Article
Physics, Nuclear
O. Klochko, N. A. Smirnova
Summary: Using a macroscopic-microscopic approach, this study examines the coefficients of the isobaric-multiplet mass equation (IMME), particularly focusing on the a, b, and c coefficients. The research finds that the macroscopic part of the finite-range liquid-drop model (FRLDM) adequately captures the trends of the a and b coefficients, while the behavior of b coefficients for doublets and quartets can be explained by differences in average proton and neutron pairing energies. Predictions based on full macroscopic-microscopic approaches provide insights into the general trends of IMME coefficients up to A = 100, with satisfactory agreement for a coefficients but less sensitivity for predicting b and c coefficients in detail.
Article
Physics, Nuclear
Hong-Fu Li, Xing Xu, Meng Wang, Yu-Hu Zhang, Chao-Yi Fu, Wen-Jia Huang
Summary: By using the ground-state mass of Ni-52 and the two-proton decay energy of Zn-54, the ground-state mass excess of (54)Zn is determined, which is lower than the prediction of the quadratic form of the isobaric multiplet mass equation (IMME). The cubic fit analysis of the mass data for the A = 54, T = 3 isospin multiplet shows a significantly large d coefficient of IMME and a deviation in the b/c ratio. This study suggests that the breakdown of the quadratic form of IMME could be caused by the mis-assignment of the T = 3 isobaric analog state (IAS) in the T-z = 1 nucleus Fe-54 or strong isospin mixing.
Article
Chemistry, Analytical
Yiran Liang, Thy Truong, Aubrianna J. Saxton, Hannah Boekweg, Samuel H. Payne, Pam M. Van Ry, Ryan T. Kelly
Summary: Recent advances in mass spectrometry-based single-cell proteomics have improved sensitivity, but measurement throughput is still limited. To increase throughput, we combined isobaric and isotopic labeling methods for multiplexing. By using SILAC and TMT labeling, we were able to analyze up to 28 single cells in a single LC-MS analysis. With a customized nanowell chip, sample losses were minimized. The measurement throughput could be further increased with a high-duty-cycle multicolumn LC system.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Jonathon J. O'Brien, Anil Raj, Aleksandr Gaun, Adam Waite, Wenzhou Li, David G. Hendrickson, Niclas Olsson, Fiona E. McAllister
Summary: This study presents a framework for analyzing multiplexed mass spectrometry proteomics data that reduces estimation error when combining multiple isobaric batches. The framework improves the power to detect statistical associations and increases quantitative proteome coverage by accounting for variations in the number and quality of observations across batches.
Article
Chemistry, Analytical
Ahmed Ben Faleh, Stephan Warnke, Teun Van Wieringen, Ali H. Abikhodr, Thomas R. Rizzo
Summary: The combination of high-resolution ion mobility spectrometry and cryogenic vibrational spectroscopy offers a rapid and efficient method for separating and identifying isomeric and isobaric metabolites. Ion mobility enables the separation of isomers in milliseconds, while cryogenic IR spectroscopy provides clear IR fingerprints for molecular identification. Additionally, our approach allows for automatic identification of metabolite isomers by comparing their IR fingerprints with those in a database, eliminating the need for analytical standards. We demonstrate the principle of this approach by constructing a database of IR fingerprints for eight isomeric/isobaric metabolites and using it for identification in mixtures. Furthermore, our fast IR fingerprinting technology allows for rapid probing of IR fingerprints as molecules elute from an LC column. This approach has great potential to enhance metabolomics workflows in terms of accuracy, speed, and cost.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Michael R. Armbruster, Scott F. Grady, Rhea N. Caldwell, Christopher K. Arnatt, James L. Edwards
Summary: This article presents a new method for generating constant mass reporters using a dual fragmentation scheme.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Review
Genetics & Heredity
Xiulan Chen, Yaping Sun, Tingting Zhang, Lian Shu, Peter Roepstorff, Fuquan Yang
