Journal
ULTRASONICS SONOCHEMISTRY
Volume 24, Issue -, Pages 1-7Publisher
ELSEVIER
DOI: 10.1016/j.ultsonch.2014.12.006
Keywords
Ultrasonic irradiation; 2-Amino-3-cyano-4H-pyrans; Multi-component reactions; Heteroaryl aldehydes; Malononitrile; Active methylene compounds
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Funding
- VGST, Dept. of IT, BT and Science & Technology, Government of Karnataka for the CESEM Award [24 (2010-2011)]
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An efficient synthesis of a novel series of twelve substituted 2-amino-3-cyano-4H-pyran derivatives was achieved by a one-pot three-component cyclocondensation reaction of heteroaryl aldehydes, malononitrile and active methylene compounds catalyzed by iodine in aqueous medium under ultrasound irradiation. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness. We have herein successfully demonstrated the synergistic outcome of multi-component reaction (MCR) and sonication to offer a facile route for the design of these derivatives. (C) 2014 Elsevier B.V. All rights reserved.
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