Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Nicolas Ecker, Karsten Kruse
Summary: The research indicates a deterministic origin of the random walk behavior in cell migration and suggests that cells can adapt their migration pattern by modifying the pool of available actin.
Article
Astronomy & Astrophysics
Jen-Tsung Hsiang, Bei-Lok Hu
Summary: This study reexamines the motion of a point charge emitting radiation in an electromagnetic field from the perspective of non-Markovian dynamics. By casting the problem as the non-Markovian dynamics of a Brownian oscillator in a supra-Ohmic environment, it is found that there is no need for a second derivative initial condition and no preacceleration.
Article
Mechanics
Linlin Kang, An-Kang Gao, Fei Han, Weicheng Cui, Xi-Yun Lu
Summary: The propulsive performance and vortex dynamics of jellyfish-like propulsion with burst-and-coast strategy are investigated using a penalty-immersed boundary method. Numerical results indicate that a significant fast-close-slow-open motion achieves higher speed, efficiency, and stability. The repulsive force induced by the strain-rate field is the main driving force of the jellyfish-like motion.
Review
Cell Biology
Jan Schick, Erez Raz
Summary: In the context of cell development, migration, and pathological conditions, cells commonly form protrusions called blebs. The inflation of blebs depends on actomyosin contraction, and they play an important role in cell locomotion. Different cells produce different forms of protrusions, with blebs being one of them.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ted Moldenhawer, Eduardo Moreno, Daniel Schindler, Sven Flemming, Matthias Holschneider, Wilhelm Huisinga, Sergio Alonso, Carsten Beta
Summary: The motility of adherent eukaryotic cells is driven by the dynamics of the actin cytoskeleton. Different cell types often show diverse modes of locomotion. Recent experiments have shown that different motility modes can be induced in mutated D. discoideum cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Chengyao Deng, Jiahao Dong, Yifei Guo, Xudong Sun, Zhongru Song, Zhenkun Li
Summary: This study proposes a core-shell structured, amoeba-like, magnetically controlled soft robot for 3D printing. The robot overcomes the limitations of existing soft robot kinematic mechanisms by using magnetically controlled smart materials and silicone materials. The printability of the magnetically controlled smart material is verified through rheological tests, and a suitable material ratio for printing is selected. The stability of the shell structures is confirmed through mechanical simulation and printing. The study also investigates the self-supporting capability of the magnetically controlled smart materials and solves the problem of phase separation between the smart material and silicone material. By leveraging the properties of magnetorheological smart materials, an integrated 3D-printed soft robot is designed and fabricated.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Multidisciplinary Sciences
Joseph d'Alessandro, Alex Barbier--Chebbah, Victor Cellerin, Olivier Benichou, Rene Marc Mege, Raphael Voituriez, Benoit Ladoux
Summary: Cells actively migrate in their environment and leave physicochemical footprints that can determine their future path. The impact of self-induced environmental perturbations on cell trajectories at different scales remains unexplored. The general coupling between motile cells and their environment can result in spatial memory of their path and change their space exploration significantly.
NATURE COMMUNICATIONS
(2021)
Article
Physics, Condensed Matter
J. Galen Wang, Roseanna N. Zia
Summary: Persistent dynamics in colloidal glasses suggest a non-equilibrium driving force for structural relaxation during glassy aging, with osmotic pressure identified as a potential driving force. Quenching a polydisperse hard-sphere colloidal liquid into the putative glass region allows for the osmotic pressure to drive redistribution of coordination number and interparticle voids, ultimately smoothing structural heterogeneity with age. Osmotic pressure plays a crucial role in driving structural rearrangements responsible for vitrification and glassy age-relaxation, with the system eventually relaxing toward a metastable state.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2021)
Article
Multidisciplinary Sciences
N. Levernier, T. Mendes, O. Benichou, R. Voituriez, T. Guerin
Summary: Persistence plays a crucial role in random processes, but calculating persistence exponents for non-Markovian systems is difficult. This study introduces a theoretical framework that determines the persistence exponents of Gaussian non-Markovian processes with non-stationary dynamics.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Camilla M. Kjeldbjerg, John F. Brady
Summary: Passive Brownian particles distribute evenly between porous medium and fluid reservoir, while active particles tend to accumulate near boundaries and preferentially partition into the porous medium. The study explores the behavior of active swimmers partitioning into a porous medium from a bulk fluid reservoir, showing oscillatory behavior at short times and steady state concentration partitioning at longer times.
Article
Chemistry, Physical
Camilla M. Kjeldbjerg, John F. Brady
Summary: Researchers have found that active Brownian particles distribute non-homogeneously near surfaces and accumulate at no-flux surfaces due to their persistent swimming. Additionally, it has been observed that two parallel plates in a dilute bath of ABPs experience a Casimir effect and attract each other.
