Review
Engineering, Biomedical
Ana Waleska Pessoa Barros, Pedro Henrique da Hora Sales, Paulo Goberlanio de Barros Silva, Ana Claudia Amorim Gomes, Alessandra Albuquerque Tavares Carvalho, Jair Carneiro Leao
Summary: This systematic review aimed to evaluate the effectiveness of low-level laser therapy in treating herpes labialis. The findings showed that low-level laser therapy significantly reduced tissue healing time, but had no significant effect on crust formation time. However, due to the high risk of bias in the included studies, more standardized research is needed to prove the effectiveness of this therapy.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Oncology
Karen Muller Ramalho, Sandra Ribeiro Cunha, Flavia Goncalves, Gustavo Silva Escudeiro, Carolina Steiner-Oliveira, Anna Carolina Rato Tempestini Horliana, Carlos de Paula Eduardo
Summary: The study compared photodynamic therapy, topical acyclovir, and the combination of both in the treatment of herpes simplex virus type 1 recurrences. It was found that on day 1, photodynamic therapy showed better results in treating herpes lesions compared to acyclovir.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Surgery
Marwa Khalil, Omar Hamadah
Summary: This systematic review analyzes the effectiveness of combining photodynamic therapy (PDT) and photobiomodulation (PBM) in treating recurrent herpes labialis. Despite variations in parameters, all case reports showed positive results in relieving symptoms, accelerating healing, and reducing recurrence without side effects.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2022)
Article
Oncology
Muhammed Ajmal
Summary: The clinical trial assessed the effectiveness of photodynamic therapy in combination with topical acyclovir for herpes labialis in adolescent patients. The results showed that topical antiviral therapy with adjunctive PDT significantly reduced pain and proinflammatory markers in adolescent patients with herpes labialis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Sandro Roberto de Araujo, Diego Filipe Bezerra Silva, Isabella Jardelino Dias, Rodrigo Queiroga de Moura, Jozinete Vieira Pereira, Daliana Queiroga de Castro Gomes
Summary: This study successfully treated a 21-year-old male patient with recurrent herpes using photodynamic therapy and photobiomodulation, with no recurrence observed during the follow-up period of eight months.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pasquale Santamaria, Ruth C. E. Bowyer, Luigi Nibali
Summary: This study aimed to explore the role of host genetic factors in the reactivation of Herpes Simplex Labialis (HSL). The findings suggest that a single nucleotide polymorphism in the Vitamin D Receptor (VDR) gene may be associated with the occurrence and recurrence of cold sores.
ARCHIVES OF ORAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xingyu Long, Xiaojie Zhang, Qiaohui Chen, Min Liu, Yuting Xiang, Yuqi Yang, Zuoxiu Xiao, Jia Huang, Xiaoyuan Wang, Chong Liu, Yayun Nan, Qiong Huang
Summary: This article comprehensively summarizes recent advances in nucleus-targeting phototherapy, classifying it into three categories and providing insights and prospects for future developments. This mini-review provides unique insights and valuable clues in the design of phototherapy nanodrugs and other nucleus-targeting drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Pradeep Chopra, Tejabhiram Yadavalli, Francesco Palmieri, Seino A. K. Jongkees, Luca Unione, Deepak Shukla, Geert-Jan Boons
Summary: Inhibition of human heparanase (Hpse) has been found to be a promising therapeutic strategy for preventing the spread of herpes simplex virus (HSV-1). The synthesis of hexa- and octasaccharide inhibitors of Hpse showed potent enzyme inhibition and the presence of 2-O-sulfation on iduronic acid was tolerated. These inhibitors not only blocked viral-induced shedding of cell-surface heparan sulfate (HS) but also inhibited cell migration and proliferation in corneal epithelial cells infected with HSV-1.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Nicolo Bordignon, Mariana Kober, Giorgia Chinigo, Carlotta Pontremoli, Ettore Sansone, Guillem Vargas-Nadal, Maria Jesus Moran Plata, Alessandra Fiorio Pla, Nadia Barbero, Judit Morla-Folch, Nora Ventosa
Summary: Photodynamic therapy is a non-invasive therapeutic strategy that uses external light and a photosensitizer to destroy abnormal cells. The main challenges in this therapy are the photosensitivity, hydrophobicity, and tumor target avidity of the photosensitizer. In this study, brominated squaraine was successfully incorporated into Quatsome nanovesicles to overcome the solubility limitation and maximize the PDT effectiveness. This approach allows for a lower concentration of squaraine compared to traditional PDT, making it a promising photosensitizer for PDT.
