☆ 4.2 Article

Genetics of Canine Primary Glaucomas

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE (2015)

Journal

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Volume 45, Issue 6, Pages 1159-+

Publisher

W B SAUNDERS CO-ELSEVIER INC

DOI: 10.1016/j.cvsm.2015.06.003

Keywords

ADAMTS10; ADAMTS17; Canine; Genetics; Glaucoma; Open-angle; Closed-angle; Lens luxation

Categories

Veterinary Sciences

Funding

Michigan State University Startup Funds
Glaucoma Research Foundation
Edward Sheppard and family
Myers-Dunlap Endowment for Canine Health

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Protocol

Community support

Reagent

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Abstract

Primary glaucomas are a leading cause of incurable vision loss in dogs. Based on their specific breed predilection, a genetic cause is suspected to be responsible, and affected dogs should be excluded from breeding. Despite the high prevalence of primary glaucomas in dogs, their genetics have been studied in only a small number of breeds. The identification of canine glaucoma disease genes, and the development of genetic tests, will help to avoid the breeding of affected dogs in the future and will allow for earlier diagnosis and potentially more effective therapy.

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