Article
Chemistry, Physical
Tetsuro Nagai, Akira Yoshimori, Susumu Okazaki
Summary: This study investigates a series of new Monte Carlo transition probabilities that can simulate molecular trajectories satisfying the diffusion equation. The results show good agreement with the numerical solution. The method is useful for studying long-distance transport of molecules in heterogeneous systems and many-particle dynamics.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Thorsten Prustel, Martin Meier-Schellersheim
Summary: This study focused on computational models of reaction-diffusion systems commonly found in cellular signaling pathways, and introduced an approach that allows for the reconstruction of entire molecular trajectories after a simulated time step, avoiding the need for inefficient draws from non-standard distributions. This method enables highly accurate stochastic simulations for system sizes that would be prohibitively costly to simulate with conventional Green's function based methods.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Multidisciplinary Sciences
Diane-Laure Pages, Emmanuel Dornier, Jean de Seze, Emilie Gontran, Ananyo Maitra, Aurore Maciejewski, Li Wang, Rui Luan, Jerome Cartry, Charlotte Canet-Jourdan, Joel Raingeaud, Gregoire Lemahieu, Marceline Lebel, Michel Ducreux, Maximiliano Gelli, Jean-Yves Scoazec, Mathieu Coppey, Raphael Voituriez, Matthieu Piel, Fanny Jaulin
Summary: Cell migration is a fundamental process in living organisms and its deregulation is associated with cancer. This study reveals that cancer cell clusters can migrate without focal adhesions when confined into nonadhesive microfabricated channels. These clusters behave like giant super cells, mobilizing their contractility to power their migration. This collective amoeboid mode of migration could facilitate metastatic spread by allowing cells to cross various environments.
Article
Biochemistry & Molecular Biology
Munenori Ishibashi, Yukihiro Miyanaga, Satomi Matsuoka, Jun Kozuka, Yuichi Togashi, Tatsuo Kinashi, Masahiro Ueda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Multidisciplinary Sciences
Masaki Watabe, Satya N. V. Arjunan, Seiya Fukushima, Kazunari Iwamoto, Jun Kozuka, Satomi Matsuoka, Yuki Shindo, Masahiro Ueda, Koichi Takahashi
Article
Multidisciplinary Sciences
Yoichiro Kamimura, Yukihiro Miyanaga, Masahiro Ueda
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Chemistry, Multidisciplinary
Ryota Sato, Jun Kozuka, Masahiro Ueda, Reiko Mishima, Yutaro Kumagai, Akimasa Yoshimura, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Biochemistry & Molecular Biology
Michio Hiroshima, Chan-gi Pack, Kazunari Kaizu, Koichi Takahashi, Masahiro Ueda, Yasushi Sako
JOURNAL OF MOLECULAR BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Shaela Pervin, Go Itoh, Md. Shahabe Uddin Talukder, Koushiro Fujimoto, Yusuke V. Morimoto, Masamitsu Tanaka, Masahiro Ueda, Shigehiko Yumura
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Masataka Yanagawa, Michio Hiroshima, Yuichi Togashi, Mitsuhiro Abe, Takahiro Yamashita, Yoshinori Shichida, Masayuki Murata, Masahiro Ueda, Yasushi Sako
Article
Chemistry, Multidisciplinary
Akihito Komatsuzaki, Tatsuya Ohyanagi, Yoshikazu Tsukasaki, Yukihiro Miyanaga, Masahiro Ueda, Takashi Jin
Article
Multidisciplinary Sciences
Masato Yasui, Michio Hiroshima, Jun Kozuka, Yasushi Sako, Masahiro Ueda
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Takero Miyagawa, Hiroyasu Koteishi, Yoichiro Kamimura, Yukihiro Miyanaga, Kohei Takeshita, Atsushi Nakagawa, Masahiro Ueda
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Satomi Matsuoka, Masahiro Ueda
NATURE COMMUNICATIONS
(2018)
Article
Cell Biology
Haruka Hiraoka, Tadashi Nakano, Satoshi Kuwana, Masashi Fukuzawa, Yasuhiro Hirano, Masahiro Ueda, Tokuko Haraguchi, Yasushi Hiraoka
Article
Biochemistry & Molecular Biology
Naoyuki Kawase, Atsuya Sugihara, Kentaro Kajiwara, Michio Hiroshima, Kanako Akamatsu, Shigeyuki Nada, Kunio Matsumoto, Masahiro Ueda, Masato Okada
Summary: The CDCP1-SRC-ARHGEF7-RAC1 pathway plays a crucial role in HGF-induced invasion of a subset of breast cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Kazutoshi Takebayashi, Yoichiro Kamimura, Masahiro Ueda
Summary: In this study, the lateral diffusion of transmembrane proteins in Dictyostelium discoideum cells was systematically investigated. It was found that transmembrane proteins exhibited three free diffusion states with similar diffusion coefficients regardless of their structural variability. In addition, the mobility of all protein species decreased upon the inhibition of microtubule or actin cytoskeleton dynamics, or myosin II. The relationship between protein size and diffusion coefficient was consistent with the Saffman-Delbru' ck model, indicating that membrane viscosity is a major determinant of lateral diffusion.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biology
Daisuke Yoshioka, Seiya Fukushima, Hiroyasu Koteishi, Daichi Okuno, Toru Ide, Satomi Matsuoka, Masahiro Ueda
COMMUNICATIONS BIOLOGY
(2020)