Article
Astronomy & Astrophysics
Cesar Bonilla, A. E. Carcamo Hernandez, Bastian Diaz Saez, Sergey Kovalenko, Juan Marchant Gonzalez
Summary: In this study, we propose a Majoron-like extension of the Standard Model where neutrino masses are generated through an inverse seesaw mechanism. We explore the case of Majorana fermions as dark matter candidates in this framework. Additionally, we provide parameter space regions that satisfy current experimental constraints.
Article
Physics, Particles & Fields
Asmaa Abada, Nicolas Bernal, Antonio E. Carcamo Hernandez, Xabier Marcano, Gioacchino Piazza
Summary: We propose an economical model that addresses the generation of the Inverse Seesaw mechanism from the spontaneous breaking of a local U(1)(B-L), with radiatively generated Majorana masses of sterile neutrinos from the dark sector. The model extends the field content of the Standard Model with neutral scalars and fermionic singlets, and extends the gauge group with a U(1)(B-L) and discrete Z(4) symmetries. The model complies with bounds and constraints from dark matter direct detection, invisible Higgs decays, and Z' collider searches for masses of the dark sector at the TeV scale.
EUROPEAN PHYSICAL JOURNAL C
(2021)
Article
Physics, Particles & Fields
Takaaki Nomura, Hiroshi Okada, Sudhanwa Patra
Summary: An inverse seesaw model based on right-handed fermion specific U(1) gauge symmetry and A(4)-modular symmetry is discussed, which provides predictions in the neutrino sector such as Dirac-CP phase and sum of neutrino mass. The relation among masses of heavy pseudo-Dirac neutrino can also be obtained with restrictions from the modular symmetry. Implications to lepton flavor violation and collider physics are also discussed in this model.
Article
Physics, Particles & Fields
Tobias Felkl, Adam Lackner, Michael Schmidt
Summary: In this study, we investigate whether the high-precision measurements of the cross section of the Higgsstrahlung process e(+) e(-) -> Zh at a future electron-positron collider can be used to indirectly probe the fermionic See-saw models. We consider two different centre-of-mass energies and compare the collider reaches to various constraints. We find that while the Type-I Seesaw model is strictly constrained, the Type-III Seesaw model allows for effects of up to O(10%) in the Higgsstrahlung cross section.
EUROPEAN PHYSICAL JOURNAL C
(2023)
Article
Astronomy & Astrophysics
Nobuchika Okada, Osamu Seto
Summary: We propose an extra U(1)X model with an alternative charge assignment for right-handed neutrinos. The type-II seesaw mechanism by a triplet Higgs field is promising for neutrino mass generation due to the alternative charge assignment. The small vacuum expectation value (VEV) of an additional Higgs doublet leads to a very small VEV of the triplet Higgs field, explaining the smallness of neutrino mass. Right-handed neutrinos with charge 1 in the minimal Higgs field for U(1)X are candidates for Dirac dark matter (DM) and dark radiation (DR).
Article
Physics, Particles & Fields
Joy Ganguly, Janusz Gluza, Biswajit Karmakar
Summary: The study proposes a hybrid scoto-seesaw model based on the A(4) discrete flavor symmetry, which includes at least two heavy right-handed neutrinos to mimic tribimaximal neutrino mixing and account for dark matter. Specific relative phases can distinguish between normal and inverted mass hierarchies.
JOURNAL OF HIGH ENERGY PHYSICS
(2022)
Article
Astronomy & Astrophysics
Sanjoy Mandal, Nicolas Rojas, Rahul Srivastava, Jose W. F. Valle
Summary: In this paper, a new dark sector theory related to neutrino masses is proposed within the inverse seesaw mechanism. Both explicit and dynamical lepton number violation are discussed, along with the phenomenology of dark matter and novel features associated with charged lepton flavour violation and neutrino physics.
Article
Physics, Particles & Fields
A. E. Carcamo Hernandez, D T Huong, Ivan Schmidt
Summary: In this study, we propose a renormalizable theory that utilizes the inverse seesaw mechanism to explain the pattern of SM fermion masses. Our model is the first implementation of the inverse seesaw mechanism for the charged fermion sector and successfully accounts for the observed mass hierarchy and tiny masses of light neutrinos, as well as satisfies various constraints.
EUROPEAN PHYSICAL JOURNAL C
(2022)
Article
Physics, Particles & Fields
Debasish Borah, Satyabrata Mahapatra, Narendra Sahu
Summary: In this study, low-scale seesaw scenarios within the U(1)X gauge extension of the standard model are proposed to explain the excess of electron recoil events observed by the XENON1T experiment. The model predicts stable and long-lived dark matter particles while maintaining consistency with other phenomenological bounds. The parameter space is explored for both fermion and scalar inelastic dark matter candidates, showing the potential to explain the XENON1T excess.
