Article
Medicine, General & Internal
Tanja Veljovic, Milanko Djuric, Jelena Mirnic, Ivana Gusic, Aleksandra Maletin, Bojana Ramic, Isidora Neskovic, Karolina Vukoje, Snezana Brkic
Summary: This study compared salivary and plasma MDA levels in periodontitis patients with healthy controls and evaluated the effectiveness of periodontal therapy. The results showed higher levels of salivary and plasma MDA in the periodontitis group, and a significant decrease in salivary MDA levels after periodontal therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Organic
Min Peng, Quan-Rong Du, Xue Yao, Chun-Ni Li, Yang Tian, Yu Peng, Ya-Wen Wang
Summary: A simple fluorescein derivative was synthesized as a fluorescent probe for detecting malondialdehyde (MDA). The probe achieved ring-opening of fluorescein and formation of a benzohydrazide derivative through a synergistic reaction. It exhibited high sensitivity and selectivity for MDA detection, and could quickly and visually detect MDA within 60 s using UV-vis and fluorescent modes. Moreover, the probe showed excellent performance in imaging MDA in living cells and bacteria.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Medicine, General & Internal
Fanwen Jiang, Lin Zhou, Chun Zhang, Hui Jiang, Zhuping Xu
Summary: This systematic review compared circulating malondialdehyde (MDA) levels in people with and without diabetic retinopathy (DR). The results showed that circulating MDA levels were higher in people with DR compared to those without.
CHINESE MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Elisabetta Zinellu, Sara S. Fois, Barbara Piras, Gianfranco Pintus, Ciriaco Carru, Arduino A. Mangoni, Alessandro G. Fois, Angelo Zinellu, Pietro Pirina
Summary: The study found that the MDA concentrations were significantly higher in patients with obstructive sleep apnea (OSA) compared to controls, indicating that MDA may be involved in the pathogenesis of OSA and providing insights for future research on its potential clinical use.
Review
Biochemistry & Molecular Biology
Niloufar Rasaei, Omid Asbaghi, Mahsa Samadi, Leila Setayesh, Reza Bagheri, Fatemeh Gholami, Neda Soveid, Krista Casazza, Alexei Wong, Katsuhiko Suzuki, Khadijeh Mirzaei
Summary: Green tea supplementation has significant effects on total antioxidant capacity (TAC) in adults, with heterogeneity between studies related to gender and BMI. Meta-regression analysis suggests a linear inverse association between the dosage of green tea and significant change in malondialdehyde (MDA). Further research is needed to validate these findings.
Article
Biochemistry & Molecular Biology
Maud Hemmendinger, Jean-Jacques Sauvain, Nancy B. Hopf, Pascal Wild, Guillaume Suarez, Irina Guseva Canu
Summary: The study optimized a method based on 2,4-dinitrophenylhydrazine for quantifying MDA in EBC, with analytical uncertainty at the LOQ level reaching 23%, yet still lower than the observed inter-individual variability.
Article
Pediatrics
Gopal Agrawal, Sourabh Dutta, Rajendra Prasad, Mangat Ram Dogra
Summary: Fetal oxidative stress and micronutrient deficiencies are associated with retinopathy of prematurity, with high MDA levels and low micronutrients in cord and maternal blood being predictors of ROP.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Veterinary Sciences
Ana Patricia Alves Leao, Alexandre Vinhas de Souza, Nelson Fijamo Mesquita, Luciano Jose Pereira, Marcio Gilberto Zangeronimo
Summary: This systematic review evaluated the potential benefits of antioxidant enrichment of rooster semen extenders. The findings suggest that antioxidants can reduce oxidative stress and improve fertilizing capacity for roosters.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Food Science & Technology
Mojgan Morvaridzadeh, Shahram Agah, M. Dulce Estevao, Ava Sadat Hosseini, Hafez Heydari, Omid Toupchian, Shima Abdollahi, Emma Persad, Ahmed Abu-Zaid, Gholamreza Rezamand, Javad Heshmati
Summary: Studies have shown that saffron supplementation can significantly decrease malondialdehyde levels and increase total antioxidant capacity in unhealthy patients, indicating its beneficial properties in improving oxidative stress. However, additional randomized controlled trials are needed to evaluate the effects on other oxidative stress parameters.
