Journal
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
Volume 211, Issue 6, Pages 1364-1371Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pssa.201330276
Keywords
cyclic voltammetry; microelectrode arrays; neurotransmitters
Funding
- Helmholtz Young Investigator program
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Fast scan cyclic voltammetry is a powerful technique for selective detection of biogenic amines in vivo and in vitro. Here we investigate this technique for multichannel spatiotemporal detection of neurotransmitter concentrations on a chip, using metal microelectrode arrays. The array-based approach allows monitoring concentration gradients of redox-active species at multiple highly localized (3 mu m) positions simultaneously, while maintaining selectivity from the characteristic voltammogram shapes. We demonstrate that concentration fluctuations at individual electrode locations are resolved after spatially confined neurotransmitter injections. Furthermore, we discuss effects of microelectrode degradation caused by electrode sweeping during long-term experiments.
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