Article
Physics, Particles & Fields
H. B. Camara, R. G. Felipe, F. R. Joaquim
Summary: The study focuses on the minimal (2,2) inverse-seesaw model combined with Abelian flavor symmetries to achieve spontaneous CP violation, by introducing an additional scalar doublet and complex scalar singlets to the Standard Model. The CP-violating effects are successfully communicated to the lepton sector through the couplings of scalar singlets to new sterile fermions, and the active-sterile neutrino mixing is determined by active neutrino properties. Future experimental searches for heavy sterile neutrinos are discussed as well as the role of high-energy collider and beam-dump experiments in testing the model.
JOURNAL OF HIGH ENERGY PHYSICS
(2021)
Article
Astronomy & Astrophysics
A. E. Carcamo Hernandez, Sergey Kovalenko, Farinaldo S. Queiroz, Yoxara S. Villamizar
Summary: In this paper, a model based on the SU (3)(C) x SU (3)(L) x U(1)(X) (3-3-1) gauge symmetry is proposed to explain the recent measurements of the muon anomalous magnetic moment (g-2) and nonzero neutrino masses. By introducing right-handed neutrinos and vector-like fermions, the model successfully explains the active neutrino masses and reproduces the recent Muon g(-2) results within the existing bounds.
Article
Astronomy & Astrophysics
Hajime Otsuka, Takashi Shimomura, Koji Tsumura, Yoshiki Uchida, Naoki Yamatsu
Summary: We propose a pseudo-Nambu-Goldstone boson dark matter model based on an additional non-Abelian gauge symmetry. The model suggests that the lightest charged particle becomes stable due to the exact global symmetry, avoiding strong constraints from current DM direct detection experiments. The measured energy density of DM can be reproduced when the DM mass is larger than half of the Higgs mass.
Article
Physics, Nuclear
V. V. Vien
Summary: This article proposes a low-scale Standard Model extension with specific symmetries that can explain observed neutrino oscillation results and provides predictions for neutrino mass ordering, lepton mixing angles, and phases, which are consistent with experimental results.
Article
Physics, Multidisciplinary
Nayana Gautam, R. Krishnan, Mrinal Kumar Das
Summary: In this study, we investigated the impact of sterile neutrinos on low-scale processes within the framework of the minimal extended seesaw (MES) model based on Delta(96) x C (2) x C (3) flavor symmetry. The model predicts the maximal value of the Dirac CP phase and normal ordering (NO) of neutrino masses. Our analysis suggests that a heavy sterile neutrino can contribute to charged lepton flavor violation (cLFV) processes that are detectable by current and upcoming experiments, while remaining consistent with the limits set by neutrinoless double beta decay (0 nu beta beta) experiments.
FRONTIERS IN PHYSICS
(2021)
Article
Astronomy & Astrophysics
Di Zhang, Shun Zhou
Summary: The canonical type-I seesaw model discusses the generation of Majorana neutrino masses and unitarity violation of lepton flavor mixing. By calculating the Wilson coefficients through one-loop matching, the total rates of radiative decays of charged leptons have been successfully computed.
Article
Endocrinology & Metabolism
Chihiro Munekawa, Hiroshi Okada, Masahide Hamaguchi, Momoko Habu, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study found that the risk of developing type 2 diabetes among individuals with a fasting plasma glucose concentration of 90-99 mg/dL increased progressively with higher levels of fasting plasma glucose concentration in the Japanese population.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Nutrition & Dietetics
Yoshitaka Hashimoto, Fuyuko Takahashi, Ayumi Kaji, Ryosuke Sakai, Takuro Okamura, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui
Summary: This study aimed to investigate the relationship between eating speed and the presence of sarcopenia in older patients with type 2 diabetes (T2D). The results showed that patients with a slow eating speed had a higher risk of low skeletal muscle mass, low muscle strength, and sarcopenia compared to those with a fast or normal eating speed.
Article
Environmental Sciences
Yuto Saijo, Hiroshi Okada, Masahide Hamaguchi, Momoko Habu, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study found significant differences in risk factors for developing type 2 diabetes between different BMI categories in a Japanese population. The risk factors were different for individuals with BMI < 22 kg/m(2) compared to those with 22 <= BMI < 25 kg/m(2) or BMI >= 25 kg/m(2).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Keiko Iwai, Emi Ushigome, Kazufumi Okada, Isao Yokota, Saori Majima, Naoko Nakanishi, Yoshitaka Hashimoto, Hiroshi Okada, Takafumi Senmaru, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: This study aimed to investigate the effects of aerobic exercise on home blood pressure in patients with diabetes. The results showed that moderate aerobic exercise was not effective in lowering nocturnal blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hanako Nakajima, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: The aim of this study was to determine the cut-off values of liver enzymes to identify the risk of type 2 diabetes and to investigate the association between liver enzymes and incident diabetes among individuals with or without obesity. The findings showed that individuals with ALT >= 23 or AST/ALT <= 0.875 and BMI >= 25 kg/m(2) had a higher risk of developing diabetes.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Cell Biology
Takuro Okamura, Masahide Hamaguchi, Hiroyuki Tominaga, Noriyuki Kitagawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Shigeyuki Shichino, Michiaki Fukui
Summary: This study found differences in TCR sequences and gene expression of CD8(+) and FOXP3(+) cells between patients with type 1 diabetes mellitus (T1DM) and healthy subjects.