Summary: Isobaric labeling technology has become a key tool for comparing protein expression in biological samples, although challenges remain in terms of quantitative accuracy and precision. The different types of isobaric mass tags and advantages and disadvantages of the labeling method are detailed, along with precautions needed at each step of the workflow for reliable quantification results. The broad applications of isobaric labeling technology in biological and clinical studies, with a focus on thermal proteome profiling and proteogenomics, are also discussed.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Chemistry, Analytical
Min Ma, Miyang Li, Yinlong Zhu, Yingyi Zhao, Feixuan Wu, Zicong Wang, Yu Feng, Hung-Yu Chiang, Manish S. Patankar, Cheng Chang, Lingjun Li
Summary: This study introduces a new method, called MAGNI, for multiplexed, quantitative, and targeted glycan analysis. By using isobaric-labeling and ultrahigh-resolution mass spectrometers, low-abundance glycans can be recognized and provide rich information on glycan structures. Using this method, a large number of unique N-glycans were identified in two ovarian cancer cell lines, revealing differences in glycosylation patterns between cell lines.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Danqing Wang, Min Ma, Junfeng Huang, Yusi Cui, Ting-Jia Gu, Miyang Li, Zicong Wang, Henrik Zetterberg, Lingjun Li
Summary: An improved isobaric labeling strategy, Boost-DiLeu, was developed to enhance the quantitative glycoproteomic analysis, allowing reliable quantification of N-glycopeptides even from limited samples. The strategy was applied to differentiate N-glycosylation profiles between Alzheimer's disease patients and non-AD donors, revealing dysregulated processes and pathways affected by N-glycosylation in AD pathogenesis. The study demonstrated the feasibility of using this strategy for in-depth glycoproteomic analysis of size-limited clinical samples, showing promise for identifying novel therapeutic targets or biomarkers in systems with limited sample quantity.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuri L. L. Mikhlin, Roman V. V. Borisov, Maxim N. N. Likhatski, Oleg A. A. Bayukov, Yuriy V. V. Knyazev, Sergey M. M. Zharkov, Sergey A. A. Vorobyev, Yevgeny V. V. Tomashevich, Anastasiya D. D. Ivaneeva, Anton A. A. Karacharov, Denis V. V. Karpov, Dmitriy A. A. Velikanov, Mikhail V. V. Rautskii, Dmitry A. A. Smolyakov, Anton S. S. Tarasov
Summary: We have developed a simple hydrothermal synthesis method to fabricate 100-200 nm flakes of tochilinite (Fe1-xS)center dot n(Mg,Fe)(OH)(2), which serve as a representative of multifunctional two-dimensional materials. The formation of the flakes was ensured by using excess sodium sulfide and driven by the opposite electric charges of metal sulfide and hydroxide sheets. The characterization results show the presence of Fe3+ cations in the hydroxide layers, which can be tuned by adding Al and Li, while the Fe1-xS sheets contain high-spin Fe3+ and Fe2+ centers, as well as some S-S bonding.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Roderick Corstiaan Abraham Versloot, Patricia Arias-Orozco, Matthijs Jonathan Tadema, Florian Leonardus Rudolfus Lucas, Xinghong Zhao, Siewert J. J. Marrink, Oscar Paul Kuipers, Giovanni Maglia
Summary: Mass spectrometry cannot distinguish between molecules with the same mass-to-charge ratio, but nanopore technology can differentiate diastereomeric and enantiomeric differences in peptides that cannot be observed by conventional MS analysis. The resolution in nanopore analysis is likely due to multiple chiral interactions during peptide transport across the nanopore, similar to chiral chromatography. Nanopore technology also offers possibilities for the rapid and cost-effective analysis of peptides, including those that cannot be easily differentiated by mass spectrometry.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Astronomy & Astrophysics
Lu-Meng Liu, Chun-Jian Zhang, Jia Zhou, Jun Xu, Jiangyong Jia, Guang-Xiong Peng
Summary: We demonstrate that the yield ratio of free spectator neutrons in high-energy collisions of Zr-96+Zr-96 and Ru-96+Ru-96 nuclei can be used as a clean tool to investigate the neutron-skin thickness and the slope parameter L of the symmetry energy. We use a state-of-the-art Skyrme-Hartree-Fock-Bogolyubov calculation to analyze the proton and neutron density distributions. The production of free spectator neutrons is not affected by the dynamics in the mid-rapidity region, making the ratio of their multiplicities in ultracentral isobaric collisions a robust observable for constraining the neutron skin and L value.
