Review
Biochemistry & Molecular Biology
Christopher M. Massa, Ziping Liu, Sheryse Taylor, Ashley P. Pettit, Marena N. Stakheyeva, Elena Korotkova, Valentina Popova, Elena N. Atochina-Vasserman, Andrew J. Gow
Summary: The modification of protein cysteine residues by nitric oxide is important for various biological functions. The formation of stable nitrosothiols under biologically relevant conditions is discussed in this review, with a focus on the factors influencing the selective nature of this modification. The review also explores the reaction mechanisms and the impact of sources of NO and the chemical nature of potential reaction targets.
Article
Chemistry, Multidisciplinary
Shevanuja Theivendran, Chengzhong Yu
Summary: This study presents the use of tetrasulfide-modified mesoporous organosilica nanoparticles for enhanced intracellular delivery of nitric oxide (NO), showing approximately 10 times higher delivery compared to a commercial NO donor. The tetrasulfide chemistry modulates the intracellular decomposition of SNO, shifting production from ammonia (NH3) to NO in glutathione-rich cancer cells, providing a new strategy to control NO levels in biological systems.
Article
Chemistry, Multidisciplinary
Wenjie Tao, Alina Yerbulekova, Curtis E. Moore, Hannah S. Shafaat, Shiyu Zhang
Summary: The interconversion between metal-S-nitrosothiol adduct and metal nitrosyl thiolate complex can regulate the direction of reversible S-(de)nitrosation. This process is sensitive to temperature, solvent coordination ability, and counterions, and copper centers can modulate the bond formation and cleavage through minor perturbations of the local environment.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Jon M. Fukuto, Cristina Perez-Ternero, Jessica Zarenkiewicz, Joseph Lin, Adrian J. Hobbs, John P. Toscano
Summary: The mechanisms of formation and degradation of S-Nitrosothiol (RS-NO) are not well understood. Hydropersulfides (RSSH) have been found to react with RS-NO, leading to its degradation and release of NO, potentially playing a key role in regulating steady-state RS-NO levels and serving as a storage form of NO.
Article
Medicine, Research & Experimental
Paulina M. Getsy, Alex P. Young, James N. Bates, Santhosh M. Baby, James M. Seckler, Alan Grossfield, Yee-Hsee Hsieh, Tristan H. J. Lewis, Michael W. Jenkins, Benjamin Gaston, Stephen J. Lewis
Summary: S-nitrosothiols have multiple effects on neural processes, improving breathing and alveolar gas exchange while promoting antinociception.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Sheryse Taylor, Alexa Murray, Mary Francis, Elena Abramova, Changjiang Guo, Debra L. Laskin, Andrew J. Gow
Summary: Acute exposure to ozone leads to oxidative stress and increased levels of nitric oxide and other reactive nitrogen species. SNO donors were found to reduce ozone-induced inflammation and modify macrophage phenotype. The hydrophobic SNO thiol pool plays a major role in regulating macrophage phenotype following ozone-induced injury.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Maria Oszajca, Angelika Jodlowska, Dorota Rutkowska-Zbik, Konrad Kieca, Grazyna Stoche
Summary: Conversion of NO to stable S-nitrosothiols is a significant biological strategy of NO storage and signal transduction, and metal ions and metalloproteins can promote the formation of S-nitrosothiols from NO. This study investigates the incorporation of NO to biologically relevant thiols using a model protein heme center. The formation of S-nitrosothiols is confirmed under anaerobic conditions, and the molecular mechanism involving N-coordinated S-nitrosothiols is elucidated. This work highlights the importance of reversible NO binding as a biological strategy for NO storage.
INORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Richard T. Premont, David J. Singel, Jonathan S. Stamler
Summary: This chapter reviews the crucial role of hemoglobin in carrying and releasing SNO in the autoregulation of blood flow, and its physiological and pathological implications for oxygen delivery. Additionally, therapeutic opportunities to optimize oxygen delivery at the level of tissue blood flow are highlighted.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Navendu S. Patil, Jonathan B. Dingwell, Joseph P. Cusumano
Summary: This study identifies the important role of task-level motor regulation in fall avoidance and proposes an adaptive hierarchical control/regulation strategy. Humans have already learned to perform goal-directed tasks during nominal walking conditions, suggesting low implementation costs for such controllers biologically.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Noah Neidigh, Alyssa Alexander, Parker van Emmerik, Allison Higgs, Logan Plack, Charles Clem, Daniel Cater, Nadzeya Marozkina, Benjamin Gaston
Summary: A noninvasive device using ultraviolet light was developed to measure S-nitrosothiols in mammalian tissues. The method was sensitive, specific, and reproducible in rats and humans. This approach may have implications for studying human diseases.
