Article
Obstetrics & Gynecology
Anna S. Andersen, Sidsel Linneberg Rathcke, Trine Tang Christensen, Anne Sorensen
Summary: Fetal biometrics above the 90th centile at the second trimester scan increase the risk of gestational diabetes mellitus (GDM).
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Fazil Avci, Salih Serin, Murat Bakacak, Onder Ercan, Bulent Kostu, Deniz Cemgil Arikan, Mehmet Kulhan, Ahmet Bilgi, Cetin Celik, Ayse Ceren Duymus, Nur Gozde Kulhan
Summary: We investigated the correlation between fetal clavicle length and gestational age in pregnant patients from 14 and 27 weeks of gestation. The results showed a significant positive correlation between fetal clavicle length and gestational week. We suggest that the "1 mm = 1 week" rule can be used for patients with anomalies of the cerebellum and vermis, as well as for patients with unknown last menstrual period.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Acoustics
U. Nowacka, I Papastefanou, A. Bouariu, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study investigates the additional value of second-trimester placental growth factor (PlGF) in predicting small-for-gestational-age (SGA) neonates and examines second-trimester contingent screening strategies. The results show that the combination of maternal risk factors, estimated fetal weight (EFW), uterine artery pulsatility index (UtA-PI), and PlGF significantly improves the prediction of SGA compared to maternal risk factors alone. However, the incremental improvement decreases when PlGF is added to screening with a combination of maternal risk factors, EFW, and UtA-PI. By reserving measurements of UtA-PI and PlGF for a certain percentage of the population, similar detection rates and false-positive rates can be achieved. The study concludes that the combination of maternal risk factors, EFW, UtA-PI, and PlGF provides an effective prediction of SGA in the second trimester.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Laura C. Ha, Amanda Craig, Matthew R. Grace, Sarah S. Osmundson, Emily W. Taylor, Lisa C. Zuckerwise
Summary: This study assessed the accuracy of standard estimated fetal weight assessment in fetuses with gastroschisis or omphalocele by comparing prenatal assessment of fetal weight with actual birthweight. The results showed that the standard measurement of fetal weight in these fetuses is at least comparable with previously established margins of error for ultrasound assessment of fetal weight. Standard estimated fetal weight assessment remains an appropriate method for estimating fetal weight in fetuses with abdominal wall defects.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Obstetrics & Gynecology
Berta Serrano, Erika Bonacina, Carlota Rodo, Pablo Garcia-Manau, Maria Angeles Sanchez-Duran, Maria Pancorbo, Cristina Forcada, Maria Teresa Murcia, Ana Perestelo, Mireia Armengol-Alsina, Manel Mendoza, Elena Carreras
Summary: This study compared the predictive accuracy of the Gaussian algorithm and the FMF algorithm for early-onset pre-eclampsia (PE) and small for gestational age (SGA). The results showed that these two algorithms had similar performances for most outcomes and marker combinations. However, the Gaussian algorithm had significant differences in predicting early-onset PE in certain combinations.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Alice Self, Lama Daher, Michael Schlussel, Nia Roberts, Christos Ioannou, Aris T. Papageorghiou
Summary: Many vulnerable women seek antenatal care late in pregnancy. This study examines various methods of estimating gestational age and finds that ultrasound measurement is more accurate than fundal height, with cerebellar measurement being the most accurate.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Chelsea A. DeBolt, Minhazur Sarker, Natalie Cohen, Elianna Kaplowitz, Ayisha Buckley, Joanne Stone, Angela Bianco
Summary: This study aims to determine whether abnormal individual biometric parameters in early-onset fetal growth restriction are associated with adverse neonatal outcomes. The study found that patients with fetal growth restriction and abnormal biometric parameters were more likely to be nulliparous, diagnosed with severe growth restriction, and received antenatal corticosteroids.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Medicine, General & Internal
Olga Buerger, Tania Elger, Antonia Varthaliti, Argyro Syngelaki, Alan Wright, Kypros H. Nicolaides
Summary: In this study, we found that maternal characteristics and medical history can be used to predict the risk of Gestational Diabetes Mellitus (GDM), with a higher risk in twin pregnancies. Factors such as maternal age, weight, family history, racial background, and conception method all influence the risk of GDM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yogitha Poojari, Prudhvinath Reddy Annapureddy, Sharmila Vijayan, Vinoth Kumar Kalidoss, Mf Yuvaraj, Pk Sankaran
Summary: Advanced maternal age affects fetal growth pattern, with lower third trimester fetal parameters compared to younger mothers. Head circumference is an important indicator for estimating the estimated date of delivery in advanced maternal age group.
