Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 15, Issue 15, Pages 5386-5394Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cp42044a
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Funding
- ANPCyT [PICT 2010-070, PICT 2011-1249]
- UBA [UBACYT 20020090100094]
- CONICET
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The study of proteins immobilized on biomimetic or biocompatible electrodes represents an active field of research as it pursues both fundamental and technological interests. In this context, adsorption and redox properties of cytochrome c (Cyt) on different electrode surfaces have been extensively reported, although in some cases with contradictory results. Here we report a SERR spectroelectrochemical study of the adsorption and electron transfer behaviour of the basic protein Cyt on electrodes coated with amino-terminated monolayers. The obtained results show that inorganic phosphate (Pi) and ATP anions are able to mediate high affinity binding of the protein with preservation of the native structure and rendering an average orientation that guarantees efficient pathways for direct electron transfer. These findings aid the design of Cyt-based bioelectronic devices and understanding the modulation by Pi and ATP of physiological functions of Cyt.
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