FOOD SCIENCE & NUTRITION
(2021)
Review
Food Science & Technology
Sanaz Rezaei Zonooz, Motahareh Hasani, Mojgan Morvaridzadeh, Ana Beatriz Pizarro, Hafez Heydari, Somaye Yosaee, Gholamreza Rezamand, Javad Heshmati
Summary: The study demonstrated that alpha-lipoic acid supplementation significantly reduced Malondialdehyde (MDA) levels, but had no significant effect on other antioxidant enzymes and oxidative stress parameters. Overall, it suggested that alpha-lipoic acid supplementation might improve lipid peroxidation, and recommended a daily intake of less than 800 mg for controlling lipid peroxidation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agricultural Engineering
Mahsa Khatooni, Hassan Karimmojeni, Ali Gholami Zali, Jamshid Razmjoo, Te-Ming Tseng
Summary: This study investigated the effects of salicylic acid (SA) and bentazon on valerian. The results showed that exogenous application of SA positively impacted bentazon-exposed plants, reducing phytotoxicity damage and enhancing antioxidant enzyme system.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Clinical Neurology
Enrico Capuzzi, Paolo Ossola, Alice Caldiroli, Anna Maria Auxilia, Massimiliano Buoli
Summary: This study critically summarized the available data about MDA as a candidate biomarker for BD, finding that bipolar patients experience more oxidative stress than healthy subjects and that treatment is effective in reducing MDA levels. Age, gender, and mood episode significantly influenced MDA levels in patients with BD. Further studies are needed for definitive conclusions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Arturo Lopez-Yanez Blanco, Keyla M. Diaz-Lopez, Jenny Vilchis-Gil, Hector Diaz-Garcia, Jacqueline Gomez-Lopez, Patricia Medina-Bravo, Javier T. Granados-Riveron, Juan M. Gallardo, Miguel Klunder-Klunder, Rocio Sanchez-Urbina
Summary: Overweight and obesity are global public health problems, especially in developing countries. Maternal pregestational overweight or obesity is associated with higher levels of oxidative stress markers in mother-newborn pairs. Higher intake of fruits and vegetables in diet is associated with lower levels of NO and MDA.
Article
Biochemistry & Molecular Biology
Afoon Talaie, Hanieh Jafary, Fardin Faraji, Ali Akbar Malekirad
Summary: This study found that migraine patients had lower serum selenium levels and higher MDA levels, while TAC levels were not significantly different compared to healthy individuals. The lower selenium and higher MDA levels were significantly associated with migraine, indicating that oxidative stress may play an important role in the pathogenesis of migraine.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Hematology
Philippe Connes, Berenike Mockesch, Emilienne Tudor Ngo Sock, Marie-Dominique Hardy-Dessources, Karen Reminy, Sarah Skinner, Marie Billaud, Elie Nader, Benoit Tressieres, Maryse Etienne-Julan, Nicolas Guillot, Nathalie Lemonne, Olivier Hue, Marc Romana, Sophie Antoine-Jonville
Summary: The study compared plasma markers of inflammation and oxidative stress, as well as microvascular function, between patients with sickle cell disease of different genotypes and under hydroxyurea (HU) treatment or not. Results showed that oxidative stress and inflammation were lower in HbSC patients and HbSS patients receiving HU treatment compared to HbSS patients not treated with HU.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Sarah Skinner, Elie Nader, Emeric Stauffer, Melanie Robert, Camille Boisson, Agnes Cibiel, Clement Foschia, Leonard Feasson, Paul Robach, Guillaume Y. Millet, Philippe Connes
Summary: This study showed that a 171 km ultra-trail race results in greater modulations in cytokine profiles than a traditional trail race. Both races led to significant increases in leukocyte concentrations, but certain cytokines showed more significant changes after the ultra-trail race.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Acoustics
Cyril Lafon, David Moore, Matthew D. C. Eames, John Snell, Robert Andrew Drainville, Frederic Padilla
Summary: Transcranial high-intensity focused ultrasound is a promising treatment for brain disorders, but high energy can lead to undesired cavitation. This study evaluated the use of gated sonication to increase cavitation threshold and assessed heating capabilities. Results showed that gated sonication required higher pressure levels for cavitation initiation after propagation through a human skull and resulted in lower cavitation activity compared to continuous sonication. Additionally, heating capabilities were not affected by gated sonication, making it a potential alternative to continuous sonication when cavitation onset is a concern.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Acoustics
Jade Robert, Francis Bessiere, Elodie Cao, Virginie Loyer, Emma Abell, Fanny Vaillant, Bruno Quesson, Stefan Catheline, Cyril Lafon
Summary: This study introduces a novel method to characterize cardiac activation based on the time evolution and instantaneous frequency content. The method was validated on an ex vivo dataset and successfully implemented on animals during experiments to map cardiac activation.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Review
Oncology
Maxime Lafond, Thomas Lambin, Robert Andrew Drainville, Aurelien Dupre, Mathieu Pioche, David Melodelima, Cyril Lafon
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer with poor prognosis. Focused ultrasound is an emerging therapy that shows promising potential in treating PDAC. This review provides an overview of the clinical application and scientific research of therapeutic focused ultrasound for PDAC, summarizing its current benefits, challenges, and future directions.