Article
Obstetrics & Gynecology
Eiri Shima, Mina Itsukaichi, Kosuke Yoshihara, Tatsuya Ishiguro, Kazufumi Haino, Koji Nishino, Nobumichi Nishikawa, Koji Nishijima, Takayuki Enomoto
Summary: This study aimed to evaluate the influence of abdominal radical trachelectomy performed during pregnancy on the fetus. The results showed that performing abdominal radical trachelectomy for the treatment of early-stage cervical cancer during pregnancy does not have a significant impact on fetal growth.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Computer Science, Interdisciplinary Applications
Tommaso Ciceri, Letizia Squarcina, Alessandro Pigoni, Adele Ferro, Florian Montano, Alessandra Bertoldo, Nicola Persico, Simona Boito, Fabio Maria Triulzi, Giorgio Conte, Paolo Brambilla, Denis Peruzzo
Summary: Fetal Magnetic Resonance Imaging (MRI) is a crucial noninvasive diagnostic tool for assessing the development of the central nervous system in fetuses. Recent advancements in toolkits allow for the reconstruction of high-resolution 3D volumes of the fetal brain using acquired 2D images, enabling three-dimensional analysis.
Article
Obstetrics & Gynecology
A. Zhang, T. T. Stolk, E. Lopriore, L. Sun, T. Duan, D. Oepkes
Summary: This study found that second-trimester abdominal circumference discordant monochorionic twins are at increased risk of adverse perinatal outcomes, including abnormal umbilical artery and ductus venosus flow, low birth weight, birth weight discordance, intrauterine fetal demise, and severe neonatal morbidity. Early and intensified fetal surveillance for these twins is necessary to improve perinatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
L. Yovera, M. Zaharia, T. Jachymski, O. Velicu-Scraba, C. Coronel, C. de Paco Matallana, G. Georgiopoulos, K. H. Nicolaides, M. Charakida
Summary: The study showed that fetuses of mothers with gestational diabetes mellitus (GDM) have significantly reduced right ventricular function, while left ventricular global longitudinal function remains similar in GDM pregnancies compared to controls, except for reduced contractility in the left ventricular basal segment. The global sphericity index is only reduced in GDM pregnancies at 32+1 to 40+1 weeks.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Szymon S. Plotka, Michal K. Grzeszczyk, Paula I. Szenejko, Kinga Zebrowska, Natalia A. Szymecka-Samaha, Tomas Legowik, Michal A. Lipa, Katarzyna Kosinska-Kaczy, Robert Brawura-Biskupski-Samaha, Ivana Isgum, Clara I. Sanchez, Arkadiusz Sitek
Summary: This study developed a deep learning method to estimate fetal weight using ultrasound video scans of the fetal abdomen, and achieved similar performance to human readers. The method shows promising potential in directly estimating fetal weight.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Clinical Neurology
Maria Camila Cortes-Albornoz, Camilo Calixto, M. Alejandra Bedoya, Ryne A. Didier, Judy A. Estroff, Camilo Jaimes
Summary: This study characterized the normal fetal brain growth between the 12th and 20th weeks of gestational age. The results showed distinct trajectories for different compartments of the brain, with the fastest growth observed in the supratentorial brain and extra-axial cerebrospinal fluid.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Obstetrics & Gynecology
Anna Kajdy, Dorota Sys, Artur Pokropek, Steven W. Shaw, Tung-Yao Chang, Pavel Calda, Ganesh Acharya, Maya Ben-Zion, Tal Biron-Shental, Dariusz Borowski, Bartosz Czuba, Adolfo Etchegaray, Stepan Feduniw, Rosario Garcia-Mandujano, Monica Garcia Santacruz, Maria M. Gil, Sonia Hassan, Sebastian Kwiatkowski, Arancha Martin-Arias, Raigam Jafet Martinez-Portilla, Federico Prefumo, Michal Rabijewski, Laurent J. Salomon, Heidi Tiller, Stefan Verlohren, Hian Yan Voon, Omar Fernando Yanque-Robles, Soon Leong Yong, Liona C. Poon
Summary: This study examines risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. The results indicate that pregnant women in high-income economies experience higher levels of anxiety and depression. Factors such as the need for psychiatric treatment before pregnancy, restrictions in social distancing and access to leisure activities, pregnancy-related complications, fear of adverse outcomes in children related to COVID-19, and financial burden are associated with increased risk of anxiety and depression during pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Maria Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S. Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria del Mar Gil, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L. Godwin, Sami Gottlieb, Eduard Gratacos, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen L. Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Torri D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A. Tippett Barr, Jorge E. Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M. Tielsch