Article
Chemistry, Physical
Zufar Zaripov, Ruslan R. Nakipov, Farid M. Gumerov, Ilmutdin M. Abdulagatov
Summary: The isobaric heat capacity of hexadecane was measured using a differential scanning calorimeter, and the second temperature derivatives of specific volume, enthalpy, and entropy as a function of temperature and pressure were calculated.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Analytical
Jan Leipert, Max K. Steinbach, Andreas Tholey
Summary: Digital microfluidics (DMF) is a technology suitable for miniaturized, automated, and multiplexed liquid handling in bioanalytical applications. While its use in LC-MS-based proteomics has been limited to qualitative analyses, the implementation of isobaric peptide labeling on DMF devices has shown promise, especially with the use of maltoside-based detergents. This detergent enables facile droplet movement and is compatible with organic solvents, allowing for efficient isobaric tandem mass tag (TMT) labeling. The newly developed labeling protocol has been successfully applied to multiplexed proteome studies, showing promise for high throughput low cell number proteomics.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Kenneth W. Lee, Trenton M. Peters-Clarke, Keaton L. Mertz, Graeme C. McAlister, John E. P. Syka, Michael S. Westphall, Joshua J. Coon
Summary: Isobaric tagging enables the determination of peptide sequences and relative amounts in biological samples. However, limited generation of reporter ions and unintended fragmentation can affect quantitative accuracy. In this study, we used infrared photon activation and ion parking to increase reporter ion yield. Additionally, we showed that using infrared multiphoton dissociation to generate reporter ions from multiple synchronously isolated peptide product ions significantly enhances sensitivity and dynamic range of quantitation via isobaric tagging.
ANALYTICAL CHEMISTRY
(2022)
Article
Astronomy & Astrophysics
G. Jhang, J. Estee, J. Barney, G. Cerizza, M. Kaneko, J. W. Lee, W. G. Lynch, T. Isobe, M. Kurata-Nishimura, T. Murakami, C. Y. Tsang, M. B. Tsang, R. Wang, D. S. Ahn, L. Atar, T. Aumann, H. Baba, K. Boretzky, J. Brzychczyk, N. Chiga, N. Fukuda, I Gasparic, B. Hong, A. Horvat, K. Ieki, N. Inabe, Y. J. Kim, T. Kobayashi, Y. Kondo, P. Lasko, H. S. Lee, Y. Leifels, J. Lukasik, J. Manfredi, A. B. McIntosh, P. Morfouace, T. Nakamura, N. Nakatsuka, S. Nishimura, R. Olsen, H. Otsu, P. Pawlowski, K. Pelczar, D. Rossi, H. Sakurai, C. Santamaria, H. Sato, H. Scheit, R. Shane, Y. Shimizu, H. Simon, A. Snoch, A. Sochocka, Z. Sosin, T. Sumikama, H. Suzuki, D. Suzuki, H. Takeda, S. Tangwancharoen, H. Toernqvist, Y. Togano, Z. G. Xiao, S. J. Yennello, J. Yurkon, Y. Zhang, Maria Colonna, Dan Cozma, Pawel Danielewicz, Hannah Elfner, Natsumi Ikeno, Che Ming Ko, Justin Mohs, Dmytro Oliinychenko, Akira Ono, Jun Su, Yong Jia Wang, Hermann Wolter, Jun Xu, Ying-Xun Zhang, Zhen Zhang
Summary: A new experiment studying the symmetry energy measured the multiplicities of negatively and positively charged pions generated in heavy ion collisions, but found that the differences among transport codes prevent the extraction of reliable constraints on the symmetry energy from the data.
