Review
Biochemistry & Molecular Biology
Nicolas Papadopoulos, Nuria Suelves, Florian Perrin, Devkee M. Vadukul, Celine Vrancx, Stefan N. Constantinescu, Pascal Kienlen-Campard
Summary: Most neurodegenerative diseases are characterized by protein folding disorders, such as Alzheimer's disease. These diseases lead to the appearance of protein aggregates in vulnerable regions of the nervous system, which progressively spread through the neuronal network. Alzheimer's disease is characterized by neurofibrillary tangles composed of tau proteins and senile plaques composed of amyloid peptides. Understanding the structural determinants of the precursor protein APP and the formation of different A beta aggregates is crucial in deciphering the pathological conformational changes and mechanisms underlying amyloid fibril formation.
Article
Neurosciences
Carolin Hofmann, Annika Sander, Xing Xing Wang, Martina Buerge, Bettina Jungwirth, Laura Borgstedt, Matthias Kreuzer, Claudia Kopp, Kenji Schorpp, Kamyar Hadian, Carsten T. Wotjak, Tim Ebert, Maarten Ruitenberg, Christopher G. Parsons, Gerhard Rammes
Summary: The study found that xenon has a slowing effect on Aβ aggregation, as well as positive impacts on LTP and spine density. Isoflurane and sevoflurane did not exacerbate the AD pathology caused by Aβ, but they did impact neuronal activity in vitro.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Environmental Sciences
Lingling Wang, Enjun Xia, Zixiang Wei, Wei Wang
Summary: This study aims to capture the key driving forces that affect the sustainable energy-water development characteristics in Chinese change processes throughout 2000-2017. The manufacturing and construction sectors are the largest and lowest energy consumers, while agriculture accounts for the largest share in water use. The GDP value-added effect, income improvement effect, and population-scale effect increase the energy-water use, while the intensity effect plays a vital role in decreasing energy-water use during the study period.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Physical
Moe Yamazaki, Keisuke Ikeda, Tomoshi Kameda, Hiroyuki Nakao, Minoru Nakano
Summary: This study investigates the kinetic mechanism of amyloid fibril formation by a peptide fragment containing seven residues of the amyloid-beta protein Aβ-(16-22). The results show that the unprotected peptide fragment can rapidly form fibrils in a neutral aqueous buffer solution, and the fibrillation kinetics can be described by the nucleation-elongation model. The width of the fibrils increases over time, possibly due to lateral association. Electrostatic and hydrophobic interactions play important roles in the fibrillation process.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Dusan Mrdenovic, Piotr Zarzycki, Marta Majewska, Izabela S. Pieta, Robert Nowakowski, Wlodzimierz Kutner, Jacek Lipkowski, Piotr Pieta
Summary: K162 inhibits the permeation of A beta Os-induced BLM, preserving BLM integrity. It modifies A beta aggregation by bypassing the formation of toxic A beta Os, producing only nontoxic A beta Ms, dimers, and fibrils. This unique mechanism may offer a new therapeutic strategy for AD.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Green & Sustainable Science & Technology
Fan Yu, Yuan Wang, Xin Liu, Jinru Yu, Dandan Zhao, Haijun Deng, Bin Guo, Rui Shi, Bowei Wu, Huayang Chen
Summary: The COVID-19 outbreak has had a detrimental impact on the global industrial supply chain, especially in China. Fujian Province, as a major processing hub for imported materials, has been significantly affected. However, the lockdown measures have also had some positive effects on the global ecology.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Multidisciplinary
Takahiro Watanabe-Nakayama, Mayumi Tsuji, Kenichi Umeda, Tatsunori Oguchi, Hiroki Konno, Moeko Noguchi-Shinohara, Yuji Kiuchi, Noriyuki Kodera, David B. Teplow, Kenjiro Ono
Summary: This study used high-speed atomic force microscopy to observe the structural dynamics of Afl42 PF at the single-molecule level and the effect of lecanemab, an anti-Afl PF antibody. It was found that PF had a curved nodal structure and underwent intramolecular cleavage. Lecanemab remained stable in binding to PFs and globular oligomers, inhibiting the formation of large aggregates. These results provide direct evidence for the mechanism by which antibody drugs interfere with the Afl aggregation process.
