4.3 Article

Multiscale Functional and Molecular Photoacoustic Tomography

Journal

ULTRASONIC IMAGING
Volume 38, Issue 1, Pages 44-62

Publisher

SAGE PUBLICATIONS INC
DOI: 10.1177/0161734615584312

Keywords

photoacoustic tomography; photoacoustic microscopy; photoacoustic computed tomography; multiscale imaging; functional imaging; molecular imaging

Funding

  1. NIH [DP1 EB016986, R01 CA186567, U01 NS090579]
  2. NATIONAL CANCER INSTITUTE [R01CA186567] Funding Source: NIH RePORTER
  3. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [DP1EB016986] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U01NS090579] Funding Source: NIH RePORTER

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Photoacoustic tomography (PAT) combines rich optical absorption contrast with the high spatial resolution of ultrasound at depths in tissue. The high scalability of PAT has enabled anatomical imaging of biological structures ranging from organelles to organs. The inherent functional and molecular imaging capabilities of PAT have further allowed it to measure important physiological parameters and track critical cellular activities. Integration of PAT with other imaging technologies provides complementary capabilities and can potentially accelerate the clinical translation of PAT.

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