Article
Agriculture, Multidisciplinary
Bo Wang, Xinglei Gao, Haixin Yang, Huimin Liu, Guizhi Fan
Summary: This study systematically characterized and identified the bZIP family genes in Betula platyphylla, and found that BpbZIP26 gene regulates triterpenoid production. This work provides candidate genes for S-nitrosothiol response and triterpenoid production in Betula platyphylla.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Christopher H. Switzer, Jon M. Fukuto
Summary: It has been found that hydrogen sulfide, hydropersulfides, and other polysulfide species are biochemically interconnected. The unique chemistry of hydropersulfides suggests that they may possess protective properties to help cells withstand oxidative and electrophilic stress. However, hydropersulfides and polysulfides can also generate oxidative and electrophilic stress as well. This article discusses the chemistry, biochemistry, and physiological implications of hydropersulfides and polysulfides, particularly their potential protective properties against various stresses and their role as stressors or signaling agents.
Article
Biochemistry & Molecular Biology
Richard T. Premont, James D. Reynolds, Rongli Zhang, Jonathan S. Stamler
Summary: Red blood cell-mediated vasodilation is crucial for oxygen delivery, facilitated by the conversion of heme-bound nitric oxide into vasodilator S-nitrosothiol. This process is regulated by a strictly conserved Cys residue in hemoglobin. The model of a three-gas respiratory cycle (O-2/NO/CO2) is supported by the coupling of hemoglobin allostery to NO conversion and SNO release.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Wuwei Li, Danyang Wang, Ka Un Lao, Xuewei Wang
Summary: This study demonstrates the significant impact of buffer concentration on the stability of RSNOs. The optimal buffer concentration for RSNOs is close to their own concentration. Lower buffer concentrations cannot resist the pH drop caused by RSNO decomposition, while higher buffer concentrations consume NO/N2O3 and reduce RSNO stability.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Chemistry, Applied
Aline Bonifacie, Aurelie Promeyrat, Gilles Nassy, Philippe Gatellier, Veronique Sante-Lhoutellier, Laetitia Theron
Summary: Nitrite, when added to cured and cooked meat, enhances heme iron nitrosylation and S-nitrosation but not N-nitrosation. The presence of ascorbate helps reduce nitrosamine levels and protect nitrosothiols from degradation. The study provides new insights into the chemical reactivity of NOCs in a cured meat model.
Article
Chemistry, Physical
Maxim V. Ivanov, Marat R. Talipov, Qadir K. Timerghazin
JOURNAL OF CHEMICAL PHYSICS
(2015)
Article
Chemistry, Physical
Dmitry G. Khomyakov, Qadir K. Timerghazin
JOURNAL OF CHEMICAL PHYSICS
(2017)
Article
Chemistry, Multidisciplinary
Marat R. Talipov, Dmitry G. Khomyakov, Ming Xian, Qadir K. Timerghazin
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2013)
Article
Chemistry, Physical
Marat R. Talipov, Qadir K. Timerghazin, Rustam L. Safiullin, Sergey L. Khursan
JOURNAL OF PHYSICAL CHEMISTRY A
(2013)
Article
Chemistry, Physical
Chun C. Mak, Qadir K. Timerghazin, Gilles H. Peslherbe
JOURNAL OF PHYSICAL CHEMISTRY A
(2013)
Article
Chemistry, Physical
Marat R. Talipov, Qadir K. Timerghazin
JOURNAL OF PHYSICAL CHEMISTRY B
(2013)
Article
Chemistry, Physical
Marat R. Talipov, Anitha Boddeda, Qadir K. Timerghazin, Rajendra Rathore
JOURNAL OF PHYSICAL CHEMISTRY C
(2014)
Article
Chemistry, Physical
Qadir K. Timerghazin, Marat R. Talipov
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2013)
Article
Biochemistry & Molecular Biology
Majher I. Sarker, Tasnuva Shahrin, Mark G. Steinmetz, Qadir K. Timerghazin
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2013)
Article
Chemistry, Physical
Lena V. Ivanova, Becka J. Anton, Qadir K. Timerghazin
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2014)
Article
Chemistry, Organic
Saber Mirzaei, Denan Wang, Sergey Lindeman, Qadir K. Timerghazin, Rajendra Rathore
Article
Chemistry, Multidisciplinary
Valiallah Hosseininasab, Alison C. McQuilken, Abolghasem (Gus) Bakhoda, Jeffery A. Bertke, Qadir K. Timerghazin, Timothy H. Warren
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Saber Mirzaei, Sergey Lindeman, Denan Wang, M. Saeed Mirzaei, Qadir K. Timerghazin
Summary: The discovery of a novel metastable polymorph of a calix[4]arene molecule undergoing distinct transformations, including a reversible thermal-induced rotation and irreversible dissolvation/recrystallization, demonstrates the unique structural changes and packing arrangements that can be achieved.
