Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 13, Issue 11, Pages 5178-5186Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cp02149k
Keywords
-
Funding
- Natural Sciences and Engineering Research Council of Canada
Ask authors/readers for more resources
The gas-phase binding of small molecules to the Amyloid beta-40 peptide generated by electrospray ionization has been explored with collision-induced dissociation mass spectrometry and kinetic rate theory. This study discusses a simple procedure used to theoretically model the experimental breakdown diagrams for the A beta-40 peptide complexed with a series of aminosulfonate small molecules, namely homotaurine, 3-cyclohexylamino-2-hydroxy-1-propanesulfonic acid (CAPSO), 3-(1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl)propane-1-sulfonic acid, 3-(1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl) butane-1-sulfonic acid, and 3-(cyclohexylamino)propane-1-sulfonic acid. An alternative procedure employing an extrapolation procedure for k(E) is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available