Summary: This sequential, prospective meta-analysis aimed to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to disease severity, maternal morbidities, neonatal mortality and morbidity, and adverse birth outcomes. Data from 21 participating studies were included, and risk factors and outcomes were analyzed. The study found that women with comorbidities, HIV infection, prepregnancy underweight, and anemia were at increased risk for severe COVID-19-related outcomes and adverse birth outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Guixue Hou, Ya Gao, Liona C. Poon, Yan Ren, Chunwei Zeng, Bo Wen, Argyro Syngelaki, Liang Lin, Jin Zi, Fengxia Su, Weiwei Xie, Fang Chen, Kypros H. Nicolaides
Summary: This study defined the lipidomic profile in plasma during pregnancy and identified lipid biomarkers for the prediction of gestational diabetes mellitus (GDM) in early pregnancy.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Yi Man Isabella Wah, Ye Cao, Chun Yiu Law, Kwong Wai Choy, Tak Yeung Leung, Hoi Wan Angel Kwan, Liona C. Poon Poon
Summary: This article reports a case of recurrent congenital microcephaly in a Chinese family. Two affected fetuses presented with microcephaly early in the second trimester with agenesis of the corpus callosum. Whole-exome sequencing analysis detected two compound heterozygous candidate variants in the SASS6 gene, but the pathomechanism is still unknown.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Sumaiya Adam, Harold David McIntyre, Kit Ying Tsoi, Anil Kapur, Ronald C. Ma, Stephanie Dias, Pius Okong, Moshe Hod, Liona C. Poon, Graeme N. Smith, Lina Bergman, Esraa Algurjia, Patrick O'Brien, Virna P. Medina, Cynthia Maxwell, Lesley Regan, Mary L. Rosser, Bo Jacobsson, Mark A. Hanson, Sharleen L. O'Reilly, Fionnuala M. McAuliffe
Summary: Gestational diabetes (GDM) affects approximately 17 million pregnancies worldwide. Women with a history of GDM are at a significantly higher risk of developing type 2 diabetes and cardiovascular disease compared to those without prior GDM. Although prevention and delayed progression of GDM to type 2 diabetes is possible, it is not widely practiced. Considering the increasing rates of type 2 diabetes and CVD in women globally, it is crucial to utilize pregnancy as an opportunity for early identification and preventive intervention.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Cynthia Maxwell, Rachelle Shirley, Amy C. O'Higgins, Mary L. Rosser, Patrick O'Brien, Moshe Hod, Sharleen L. O'Reilly, Virna P. Medina, Graeme N. Smith, Mark A. Hanson, Sumaiya Adam, Ronald C. Ma, Anil Kapur, Harold David McIntyre, Bo Jacobsson, Liona C. Poon, Lina Bergman, Lesley Regan, Esraa Algurjia, Fionnuala M. McAuliffe
Summary: Obesity is a chronic, progressive, relapsing, and treatable neurobehavioral disease that affects women's health and requires a focus on optimizing health outcomes rather than weight loss. Appropriate and sensitive language, as well as trauma-informed care, is necessary when discussing obesity.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Liona C. Poon, Long Nguyen-Hoang, Graeme N. Smith, Lina Bergman, Patrick O'Brien, Moshe Hod, Pius Okong, Anil Kapur, Cynthia Maxwell, Harold David McIntyre, Bo Jacobsson, Esraa Algurjia, Mark A. Hanson, Mary L. Rosser, Ronald C. Ma, Sharleen L. O'Reilly, Lesley Regan, Sumaiya Adam, Virna P. Medina, Fionnuala M. McAuliffe
Summary: Hypertensive disorders of pregnancy (HDP) are the leading cause of maternal and perinatal morbidity and mortality, accounting for 16% of maternal deaths in high-income countries and approximately 25% in low- and middle-income countries. HDP increases the risk of future cardiovascular disease. Failure to achieve normal cardiovascular adaptation during pregnancy is associated with the development of HDP. Women with a history of HDP may experience long-term hemodynamic alterations, predisposing them to cardiovascular morbidity and mortality. Therefore, it is crucial to identify underlying cardiovascular risk factors during pregnancy and the postpartum period and develop strategies for lifestyle and therapeutic interventions to reduce the risk of future cardiovascular disease in women with a history of HDP.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Sarah Louise Killeen, Niamh Donnellan, Sharleen L. O'Reilly, Mark A. Hanson, Mary L. Rosser, Virna P. Medina, Chandni Maria Jacob, Hema Divakar, Moshe Hod, Liona C. Poon, Lina Bergman, Patrick O'Brien, Anil Kapur, Bo Jacobsson, Cynthia Maxwell, Harold David McIntyre, Lesley Regan, Esraa Algurjia, Ronald C. Ma, Sumaiya Adam, Fionnuala M. McAuliffe