Article
Biophysics
Xiaoteng Liang, Yin Wang, Jie Song, Dan Xia, Qiang Li, Mingdong Dong
Summary: Silicene nanosheets (SNSs) activated by near-infrared (NIR) have been identified as an effective agent for disassembling A beta(33-42) aggregates. This study provides new insights into potential therapeutic strategies for Alzheimer's disease and related neurodegenerative diseases.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Physics, Applied
Jason Pan, Tommy Kmieciak, Yen-Ting Liu, Matthew Wildenradt, Yun-Sheng Chen, Yang Zhao
Summary: This review focuses on two main promising technologies for probing forces at the single molecule level in live cells. It reviews their theoretical fundamentals, recent technical advancements, and future directions.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Environmental Sciences
Yuxiang Liu, Songyuan Yang, Xianmei Liu, Pibin Guo, Keyong Zhang
Summary: This study investigates the driving factors behind temporal and spatial differences in CO2 emissions for China's transportation sector, using LMDI and M-R models to analyze changes over time and differences across 15 cities. Results show that income and transportation intensity are key factors influencing CO2 emissions, while multiple factors contribute to differences among cities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Environmental
Jinhyeong Jang, Calvin Andreas Hutomo, Chan Beum Park
Summary: This study reveals the effect of magnetic field-boosted bioelectrocatalysis on the dissociation of Aβ aggregates, the pathological hallmark of Alzheimer's disease. The Co-TiO2 electrode successfully triggers the dissociation process of Aβ aggregates with applied voltage, and the dissociation efficacy is enhanced when a static magnetic field is applied. In vitro and ex vivo evaluation results confirm the mitigating effect of the Co-TiO2 electrode on Aβ-associated neurotoxicity, as well as its ability to clear Aβ aggregates from AD mouse brain tissue.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Green & Sustainable Science & Technology
Dan Wu, Shuwei Li, Li Liu, Jiyao Lin, Shiqiu Zhang
Summary: The study evaluates the impact of changes in China's environmental protection on the shadow prices of sulfur dioxide and chemical oxygen demand, finding variations in shadow prices across provinces. Results show a significant upward trend in shadow prices from 2001 to 2015, with different regions being affected to varying degrees by technological, scale efficiency, and pure efficiency changes, emphasizing the importance of establishing a regionally differentiated policy framework.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Automation & Control Systems
Mouad Bensada Bullet, Abdellah Laazizi Bullet, Kaoutar Fri Bullet, Itto Ouzouhou
Summary: This research used computational fluid dynamics (CFD) and the finite element method (FEM) to study the gas tungsten arc welding (GTAW) process. The effects of welding operating parameters on weld integrity and material fracture were examined. The simulation showed that the capillary force presented by Marangoni convection mainly affects the weld pool geometry. Increasing the welding power and current intensity leads to the rapid growth of the melted zone, which may induce high residual stress and risk of metal fracture.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Automation & Control Systems
Mouad Bensada, Abdellah Laazizi, Kaoutar Fri, Itto Ouzouhou
Summary: This research study uses computational fluid dynamics (CFD) and finite element method (FEM) to analyze the gas tungsten arc welding (GTAW) process in order to achieve optimal weld quality and avoid material fracture caused by high welding temperatures. A 2D numerical model is developed to simulate the GTAW process on 304 L stainless steel, taking into account heat source distribution and convection movement in the melted pool. The simulation reveals that the capillary force generated by Marangoni convection primarily affects the geometry of the weld pool, and increasing welding power and current intensity can lead to rapid growth of the melted zone, increasing the risk of high residual stress and metal fracture.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Hongrun Ju, Yuanxia Liu, Shengrui Zhang
Summary: The increasing domestic grain trade is leading to the regional transmission of agricultural virtual water in China. Understanding the factors driving this flow is crucial for reducing the agricultural water footprint. The study reveals a decreasing trend in China's agricultural water footprint, with a higher proportion involved in interprovincial transfer. The spatial distribution of the water footprint is generally higher in the north of China. The intensity of the water footprint has improved over the years. Over 42% of China's agricultural water footprint is transferred between regions, but the flow pattern lacks rationality.
