Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 15, Issue 33, Pages 13723-13736Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cp51761f
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Funding
- Fundacao para a Ciencia e a Tecnologia, Portugal [SFRH/BD/28269/2006, POCTI/BIO/57193/2004, PEst-OE/EQB/LA0004/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/28269/2006] Funding Source: FCT
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The technological value of nonaqueous enzymology has been recognized for more than thirty years. A detailed understanding of the molecular determinants of enzyme behaviour in nonaqueous media is essential to explore their potential. Computer simulations have provided valuable contributions to this field, having elucidated how the solvent affects the structural and dynamic properties of enzymes, as well as their activity and enantioselectivity. They have also helped to shed light on the effect of hydration and the role of counterions. In this perspective, we describe the major challenges and achievements of molecular simulations of enzymes in different types of nonaqueous solvents, including organic solvents, ionic liquids and supercritical fluids.
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