Correction
Endocrinology & Metabolism
K. Iwai, E. Ushigome, I Yokota
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Yukiko Kobayashi, Ayumi Kaji, Ryosuke Sakai, Takuro Okamura, Naoko Nakanishi, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Wataru Aoi, Masashi Kuwahata, Michiaki Fukui
Summary: This study showed that household income was related to dietary fiber intake and dietary acid load in men but not in women.
Article
Endocrinology & Metabolism
Ayaka Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study found that the stable, metabolically healthy nonobesity group had a lower risk of incident type 2 diabetes compared to the stable, metabolically healthy obesity group. When metabolically healthy obese individuals changed to metabolically healthy nonobese status, their risk of developing type 2 diabetes was similar to that of participants in the stable metabolically healthy nonobesity group. These findings suggest the importance of paying attention to changes in metabolic phenotypes to prevent incident type 2 diabetes in the Japanese population.
Article
Endocrinology & Metabolism
Takahiro Ichikawa, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study aimed to investigate the association between estimated small dense low-density lipoprotein (sdLDL) and incident type 2 diabetes. Data from a health checkup program conducted by Panasonic Corporation between 2008 and 2018 were analyzed. The study found that estimated sdLDL cholesterol was an important predictor of future incidence of diabetes within 10 years and had a higher area under the curve compared to other lipid profiles.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Nutrition & Dietetics
Genki Kobayashi, Takuro Okamura, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Yuichiro Nishimoto, Takuji Yamada, Hideto Okamoto, Nobuaki Okumura, Ryoichi Sasano, Masahide Hamaguchi, Michiaki Fukui
Summary: This study focused on the therapeutic efficacy of medium-chain fatty acids (MCFAs), unique to royal jelly (RJ), in treating non-alcoholic fatty liver disease (NAFLD). Results showed that RJ improved NAFLD activity scores and decreased gene expression related to fatty acid metabolism, fibrosis, and inflammation in the liver. RJ also regulated innate immunity-related inflammatory responses in the small intestine and decreased the expression of genes associated with inflammation and nutrient absorption transporters. RJ increased the abundance of certain bacteria that produce short-chain fatty acids and increased the concentrations of RJ-related MCFAs in the serum and liver. These MCFAs decreased saturated fatty acid deposition in liver cells and decreased the gene expression associated with fibrosis and fatty acid metabolism. RJ and RJ-related MCFAs improved dysbiosis and regulated the expression of inflammation-, fibrosis-, and nutrient absorption transporter-related genes, thereby preventing NAFLD.
Article
Nutrition & Dietetics
Hanako Nakajima, Hiroshi Okada, Ayaka Kobayashi, Fuyuko Takahashi, Takuro Okamura, Yoshitaka Hashimoto, Naoko Nakanishi, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to identify the serum metabolites associated with sarcopenic risk in Japanese patients with type 2 diabetes. The relationship between dietary protein intake and the metabolites concerning sarcopenia was analyzed, and the factors affecting sarcopenic risk were clarified. Leucine and glutamic acid were found to be useful biomarkers for sarcopenia.
Review
Cardiac & Cardiovascular Systems
Kimiko Sakai, Hiroshi Okada, Masahide Hamaguchi, Norihiro Nishioka, Yukiko Tateyama, Tomonari Shimamoto, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Taku Iwami, Michiaki Fukui
Summary: This retrospective cohort study aimed to investigate the association between diet behaviors and incident cardiovascular disease (CVD) in Japanese individuals. The results showed that skipping breakfast and fast eating were associated with the occurrence of cardiovascular events, especially in individuals with a BMI below 25.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hanako Nakajima, Hiroshi Okada, Yuta Yoshimura, Toru Tanaka, Goji Hasegawa, Kazuteru Mitsuhashi, Noriyuki Kitagawa, Takuro Okamura, Yoshitaka Hashimoto, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahiro Yamazaki, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to evaluate the risk of ketosis in individuals with type 1 diabetes taking SGLT2 inhibitors, and to investigate the relationship between nutritional assessment, glycemic status, CPR index, and body composition. The results showed that younger age and a low ratio of basal to bolus insulin were associated with an increased risk of ketosis after taking SGLT2 inhibitors.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Junya Hironaka, Hiroshi Okada, Masahide Hamaguchi, Kimiko Sakai, Megumi Minamida, Yuriko Kondo, Yoshitaka Hashimoto, Noriyuki Kitagawa, Miho Yano, Masahiro Yamazaki, Goji Hasegawa, Go Horiguchi, Satoshi Teramukai, Michiaki Fukui
Summary: This study aimed to investigate the effects of dapagliflozin on the renal function of type 1 diabetes patients. The results showed that after 24 months of dapagliflozin treatment, the decrease in estimated glomerular filtration rate (eGFR) was significantly smaller compared to the non-use group. Additionally, the dapagliflozin group also had lower levels of HbA1c, insulin dosage, and urinary albumin-to-creatinine ratio (UACR) changes compared to the non-use group.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)