Journal
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
Volume 392, Issue 10, Pages 2415-2425Publisher
ELSEVIER
DOI: 10.1016/j.physa.2013.01.047
Keywords
Tumor model; Cancer growth; Immunotherapy; Lymphocytes; Cell blockade
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Funding
- SECyT-UNC
- ANPCyT [PICT 2205/33675]
- CONICET (Argentina) [PIP 6311/05]
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A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact. (C) 2013 Elsevier B.V. All rights reserved.
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