Summary: The period before and during pregnancy is crucial for addressing malnutrition and reducing noncommunicable disease risks. The FIGO Nutrition Checklist is a tool designed to address these issues by assessing dietary requirements, body mass index, diet quality, and micronutrients. It generates awareness, identifies risks, and collects information for health-promoting conversations between women and healthcare professionals.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Acoustics
Nana Matsuzawa, Liona C. Poon, Megumi Machida, Takako Nakamura, Kohtaro Uenishi, Yi Man Wah, Sakita Moungmaithong, Atsuo Itakura, Hideaki Chiyo, Ritsuko K. Pooh
Summary: Diagonal echogenic lines outside the lateral ventricle, known as cat-ear-line (CEL), are often observed in the normal fetal brain. However, abnormal CEL shapes have been observed in cases of malformation of cortical development (MCD). This study aimed to compare the development of CEL in normal cases versus MCD cases, and found that the visualization rate of CEL in MCD cases was significantly lower than that in the normal control group.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Acoustics
D. L. Rolnik, A. Syngelaki, N. O'Gorman, D. Wright, L. C. Poon, K. H. Nicolaides
Summary: This study aimed to investigate the effects of aspirin on mean arterial pressure (MAP) and mean uterine artery pulsatility index (UtA-PI) in women at increased risk of preterm pre-eclampsia. The results showed that aspirin did not significantly affect MAP, but it was associated with a significant decrease in mean UtA-PI, particularly before 20 weeks of gestation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Sakita K. Moungmaithong, Angel H. S. Kwan, Ada W. Tse, Natalie K. C. Wong, Michelle S. S. Lam, Jing Wang, Liona C. Poon, Daljit S. Sahota
Summary: International professional organizations recommend aspirin prophylaxis to women at high risk for preterm preeclampsia (PE) in the first trimester. However, the UK Fetal Medicine Foundation (FMF) screening test using mean arterial pressure (MAP), uterine artery pulsatility index (UTPI), and placental growth factor (PlGF) has shown lower detection rates (DRs) in Asian population studies. Additional biomarkers are needed in Asian women to improve screening for preterm and term PE.
Article
Acoustics
S. Moungmaithong, X. Wang, C. S. L. Lau, A. W. T. Tse, N. M. W. Lee, H. H. Y. Leung, L. C. Poon, D. S. Sahota
Summary: Adding GlyFn to the FMF triple test increases the screening sensitivity for both preterm and any-onset pre-eclampsia in an Asian population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Yan Yu Li, Wing Yi Lok, Liona C. Poon, Choi Wah Kong, William W. K. To
Summary: The objective of this study was to evaluate the acceptance of COVID-19 vaccination among pregnant women and to compare their anxiety and knowledge on COVID-19 with a previous study. A cross-sectional survey was conducted in antenatal clinics in Hong Kong, China. The results showed that pregnant women in the current survey were less worried about COVID-19 compared to the previous survey.
MATERNAL-FETAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Catherine Cluver, Christianne de Groot, Ben W. Mol, Kellie E. Murphy, Jane E. Norman, Rodolfo Pacagnella, Kirsten Palmer, Liona C. Poon, Daniel L. Rolnik, Catherine Y. Spong, Sarah J. Stock, Shakila Thangaratinam, Stephen Tong, Corine Verhoeven, Lan N. Vuong, Sue P. Walker, Liu Xiaohua
Review
Obstetrics & Gynecology
Piya Chaemsaithong, Maria M. Gil, Noppadol Chaiyasit, Diana Cuenca-Gomez, Walter Plasencia, Valeria Rolle, Liona C. Poon
Summary: This study aimed to assess the diagnostic accuracy of placental growth factor and placental growth factor-based models in predicting the development of preeclampsia in asymptomatic women. The findings suggest that placental growth factor combined with maternal factors has the highest predictive performance for early preeclampsia, while placental growth factor-based models perform similarly to soluble fms-like tyrosine kinase-1-placental growth factor ratio for any-onset preeclampsia in the third trimester. Standardized research using consistent models is needed to accurately predict preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)