Article
Instruments & Instrumentation
A. Galindo-Tellez, K. Keefe, E. Adamek, E. Brubaker, B. Crow, R. Dorrill, A. Druetzler, C. J. Felix, N. Kaneshige, J. G. Learned, J. J. Manfredi, K. Nishimura, B. Pinto Souza, D. Schoen, M. Sweany
Summary: The Optically Segmented Single Volume Scatter Camera (OS-SVSC) is designed to image neutron sources using the kinematic reconstruction of elastic double-scatter events for non-proliferation applications. The prototype system consists of organic plastic scintillator bars optically coupled to silicon photomultiplier arrays to achieve high energy and position calibration precision.
JOURNAL OF INSTRUMENTATION
(2021)
Article
Physics, Multidisciplinary
R. J. Charity, T. B. Webb, J. M. Elson, D. E. M. Hoff, C. D. Pruitt, L. G. Sobotka, K. W. Brown, G. Cerizza, J. Estee, W. G. Lynch, J. Manfredi, P. Morfouace, C. Santamaria, S. Sweany, C. Y. Tsang, M. B. Tsang, Y. Zhang, K. Zhu, S. A. Kuvin, D. McNeel, J. Smith, A. H. Wuosmaa, Z. Chajecki
Summary: A F-13 resonance was observed following a charge-exchange reaction between a fast O-13 beam and a Be-9 target, corresponding to a 5/2(+) excited state. The observed level decays via initial proton emissions to both the ground and first 2(+) state of O-12, with possibly a significant proton decay branch to the second 2(+) level in O-12. The wave function associated with the observed level may be collectivized due to coupling to the continuum above the threshold for proton decay to the 2(2)(+) state of O-12.
PHYSICAL REVIEW LETTERS
(2021)
Article
Physics, Multidisciplinary
J. Estee, W. G. Lynch, C. Y. Tsang, J. Barney, G. Jhang, M. B. Tsang, R. Wang, M. Kaneko, J. W. Lee, T. Isobe, M. Kurata-Nishimura, T. Murakami, D. S. Ahn, L. Atar, T. Aumann, H. Baba, K. Boretzky, J. Brzychczyk, G. Cerizza, N. Chiga, N. Fukuda, I Gasparic, B. Hong, A. Horvat, K. Ieki, N. Inabe, Y. J. Kim, T. Kobayashi, Y. Kondo, P. Lasko, H. S. Lee, Y. Leifels, J. Lukasik, J. Manfredi, A. B. McIntosh, P. Morfouace, T. Nakamura, N. Nakatsuka, S. Nishimura, H. Otsu, P. Pawlowski, K. Pelczar, D. Rossi, H. Sakurai, C. Santamaria, H. Sato, H. Scheit, R. Shane, Y. Shimizu, H. Simon, A. Snoch, A. Sochocka, T. Sumikama, H. Suzuki, D. Suzuki, H. Takeda, S. Tangwancharoen, H. Toernqvist, Y. Togano, Z. G. Xiao, S. J. Yennello, Y. Zhang, M. D. Cozma
Summary: By measuring the ratio of charged pion spectra at high transverse momenta, we deduced the slope of the symmetry energy to be 42 < L < 117 MeV, which is slightly lower but consistent with the L values deduced from a recent measurement of the neutron skin thickness of Pb-208.
