Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases
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Title
Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases
Authors
Keywords
Methyleugenol, Oxidative metabolites, DNA damage, DNA double-strand breaks, Topoisomerase inhibition, Micronucleus induction
Journal
ARCHIVES OF TOXICOLOGY
Volume 90, Issue 11, Pages 2809-2823
Publisher
Springer Nature
Online
2015-11-05
DOI
10.1007/s00204-015-1625-3
References
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- Methyleugenol Genotoxicity in the Fischer 344 Rat Using the Comet Assay and Pathway-Focused Gene Expression Profiling
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- H2AX phosphorylation as a genotoxicity endpoint
- (2009) Gary Peter Watters et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- The Efficacy of Topoisomerase II-Targeted Anticancer Agents Reflects the Persistence of Drug-Induced Cleavage Complexes in Cells†
- (2008) Omari J. Bandele et al. BIOCHEMISTRY
- (–)-Epigallocatechin Gallate, A Major Constituent of Green Tea, Poisons Human Type II Topoisomerases
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- Dietary Polyphenols as Topoisomerase II Poisons: B Ring and C Ring Substituents Determine the Mechanism of Enzyme-Mediated DNA Cleavage Enhancement
- (2008) Omari J. Bandele et al. CHEMICAL RESEARCH IN TOXICOLOGY
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