SUSTAINABLE PRODUCTION AND CONSUMPTION
(2023)
Article
Chemistry, Physical
Sergey Yu. Ketkov, Sheng-Yuan Tzeng, Elena A. Rychagova, Anton N. Lukoyanov, Wen-Bih Tzeng
Summary: Metallocenes, including methylcobaltocene, play important roles in various fields of chemistry. The ionization energy and vibrational structure of (Cp ')(Cp)Co can be influenced by introducing methyl substituents. The mass-analyzed threshold ionization spectrum and DFT calculations provide accurate information about the properties and transformations of (Cp ')(Cp)Co.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Review
Chemistry, Physical
Qifeng Mu, Jian Hu
Summary: Polymer mechanochemistry has experienced a renaissance due to the rapid development of mechanophores and principles governing mechanochemical transduction or material strengthening. It has not only provided fundamental guidelines for converting mechanical energy into chemical output, but also found applications in engineering and smart devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Da Hye Yang, Francesco Ricci, Fredrik L. Nordstrom, Na Li
Summary: Through systematic evaluation of the oiling-out behavior of procaine, we identified both stable and metastable liquid-liquid phase separation, and established phase diagrams to assist in rational selection of crystallization strategies.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Vikki Anand Varma, Simmie Jaglan, Mohd Yasir Khan, Sujin B. Babu
Summary: Designing engineering structures like nanocages, shells, and containers through self-assembly of colloids is a challenging problem. This work proposes a simple model for the subunit, which leads to the formation of monodispersed spherical cages or containers. The model with only one control parameter can be used to design cages with the desired radius.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Hainan Jiang, Yaolong He, Xiaolin Li, Zhiyao Jin, Huijie Yu, Dawei Li
Summary: The cycling lifespan and coulombic efficiency of lithium-ion batteries are crucial for high C-rate applications. The Li-ion concentration plays a crucial role in determining the mechanical integrity and structural stability of electrodes. This study focuses on graphite as the working electrode and establishes an experimental system to investigate the mechanical properties of composite graphite electrode at different C-rates. Considering the effect of Li-ion concentration in stress analysis is found to be significant.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Zhiye Wang, Yunchuan Li, Mingjun Sun
Summary: This study investigates the influence of intramolecular pi-pi interactions on the electronic transport capabilities of molecules. By designing and analyzing three pi-conjugated molecules, the researchers observe that different pi-conjugated structures have varying effects on electron transport. The findings provide a theoretical foundation for designing single-molecule electronic devices with multiple electron channels based on intramolecular pi-pi interactions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Yuandong Xu, Haoyang Feng, Chaoyang Dong, Yuqing Yang, Meng Zhou, Yajun Wei, Hui Guo, Yaqing Wei, Jishan Su, Yingying Ben, Xia Zhang
Summary: Hollow MoS2 cubes and spheres were successfully synthesized using a one-step hydrothermal method with the hard template method. The hollow MoS2 cubes exhibited higher specific capacitance and energy density compared to the hollow MoS2 spheres. The symmetrical supercapacitors assembled with these hollow structures showed good performance and high capacity retention after multiple cycles. These findings suggest that controlling the pore structure and surface characteristics of MoS2 is crucial for enhancing its electrochemical properties.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Ainhoa Oliden-Sanchez, Rebeca Sola-Llano, Joaquin Perez-Pariente, Luis Gomez-Hortiguela, Virginia Martinez-Martinez
Summary: The combination of photoactive molecules and inorganic structures is important for the development of advanced materials in optics. In this study, bulky dyes were successfully encapsulated in a zeolitic framework, resulting in emission throughout the visible spectrum.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Miaomiao Zhang, Cunyuan Pei, Qiqi Xiang, Lintao Liu, Zhongxu Dai, Huijuan Ma, Shibing Ni