PHYSICAL REVIEW LETTERS
(2021)
Article
Instruments & Instrumentation
S. Sweany, W. G. Lynch, K. Brown, A. Anthony, Z. Chajecki, D. Dell'Aquila, P. Morfouace, F. C. E. Teh, C. Y. Tsang, M. B. Tsang, R. S. Wang, K. Zhu
Summary: Efficient detection of energetic light charged particles often involves using arrays of energy-loss telescopes with two or more layers of detection media. This study develops a method for measuring corrections and determines reaction and out-scattering losses for silicon-CsI(Tl) telescopes of the newly developed HiRA10 array, with extracted efficiencies in good agreement with model predictions.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2021)
Article
Physics, Nuclear
C. Hebborn, F. M. Nunes, G. Potel, W. H. Dickhoff, J. W. Holt, M. C. Atkinson, R. B. Baker, C. Barbieri, G. Blanchon, M. Burrows, R. Capote, P. Danielewicz, M. Dupuis, Ch Elster, J. E. Escher, L. Hlophe, A. Idini, H. Jayatissa, B. P. Kay, K. Kravvaris, J. J. Manfredi, A. Mercenne, B. Morillon, G. Perdikakis, C. D. Pruitt, G. H. Sargsyan, I. J. Thompson, M. Vorabbi, T. R. Whitehead
Summary: We review recent progress in nuclear optical potentials and emphasize the need for further developments, especially in regions away from stability. An improved description of nuclear reactions involving short-lived isotopes has significant benefits for fundamental science discoveries and applications. We outline the methods used to build optical potentials and discuss the strengths and weaknesses of each approach. We also provide open challenges and recommendations to advance nuclear reaction studies in the rare-isotope beam era.
JOURNAL OF PHYSICS G-NUCLEAR AND PARTICLE PHYSICS
(2023)
Article
Instruments & Instrumentation
Tyler D. Dolezal, Juan J. Manfredi, Brian G. Frandsen, James E. Bevins, Connor Gautam, Theodore W. Stephens, Thomas Ruland, Michael T. Febbraro
Summary: A novel fast-cured, boron-loaded, plastic organic scintillator was developed and characterized. The scintillator was manufactured quickly by adding commercially available fast-curing monomers, isobornyl acrylate and 1,6-Hexanediol dimethacrylate. The device showed good performance with a light yield of approximately 70% compared to an aged EJ-276 detector, and higher light output for neutron capture.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2023)
Article
Instruments & Instrumentation
J. A. Brown, T. A. Laplace, B. L. Goldblum, J. J. Manfredi, T. S. Johnson, F. Moretti, A. Venkatraman
Summary: This study evaluates the suitability of the EJ-204 plastic scintillator as a reference standard for measuring the absolute light yield of organic scintillators. The results show that the absolute light yield of the fresh samples is lower than the manufacturer-reported value, and the aged samples have significantly lower light yields. These findings suggest caution should be exercised when using plastic scintillators in photon counting applications.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2023)
Article
Physics, Particles & Fields
E. J. Callaghan, B. L. Goldblum, J. A. Brown, T. A. Laplace, J. J. Manfredi, M. Yeh, G. D. Orebi Gann
Summary: This study presents the first measurement of the proton light yield of a water-based liquid scintillator (WbLS) and a pure LAB + 2 g/L 2,5-diphenyloxazole (PPO) mixture (LABPPO). The proton light yields were measured using a double time-of-flight method and a pulsed neutron beam. The results show that the proton light yield of WbLS is approximately 3.8% lower than that of LABPPO, which itself exhibits a relative proton light yield 15-20% higher than previous measurements of a similar sample.