Review
Pharmacology & Pharmacy
Stefano Caccavale, Vittorio Tancredi, Paola Vitiello, Antonello Sica, Andrea Ronchi, Renato Franco, Francesco Pastore, Giuseppe Argenziano
Summary: Topical photodynamic therapy (PDT) is a promising treatment option for cutaneous lymphomas, with good tolerability and cosmetic outcomes. However, its mechanism of action and efficacy in treating lymphoproliferative diseases are still not well understood. Further clinical trials are needed to determine the optimal treatment protocol.
Article
Pharmacology & Pharmacy
Adrienn Kazsoki, Barnabas Palcso, Alan Alpar, Robert Snoeck, Graciela Andrei, Romana Zelko
Summary: By formulating core-shell type nanofibrous scaffolds loaded with dexpanthenol and acyclovir, this project explored a new direction for treating herpes labialis. The electrospun fibers showed promising results in terms of morphology, physicochemical properties, and antiviral activity, releasing acyclovir and dexpanthenol within 20 minutes and demonstrating better antiviral activity compared to leading commercial creams.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Wangxing Lu, Wenjie Liu, Anna Hu, Jian Shen, Hanxi Yi, Zeneng Cheng
Summary: PDA@Lipo/DOX/ICG is a multifunctional nanoplatform based on PDA-coated liposomes for accurate and efficient combinatorial cancer therapy of chemotherapy and laser-induced PDT/PTT.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Haixing Lin, Runhong Zhou, Taojing Yu, Jian He
Summary: The heterogeneity of tumor cells and the protective effects of cell membranes hinder targeted tumor therapy. A new acid-targeting peptide showed high affinity to tumor cell membranes in an acidic environment, indicating its potential as a delivery system for targeting solid tumor cells.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Oncology
Takaaki Tsuchida, Yuji Matsumoto, Tatsuya Imabayashi, Keigo Uchimura, Shinji Sasada
Summary: This study confirmed the safety of Talaporfin-PDT as a day treatment for CELC. It showed positive results in terms of safety and effectiveness for the treatment of CELC.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Medicinal
Amanda F. Silva-Alvarez, Ana Clara Wada de Carvalho, Erica Benassi-Zanqueta, Thalita Z. Oliveira, Dyenefer P. Fonseca, Maira P. Ferreira, Fabiana T. M. C. Vicentini, Tania Ueda-Nakamura, Vinicius Pedrazzi, Osvaldo de Freitas
Summary: This study developed formulations containing anesthetics for the treatment of mucocutaneous infections caused by Herpes simplex virus. The formulations were able to reduce pain, show antiviral properties, and were proven effective in in vivo tests.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alana Cristina Machado, Vinicius Maximiano, Mirian Lumi Yoshida, Julia Gomes Freitas, Fausto Medeiros Mendes, Ana Cecilia Correa Aranha, Tais Scaramucci
Summary: This study compared the efficacy of two treatments for dentin hypersensitivity, showing that the ionomeric sealant (IS) was the most effective in the short term and also had better long-term results compared to Ca/PO4(-)/F- varnish. The results indicated that IS can significantly reduce DH symptoms, while the varnish did not show significant differences compared to the placebo.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Oncology
Gabriela Alves da Collina, Fernanda Viana Cabral, Carolina Montovam Monteiro, Gabriela Benedito Machado, Jose Marcelo Lacerda Alves Goncalves, Fernanda Freire, Renato Araujo Prates, Martha Simoes Ribeiro, Christiane Pavani
