Conceptualizing a tool to optimize therapy based on dynamic heterogeneity

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation

(2011) Daniel A. Charlebois et al.   PHYSICAL REVIEW LETTERS

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of Dosing for EGFR-Mutant Non-Small Cell Lung Cancer with Evolutionary Cancer Modeling

(2011) J. Chmielecki et al.   Science Translational Medicine

Frequent Optical Imaging during Breast Cancer Neoadjuvant Chemotherapy Reveals Dynamic Tumor Physiology in an Individual Patient

(2010) Albert E. Cerussi et al.   ACADEMIC RADIOLOGY

Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)

(2010) T. P. Hughes et al.   BLOOD

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

CA 15-3: Uses and limitation as a biomarker for breast cancer

(2010) Michael J. Duffy et al.   CLINICA CHIMICA ACTA

Nontoxic, Fiscally Responsible, Future of Oncology

(2010) Giannoula Lakka Klement et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers

(2010) Ke Zen et al.   MEDICINAL RESEARCH REVIEWS

Tracing the tumor lineage

(2010) Nicholas E. Navin et al.   Molecular Oncology

Non-genetic cell-to-cell variability and the consequences for pharmacology

(2009) Mario Niepel et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Non-genetic heterogeneity of cells in development: more than just noise

(2009) S. Huang   DEVELOPMENT

The Emerging Low-dose Therapy for Advanced Cancers

(2009) Jahangir Satti   Dose-Response

Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000

(2009) A Möricke et al.   LEUKEMIA

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells

(2009) Tibor Kalmar et al.   PLOS BIOLOGY

Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies

(2009) Jasmine Foo et al.   PLoS Computational Biology

The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data

(2009) Regina Samaga et al.   PLoS Computational Biology

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Capturing Pluripotency

(2008) Jose Silva et al.   CELL

Randomized Phase III Trial of Weekly Compared With Every-3-Weeks Paclitaxel for Metastatic Breast Cancer, With Trastuzumab for all HER-2 Overexpressors and Random Assignment to Trastuzumab or Not in HER-2 Nonoverexpressors: Final Results of Cancer and Leukemia Group B Protocol 9840

(2008) Andrew D. Seidman et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE

Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: Report of the HD CWS-96 trial

(2008) Thomas Klingebiel et al.   PEDIATRIC BLOOD & CANCER