EUROPEAN PHYSICAL JOURNAL C
(2023)
Article
Physics, Nuclear
J. W. Lee, M. B. Tsang, C. Y. Tsang, R. Wang, J. Barney, J. Estee, T. Isobe, M. Kaneko, M. Kurata-Nishimura, W. G. Lynch, T. Murakami, A. Ono, S. R. Souza, D. S. Ahn, L. Atar, T. Aumann, H. Baba, K. Boretzky, J. Brzychczyk, G. Cerizza, N. Chiga, N. Fukuda, I Gasparic, B. Hong, A. Horvat, K. Ieki, N. Ikeno, N. Inabe, G. Jhang, Y. J. Kim, T. Kobayashi, Y. Kondo, P. Lasko, H. S. Lee, Y. Leifels, J. Lukasik, J. Manfredi, A. B. McIntosh, P. Morfouace, T. Nakamura, N. Nakatsuka, S. Nishimura, H. Otsu, P. Pawlowski, K. Pelczar, D. Rossi, H. Sakurai, C. Santamaria, H. Sato, H. Scheit, R. Shane, Y. Shimizu, H. Simon, A. Snoch, A. Sochocka, T. Sumikama, H. Suzuki, D. Suzuki, H. Takeda, S. Tangwancharoen, Y. Togano, Z. G. Xiao, S. J. Yennello, Y. Zhang
Summary: Experimental information on fragment emissions is important for understanding nuclear collision dynamics and developing transport models. The hypothesis of thermal equilibrium breaks down for particles emitted with high transfer momentum. The scaling features of particle yield ratios from two systems are examined to investigate the system's properties, and the breakdown of isoscaling for high transverse momentum particles cannot be explained by the antisymmetrized molecular dynamics model.
EUROPEAN PHYSICAL JOURNAL A
(2022)
Article
Materials Science, Multidisciplinary
Thibault A. Laplace, Bethany L. Goldblu, Joshua A. Brown, Glenn LeBlanc, Tianyue Li, Juan J. Manfredi, Erik Brubaker
Summary: This study evaluates the light yield data of protons and carbon ions in organic scintillators using ionization quenching models. The results show that the existing models can reasonably describe the light yield of protons within a specific energy range, but additional research is needed for carbon ions. This study is important for accurately modeling scintillator-based neutron detection systems.
MATERIALS ADVANCES
(2022)
Article
Physics, Nuclear
R. J. Charity, T. B. Webb, J. M. Elson, D. E. M. Hoff, C. D. Pruitt, L. G. Sobotka, P. Navratil, G. Hupin, K. Kravvaris, S. Quaglioni, K. W. Brown, G. Cerizza, J. Estee, W. G. Lynch, J. Manfredi, P. Morfouace, C. Santamaria, S. Sweany, M. B. Tsang, T. Tsang, K. Zhu, S. A. Kuvin, D. McNeel, J. Smith, A. H. Wuosmaa, Z. Chajecki
Summary: Excited states in O-13 were studied via inelastic scattering, identifying proton emission characteristics and comparing with computational models, revealing new spin states. These findings have wide applications for spin assignments.
Article
Physics, Nuclear
J. Manfredi, J. Lee, A. M. Rogers, M. B. Tsang, W. G. Lynch, C. Anderson, J. Barney, K. W. Brown, B. Brophy, G. Cerizza, Z. Chajecki, G. Chen, J. Elson, J. Estee, H. Iwasaki, C. Langer, Z. Li, C. Loelius, C. Y. Niu, C. Pruitt, H. Setiawan, R. Showalter, K. Smith, L. G. Sobotka, S. Sweany, S. Tangwancharoen, J. R. Winkelbauer, Z. Xiao, Z. Xu
Summary: The extracted spectroscopic factors from transfer reactions in this study are consistent with previous measurements, supporting the reliability of transfer reactions as a probe for the nuclear structure of exotic nuclei. This suggests a much weaker asymmetry dependence in transfer reactions compared to single-nucleon knockout reactions on beryllium or carbon targets, as indicated by a large body of experimental and theoretical studies.
Article
Physics, Nuclear
T. A. Laplace, B. L. Goldblum, J. J. Manfredi, J. A. Brown, D. L. Bleuel, C. A. Brand, G. Gabella, J. Gordon, E. Brubaker
Summary: This study presents a new approach for simultaneously measuring the proton and carbon light yield of organic scintillators, providing new carbon light yield data for EJ-309 liquid and EJ-204 plastic organic scintillators. The results offer new insight into the ionization quenching effect in organic scintillators and provide key input for the simulation of organic scintillator responses in various applications.
