost-effective way to simulate out-of-equilibrium quantum systems. Recent advancements have overcome the limitation of neglecting initial correlations in the conventional GKBA approach. In the context of quantum transport, a further extension of the GKBA approach is needed to account for the contacted nature of the initial state.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Physics, Multidisciplinary
Beatrice Ramm, Andriy Goychuk, Alena Khmelinskaia, Philipp Blumhardt, Hiromune Eto, Kristina A. Ganzinger, Erwin Frey, Petra Schwille
Summary: This study reveals a hidden function of the Escherichia coli MinDE protein system in actively transporting functionally unrelated cargo on membranes through a diffusiophoretic mechanism. This mechanism enables the sorting of diffusive objects based on their effective size. The coupling between diffusive fluxes of MinDE and non-specific cargo via density-dependent friction represents a novel physical mechanism for establishing intracellular organization.
Article
Multidisciplinary Sciences
Eran Maniv, Nityan L. Nair, Shannon C. Haley, Spencer Doyle, Caolan John, Stefano Cabrini, Ariel Maniv, Sanath K. Ramakrishna, Yun-Long Tang, Peter Ercius, Ramamoorthy Ramesh, Yaroslav Tserkovnyak, Arneil P. Reyes, James G. Analytis
Summary: It is demonstrated that the coexistence of spin glass and antiferromagnetic order allows a novel mechanism for switching the antiferromagnet Fe1/3 + delta NbS2, rooted in the electrically stimulated collective winding of the spin glass. This manipulation of antiferromagnetic spin textures using the collective dynamics of a spin glass opens up new material platforms for antiferromagnetic spintronics with complex magnetic textures.
Article
Materials Science, Multidisciplinary
Gregor Gurski, Henning Kirchberg, Peter Nalbach, Michael Thorwart
Summary: We propose a quantum-mechanical model to calculate the current through a single molecular junction immersed in a solvent and surrounded by a thin shell of bound water under an applied ac voltage. The charge current through the molecular junction under an ac voltage in the sequential tunneling regime is determined using a quantum master equation solved by a real-time diagrammatic technique. The findings show that the current is highly sensitive to both the hydration shell thickness as well as the volume fraction of the solvent mixture, suggesting potential applications in shell and concentration sensors on the molecular scale.
Article
Engineering, Electrical & Electronic
Chun Fai Lui, Yiqi Liu, Min Xie
Summary: This article proposes a data-driven dynamic soft sensor modeling method based on SBiLSTM structure, which extracts and utilizes nonlinear dynamic latent information from both process variables and quality variables to achieve efficient quality estimation.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Editorial Material
Information Science & Library Science
Shahriar Akter, Grace McCarthy, Shahriar Sajib, Katina Michael, Yogesh K. Dwivedi, John D'Ambra, K. N. Shen
Summary: Data-driven innovation has the potential to transform innovation in the age of AI, but algorithmic biases may lead to unjust data product developments. The study identifies data bias, method bias, and societal bias as the three major sources of algorithmic bias.
INTERNATIONAL JOURNAL OF INFORMATION MANAGEMENT
(2021)
Article
Mechanics
D. Bhat, S. Redner
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2019)
Article
Mechanics
Deepak Bhat, Jordi Pinero, S. Redner
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2019)
Article
Materials Science, Multidisciplinary
Deepak Bhat, Sanjoy Jena, Anu Babusenan, Jayeeta Bhattacharyya, Debdutta Ray
Article
Mechanics
Deepak Bhat, S. Redner
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2020)
Article
Biochemistry & Molecular Biology
Vandana Yadav, Balaramamahanti Srinivas, Manoj Gopalakrishnan
Summary: This study investigates the impact of barriers on the dynamics of microtubule filaments in cells and the extent of load-sharing in a microtubule bundle, analyzing their effects on catastrophe events. Theoretical models and numerical simulations are used to study the dynamic behavior and interactions between microtubules and barriers in different scenarios.
Article
Materials Science, Multidisciplinary
Deepak Bhat, Subhamoy Sahoo, Jayeeta Bhattacharyya, Debdutta Ray
ORGANIC ELECTRONICS
(2020)
Article
Physics, Multidisciplinary
Urvashi Nakul, Manoj Gopalakrishnan
Summary: This study investigates the phenomenon of protein friction in transporting cellular cargoes along the cytoskeletal filament track. Through mathematical modeling and computational simulations, the motion of motor proteins and the related drag coefficient are analyzed. Results show the relationship between motor protein friction and background damping force, as well as the behavior when multiple motors are involved in transportation.
Article
Physics, Multidisciplinary
Qiao Lu, Deepak Bhat, Darya Stepanenko, Simone Pigolotti
Summary: The CRISPR-Cas9 system is an important gene editing tool where the key component Cas9 can search for and cleave specific target sequences on the DNA through sliding. Studies have shown that the sliding length of Cas9 is short, and the distribution of Cas9 molecules along the DNA can be rationalized through the theory of Anderson localization.
PHYSICAL REVIEW LETTERS
(2021)
Article
Chemistry, Physical
Vandana Yadav, Manoj Gopalakrishnan
Summary: The study focuses on the velocity-force relation for a Brownian ratchet in extreme limits of fast and slow barrier diffusion, deriving different V-F relations and the impact of filament number on velocity. Mean-field argument predicts equal load sharing in both limits, but different scaling behavior of velocity with filament number.
EUROPEAN PHYSICAL JOURNAL E
(2022)
Article
Biology
Deepak Bhat, Samuel Hauf, Charles Plessy, Yohei Yokobayashi, Simone Pigolotti, Armita Nourmohammad
Summary: In this study, a new method was proposed to infer the dynamics of Replisomes from DNA abundance distribution. The method was applied to measure the DNA abundance distribution in Escherichia coli populations growing at different temperatures. The results showed that the speed of Replisomes increases with temperature and exhibits wave-like variations along the genome, which correlates with the variation of mutation rate. This study provides insights into the replication dynamics of bacteria.
Article
Biochemistry & Molecular Biology
Srestha Roy, Rahul Vaippully, Muruga Lokesh, Gokul Nalupurackal, Vandana Yadav, Snigdhadev Chakraborty, Manoj Gopalakrishnan, Privita Edwina Rayappan George Edwin, Saumendra Kumar Bajpai, Basudev Roy
Summary: Conventionally, only normal cell membrane fluctuations have been studied to determine membrane properties. However, a new concept called membrane local slope fluctuations has been introduced and found to behave differently than normal fluctuations. In this study, we investigate the effect of the drug Latrunculin-B on membrane fluctuations and find that while the normal fluctuations show a power law behavior, the slope fluctuations remain constant. This provides a convenient opportunity to study membrane parameters as the membrane softens after drug application. We also explore the active athermal fluctuations in the membrane and find their timescales to be slower than 1 second.
Article
Physics, Multidisciplinary
B. Srinivas, Deepak Bhat, Manoj Gopalakrishnan
Summary: Cooperative behavior in molecular motor-cargo assembly was investigated by simulating a stochastic model, revealing the close connection between cooperative behavior and load-sharing properties.
INDIAN JOURNAL OF PHYSICS
(2022)
Article
Physics, Fluids & Plasmas
Deepak Bhat, S. Redner
Article
Physics, Multidisciplinary
Deepak Bhat, Abhishek Dhar, Anupam Kundu, Sanjib Sabhapandit
Article
Biochemistry & Molecular Biology
Balaramamahanti Srinivas, Manoj Gopalakrishnan