Article
Acoustics
Myleva Dahan, Marion Cortet, Cyril Lafon, Frederic Padilla
Summary: This review summarizes the latest research progress in the treatment of breast cancer and evaluates the potential of combining therapeutic ultrasound with other treatment modalities.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Sport Sciences
Alexandre Foure, Thibault Besson, Emeric Stauffer, Sarah C. Skinner, Jeremie Bouvier, Leonard Feasson, Philippe Connes, Christophe A. Hautier, Guillaume Y. Millet
Summary: The purpose of this study was to assess sex-related differences in resting mechanical properties and adaptations of skeletal muscles and tendons in response to trail running races of different distances. The results showed that the mechanical properties of muscles and tendons are affected by sex, and adaptations to the races are related to running distance.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Editorial Material
Urology & Nephrology
Vimal K. Derebail, Jing Zhu, Matthew L. Crawford, Julia R. Garnier, Karlyn A. Martin, Sarah Skinner, Tejendra Patel, Anne Froment, Margaret R. Sketch, Andy H. Szeto, Sheel M. Patel, Chad D. Torrice, Stefan Tiefenbacher, Dorothy M. Adcock, Russell P. Grant, Nigel S. Key, Daniel J. Crona
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wafae Labriji, Julien Clauzel, Jean-Louis Mestas, Maxime Lafond, Cyril Lafon, Anne-Sophie Salabert, Lydiane Hirschler, Jan M. Warnking, Emmanuel L. Barbier, Isabelle Loubinoux, Franck Desmoulin
Summary: The purpose of this study was to investigate the effect of Blood Brain Barrier (BBB) opening using ultrasound combined with microbubbles injection on cerebral blood flow in rats. The results showed that BBB opening induced by microbubble intravenous injection led to transient hypoperfusion, which shared some similarities with cortical spreading depression phenomenon.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biochemical Research Methods
Sarah C. Skinner, Travis Nemkov, Mor Diaw, Maimouna Ndour Mbaye, Demba Diedhiou, Djiby Sow, Fatou Gueye, Philomene Lopez, Philippe Connes, Angelo D'Alessandro
Summary: Epidemiological data suggests that the prevalence of type 2 diabetes (T2D) will increase the most in sub-Saharan Africa over the next two decades. Metabolomics studies have identified biomarkers that could enhance T2D diagnosis and monitoring. However, there is a lack of research on the metabolome of individuals from sub-Saharan Africa.
JOURNAL OF PROTEOME RESEARCH
(2023)
Editorial Material
Surgery
Sarah Skinner, Antoine Duclos
Summary: This viewpoint describes how surgeons can improve their performance by applying continuous performance improvement methods used by athletes.
Article
Physics, Applied
A. Ganeau, M. Lafond, F. Legrand, G. Laloy-Borgna, O. Ben Moussa, S. Poinard, F. Mascarelli, G. Thuret, P. Gain, C. Lafon, S. Catheline
Summary: This study characterizes the viscoelastic properties of in vitro crystalline lens samples using a curvilinear harmonic method based on noise correlation algorithms. The study observes the dispersion of surface waves at different frequencies and provides accurate measurements of shear elasticity and viscosity. The findings have implications for potential treatments of presbyopia.
APPLIED PHYSICS LETTERS
(2023)
Article
Acoustics
Robert Andrew Drainville, Sylvain Chatillon, David Moore, John Snell, Frederic Padilla, Cyril Lafon
Summary: This study investigates how imprecision in model inputs affects the quality of acoustic focusing through the skull using a ray-tracing simulation model. New methods to optimize ray-tracing skull simulations for clinical treatment planning are proposed and validated using experimental data from ex-vivo human skulls.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Health Care Sciences & Services
Sarah Skinner, Lea Pascal, Stephanie Polazzi, Francois Chollet, Jean-Christophe Lifante, Antoine Duclos, SHEWHART Trial Grp
Summary: Implementing surgical outcome monitoring using control charts can reduce hospital bed-days and healthcare costs within 30 days following surgery.
BMJ QUALITY & SAFETY
(2023)
Review
Urology & Nephrology
Sarah C. Skinner, Vimal K. Derebail, Caroline J. Poulton, Donna C. Bunch, Prabir Roy-Chaudhury, Nigel S. Key
Summary: Individuals receiving long-term hemodialysis are at increased risk of cardiovascular disease, with traditional risk factors unable to fully explain the elevated risk. The interaction between blood and the biomaterials during hemodialysis can activate the complement system and coagulation pathways. Activation of these systems may contribute to the pathogenesis and progression of cardiovascular disease in this population.