Journal
PHYSICAL REVIEW E
Volume 79, Issue 4, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.79.040901
Keywords
bioelectric phenomena; cellular biophysics; diseases; Kalman filters; neurophysiology; nonlinear dynamical systems
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Funding
- NIH [R01MH50006, K02MH01493]
- Pennsylvania Keystone Innovation Zone Program and Tobacco Settlement
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Nonlinear ensemble state estimation offers a paradigm-shifting improvement in our ability to observe, predict, and control the state of spiking neuronal systems. We use an ensemble Kalman filter to predict hidden states and future trajectories in the Hodgkin-Huxley equations, reconstruct ion dynamics, control neuronal activity including a strategy for dynamic conductance clamping, and show the feasibility of controlling pathological cellular activity such as seizures.
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