Summary: This study evaluated the photodynamic inactivation (PDI) effects of an oral formulation (OF) containing 0.005% methylene blue (MB) on Candida albicans biofilm using multiple methodologies. The results showed that PDI mediated by MB-OF significantly reduced the colony forming units (CFU) and virulence of the biofilm, but did not have a significant impact on metabolic activity. The crystal violet (CV) staining data were inconclusive due to interference from the components of the formulation.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Wladimir Gushiken de Campos, Camilla Vieira Esteves, Camila de Barros Gallo, Carina Domaneschi, Ana Cecilia Correa Aranha, Celso Augusto Lemos
Summary: This study evaluated the outcomes of CO2 laser treatment for oral leukoplakia and found that the treatment was effective in removing the lesions but did not completely prevent relapse or malignant transformation. Among the 37 patients in the study, 13 experienced recurrence of leukoplakia and 8 had malignant transformation.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Carla Daruich de Souza, Angelica Bueno Barbezan, Wilmmer Alexander Arcos Rosero, Sofia Nascimento dos Santos, Diego Vergacas de Sousa Carvalho, Carlos Alberto Zeituni, Emerson Soares Bernardes, Daniel Perez Vieira, Patrick Jack Spencer, Martha Simoes Ribeiro, Maria Elisa Chuery Martins Rostelato
Summary: This study describes a method for synthesizing radioactive Gold-198 nanoparticles without the use of surfactants. The results demonstrate the effectiveness of these nanoparticles in both in vitro and in vivo experiments.
Article
Biochemistry & Molecular Biology
Caetano P. Sabino, Martha S. Ribeiro, Mark Wainwright, Carolina Dos Anjos, Fabio P. Sellera, Milena Dropa, Nathalia B. Nunes, Guilherme T. P. Brancini, Gilberto U. L. Braga, Victor E. Arana-Chavez, Raul O. Freitas, Nilton Lincopan, Mauricio S. Baptista
Summary: The uncontrolled spread of multidrug-resistant pathogens is a major global health threat. Antimicrobial photodynamic therapy (aPDT) offers a promising approach to treating localized infections without being limited by drug resistance. In this study, various techniques were used to investigate the biochemical mechanisms of aPDT. The results suggest that protein degradation correlates with microbial inactivation kinetics, providing important insights for the development of optimized photosensitizing drugs and combination therapies with antimicrobial chemotherapy.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tania M. Yoshimura, Fernanda Cabral, Fabio P. Sellera, Lorena Pozzo, Martha S. Ribeiro
Summary: This article systematically reviews the impact of combining stem cell and photobiomodulation therapy (PBM) in the repair of skin wounds. The meta-analysis shows that the combination of SCs and PBM has a positive influence on wound closure and strength, although there is heterogeneity and bias in the included studies.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Bruno L. Raposo, Sueden Souza, Gleyciane S. Santana, Max T. A. Lima, Jose F. Sarmento-Neto, Julio S. Reboucas, Goreti Pereira, Beate S. Santos, Paulo E. Cabral Filho, Martha S. Ribeiro, Adriana Fontes
Summary: Researchers proposed a novel method of using polyvinylpyrro-lidone (PVP) coated silver nanoparticles (AgNPs) in combination with cationic Zn(II) porphyrins (ZnPs) for photodynamic inactivation (PDI) of Candida albicans infections. The AgNPs-ZnPs system achieved complete eradication of Candida albicans at lower porphyrin concentrations, reducing the risk of antifungal drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Optics
Fernanda V. Cabral, Tania M. Yoshimura, Daniela De Fatima Teixeira da Silva, Mauro Cortez, Martha S. Ribeiro
Summary: Photodynamic therapy (PDT) mediated by methylene blue (MB) has shown potential in treating cutaneous leishmaniasis, as it can overcome drug resistance and effectively destroy the parasite.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2023)
Article
Oncology
G. A. Novaes, M. H. Blank, T. M. Yoshimura, M. S. Ribeiro, R. J. G. Pereira