Summary: The design of a solid electrolyte interphase (SEI) plays a crucial role in improving the electrochemical performance of anode materials. In this study, lithium difluoro(oxalate)borate (LiDFOB) is used as an electrolyte additive to form a protective SEI film on Li3VO4 (LVO) anodes. The addition of LiDFOB results in a dense, uniform, stable, and LiF-richer SEI, which enhances the Li-ion storage kinetics. The generated SEI also prevents further decomposition of the electrolyte and maintains the morphology of LVO anodes during charge/discharge processes. This work demonstrates the effectiveness of LiDFOB as a multi-functional additive for LiPF6 electrolytes and provides insights into SEI construction for high-performance LVO anodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
B. V. Andryushechkin, T. V. Pavlova, V. M. Shevlyuga
Summary: The atomic structure of the Ag(111)-p(4 x 4)-O phase was reexamined and two phases with the same periodicity were discovered. It was demonstrated that the accepted Ag6 model is incompatible with high-resolution oxygen-sensitive STM images.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
S. L. Romo-Avila, D. Marquez-Ruiz, R. A. Guirado-Lopez
Summary: In this study, we used density functional theory (DFT) calculations to investigate the interaction between model graphene oxide (GO) nanostructures and chlorine monoxide ClO. We aimed to understand the role of this highly oxidizing species in breaking C-C bonds and forming significant holes on GO sheets. Our results showed that C-C bonds in a single graphene oxide sheet can be broken through a simple mechanism involving the dissociation of two chemically attached ClO molecules. The formation of carbonyl groups and holes on the GO surface was also observed. This study provides important insights into the degradation of carbon nanotubes and the stability of GO during the myeloperoxidase (MPO) catalytic cycle.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Alberto Garcia-Fernandez, Birgit Kammlander, Stefania Riva, Hakan Rensmo, Ute B. Cappel
Summary: In this study, the X-ray stability of five different lead halide perovskite compositions (MAPbI3, MAPbCl3, MAPbBr3, FAPbBr3, CsPbBr3) was investigated using photoelectron spectroscopy. Different degradation mechanisms and resistance to X-ray were observed depending on the crystal composition. Overall, perovskite compositions based on the MA+ cation were found to be less stable than those based on FA+ or Cs+. Metallic lead formation was most easily observed in the chloride perovskite, followed by bromide, and very little in MAPbI3. Multiple degradation processes were identified for the bromide compositions, including ion migration, formation of volatile and solid products, as well as metallic lead. CsBr was formed as a solid degradation product on the surface of CsPbBr3.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Timofei Rostilov, Vadim Ziborov, Alexander Dolgoborodov, Mikhail Kuskov
Summary: The shock-loading behavior of nanomaterials is investigated in this study. It is found that shock compaction waves exhibit a distinct two-step structure, with the formation of faster precursor waves that travel ahead of the main compaction waves. The complexity of the shock Hugoniot curve of the tested nanomaterial is described, and the effect of initial porosity on the compressed states is demonstrated.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Sergey S. Nikitin, Alexander D. Koryakov, Elizaveta A. Antipinskaya, Alexey A. Markov, Mikhail V. Patrakeev
Summary: The stability of La1/3Sr2/3Fe1-xMnxO3-delta, a perovskite-type oxide, under reducing conditions is dependent on the manganese content. Increasing the manganese content leads to a decrease in stability. The behavior of iron and manganese in the oxide shows distinct differences, which can be attributed to the difference in the enthalpy of oxidation reactions. Additionally, the change in the La/Sr ratio affects the concentration of iron and manganese ions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Mosayeb Naseri, Shirin Amirian, Mehrdad Faraji, Mohammad Abdur Rashid, Maicon Pierre Lourenco, Venkataraman Thangadurai, D. R. Salahub
Summary: Inspired by the successful transfer of freestanding ultrathin films of SrTiO3 and BiFeO3, this study assessed the structural stability and investigated the electronic, optical, and thermoelectric properties of a group of two-dimensional perovskite-type materials called perovskenes. The findings revealed that these materials are wide bandgap semiconductors with potential application in UV shielding. Moreover, they exhibit better electrical and thermal conductivity at high temperatures, enabling efficient power generation in thermoelectric devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)