Article
Chemistry, Physical
Niloufar Hendinejad, Qadir K. Timerghazin
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Lena V. Ivanova, Daniel Cibich, Gregory Deye, Marat R. Talipov, Qadir K. Timerghazin
Article
Chemistry, Physical
Sergey Yu. Ketkov, Sheng-Yuan Tzeng, Elena A. Rychagova, Anton N. Lukoyanov, Wen-Bih Tzeng
Summary: Metallocenes, including methylcobaltocene, play important roles in various fields of chemistry. The ionization energy and vibrational structure of (Cp ')(Cp)Co can be influenced by introducing methyl substituents. The mass-analyzed threshold ionization spectrum and DFT calculations provide accurate information about the properties and transformations of (Cp ')(Cp)Co.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Review
Chemistry, Physical
Qifeng Mu, Jian Hu
Summary: Polymer mechanochemistry has experienced a renaissance due to the rapid development of mechanophores and principles governing mechanochemical transduction or material strengthening. It has not only provided fundamental guidelines for converting mechanical energy into chemical output, but also found applications in engineering and smart devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Da Hye Yang, Francesco Ricci, Fredrik L. Nordstrom, Na Li
Summary: Through systematic evaluation of the oiling-out behavior of procaine, we identified both stable and metastable liquid-liquid phase separation, and established phase diagrams to assist in rational selection of crystallization strategies.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Vikki Anand Varma, Simmie Jaglan, Mohd Yasir Khan, Sujin B. Babu
Summary: Designing engineering structures like nanocages, shells, and containers through self-assembly of colloids is a challenging problem. This work proposes a simple model for the subunit, which leads to the formation of monodispersed spherical cages or containers. The model with only one control parameter can be used to design cages with the desired radius.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Hainan Jiang, Yaolong He, Xiaolin Li, Zhiyao Jin, Huijie Yu, Dawei Li
Summary: The cycling lifespan and coulombic efficiency of lithium-ion batteries are crucial for high C-rate applications. The Li-ion concentration plays a crucial role in determining the mechanical integrity and structural stability of electrodes. This study focuses on graphite as the working electrode and establishes an experimental system to investigate the mechanical properties of composite graphite electrode at different C-rates. Considering the effect of Li-ion concentration in stress analysis is found to be significant.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Zhiye Wang, Yunchuan Li, Mingjun Sun
Summary: This study investigates the influence of intramolecular pi-pi interactions on the electronic transport capabilities of molecules. By designing and analyzing three pi-conjugated molecules, the researchers observe that different pi-conjugated structures have varying effects on electron transport. The findings provide a theoretical foundation for designing single-molecule electronic devices with multiple electron channels based on intramolecular pi-pi interactions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Yuandong Xu, Haoyang Feng, Chaoyang Dong, Yuqing Yang, Meng Zhou, Yajun Wei, Hui Guo, Yaqing Wei, Jishan Su, Yingying Ben, Xia Zhang
Summary: Hollow MoS2 cubes and spheres were successfully synthesized using a one-step hydrothermal method with the hard template method. The hollow MoS2 cubes exhibited higher specific capacitance and energy density compared to the hollow MoS2 spheres. The symmetrical supercapacitors assembled with these hollow structures showed good performance and high capacity retention after multiple cycles. These findings suggest that controlling the pore structure and surface characteristics of MoS2 is crucial for enhancing its electrochemical properties.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Ainhoa Oliden-Sanchez, Rebeca Sola-Llano, Joaquin Perez-Pariente, Luis Gomez-Hortiguela, Virginia Martinez-Martinez
Summary: The combination of photoactive molecules and inorganic structures is important for the development of advanced materials in optics. In this study, bulky dyes were successfully encapsulated in a zeolitic framework, resulting in emission throughout the visible spectrum.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Miaomiao Zhang, Cunyuan Pei, Qiqi Xiang, Lintao Liu, Zhongxu Dai, Huijuan Ma, Shibing Ni