Summary: Artificial insemination in poultry often leads to high levels of bacterial contamination in the semen. This study explored the potential use of antimicrobial photodynamic therapy (PDT) as an alternative to antibiotics in preserving semen quality. The results showed that incubation with methylene blue (MB) did not affect sperm motility, but increasing light dose during the PDT process resulted in greater reductions in sperm parameters. However, the conditions that were less harmful to spermatozoa were not effective in reducing bacterial colonies in chicken semen.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Jesica A. Dimmer, Fernanda V. Cabral, Susana C. Nunez Montoya, Martha S. Ribeiro
Summary: This study investigated the potential of three natural anthraquinones on cutaneous leishmaniasis induced by Leishmania amazonensis. The results showed that G5ClSor-gL was able to sustain low levels of parasite burden over time, and GSor-bL inhibited disease progression, demonstrating their potential as promising compounds for treating the disease.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Microbiology
Carolina dos Anjos, Leon G. Leanse, Martha S. Ribeiro, Fabio P. Sellera, Milena Dropa, Victor E. Arana-Chavez, Nilton Lincopan, Mauricio S. Baptista, Fabio C. Pogliani, Tianhong Dai, Caetano P. Sabino
Summary: Antimicrobial drug development is under scrutiny due to the worldwide antibiotic crisis. Antimicrobial blue light (aBL) has been recognized as a potential therapy for infections, but the specific targets for bacterial killing by aBL are still poorly understood and may vary depending on the bacterial species.
MICROBIOLOGY SPECTRUM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lucia Kottmann, Rene Franzen, Georg Conrads, Stefan Wolfart, Juliana Marotti
Summary: This study aimed to evaluate the effectiveness of an Er,Cr:YSGG laser with side-firing tip in decontaminating titanium discs. The results showed that Perioflow and the Er,Cr:YSGG laser had similar efficacy in decontamination.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
Article
Pharmacology & Pharmacy
Fernanda V. Cabral, Bianca de Melo Santana, Camila N. Lange, Bruno L. Batista, Amedea B. Seabra, Martha S. Ribeiro
Summary: This study investigated the potential of polymeric hydrogels in the treatment of melanoma. The researchers found that hydrogels containing both a nitric oxide donor and copper oxide nanoparticles significantly reduced cell viability and increased reactive oxygen species levels. They also observed changes in cell nuclei, loss of mitochondrial membrane potential, and lipid peroxidation, leading to cell death.
Article
Microbiology
Abdenego R. Silva, Fernanda V. Cabral, Camila R. Silva, Daniela F. T. Silva, Anderson Z. Freitas, Adriana Fontes, Martha S. Ribeiro
Summary: This study evaluated the impact of photodynamic inactivation mediated by methylene blue (MB-PDI) or 1,9-dimethyl MB (DMMB-PDI) combined with a red LED against the hospital-acquired pathogen C. auris. DMMB-PDI successfully eradicated C. auris, while MB only killed cells when exposed to the highest light dose. DMMB-PDI promoted higher levels of reactive oxygen species, lipid peroxidation, and mitochondrial membrane potential compared to MB. Additionally, DMMB-PDI was able to inhibit biofilm formation and destroy mature biofilms, with no toxicity observed in fibroblasts. We conclude that DMMB-PDI holds great potential to combat the global threat posed by C. auris.
Article
Multidisciplinary Sciences
Fernanda V. Cabral, Michela Cerone, Saydulla Persheyev, Cheng Lian, Ifor D. W. Samuel, Martha S. Ribeiro, Terry K. Smith
Summary: The emergence of drug resistance in cutaneous leishmaniasis has become a major problem. Photodynamic therapy has shown effectiveness against drug-resistant strains and may be an attractive strategy for treatment.