Summary: The design of a solid electrolyte interphase (SEI) plays a crucial role in improving the electrochemical performance of anode materials. In this study, lithium difluoro(oxalate)borate (LiDFOB) is used as an electrolyte additive to form a protective SEI film on Li3VO4 (LVO) anodes. The addition of LiDFOB results in a dense, uniform, stable, and LiF-richer SEI, which enhances the Li-ion storage kinetics. The generated SEI also prevents further decomposition of the electrolyte and maintains the morphology of LVO anodes during charge/discharge processes. This work demonstrates the effectiveness of LiDFOB as a multi-functional additive for LiPF6 electrolytes and provides insights into SEI construction for high-performance LVO anodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
B. V. Andryushechkin, T. V. Pavlova, V. M. Shevlyuga
Summary: The atomic structure of the Ag(111)-p(4 x 4)-O phase was reexamined and two phases with the same periodicity were discovered. It was demonstrated that the accepted Ag6 model is incompatible with high-resolution oxygen-sensitive STM images.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
S. L. Romo-Avila, D. Marquez-Ruiz, R. A. Guirado-Lopez
Summary: In this study, we used density functional theory (DFT) calculations to investigate the interaction between model graphene oxide (GO) nanostructures and chlorine monoxide ClO. We aimed to understand the role of this highly oxidizing species in breaking C-C bonds and forming significant holes on GO sheets. Our results showed that C-C bonds in a single graphene oxide sheet can be broken through a simple mechanism involving the dissociation of two chemically attached ClO molecules. The formation of carbonyl groups and holes on the GO surface was also observed. This study provides important insights into the degradation of carbon nanotubes and the stability of GO during the myeloperoxidase (MPO) catalytic cycle.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Alberto Garcia-Fernandez, Birgit Kammlander, Stefania Riva, Hakan Rensmo, Ute B. Cappel
Summary: In this study, the X-ray stability of five different lead halide perovskite compositions (MAPbI3, MAPbCl3, MAPbBr3, FAPbBr3, CsPbBr3) was investigated using photoelectron spectroscopy. Different degradation mechanisms and resistance to X-ray were observed depending on the crystal composition. Overall, perovskite compositions based on the MA+ cation were found to be less stable than those based on FA+ or Cs+. Metallic lead formation was most easily observed in the chloride perovskite, followed by bromide, and very little in MAPbI3. Multiple degradation processes were identified for the bromide compositions, including ion migration, formation of volatile and solid products, as well as metallic lead. CsBr was formed as a solid degradation product on the surface of CsPbBr3.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Timofei Rostilov, Vadim Ziborov, Alexander Dolgoborodov, Mikhail Kuskov
Summary: The shock-loading behavior of nanomaterials is investigated in this study. It is found that shock compaction waves exhibit a distinct two-step structure, with the formation of faster precursor waves that travel ahead of the main compaction waves. The complexity of the shock Hugoniot curve of the tested nanomaterial is described, and the effect of initial porosity on the compressed states is demonstrated.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Sergey S. Nikitin, Alexander D. Koryakov, Elizaveta A. Antipinskaya, Alexey A. Markov, Mikhail V. Patrakeev
Summary: The stability of La1/3Sr2/3Fe1-xMnxO3-delta, a perovskite-type oxide, under reducing conditions is dependent on the manganese content. Increasing the manganese content leads to a decrease in stability. The behavior of iron and manganese in the oxide shows distinct differences, which can be attributed to the difference in the enthalpy of oxidation reactions. Additionally, the change in the La/Sr ratio affects the concentration of iron and manganese ions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Mosayeb Naseri, Shirin Amirian, Mehrdad Faraji, Mohammad Abdur Rashid, Maicon Pierre Lourenco, Venkataraman Thangadurai, D. R. Salahub
Summary: Inspired by the successful transfer of freestanding ultrathin films of SrTiO3 and BiFeO3, this study assessed the structural stability and investigated the electronic, optical, and thermoelectric properties of a group of two-dimensional perovskite-type materials called perovskenes. The findings revealed that these materials are wide bandgap semiconductors with potential application in UV shielding. Moreover, they exhibit better electrical and thermal conductivity at high temperatures, enabling efficient power generation in thermoelectric devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)