Article
Medicine, Research & Experimental
Sajan George, Loredana Serpe
Summary: Despite efforts in biomedical research, cancer remains a major global health problem. Novel treatment paradigms, such as using non-thermal low-intensity focused ultrasound (LIFU) to condition cancer cells, could lead to significant progress in anticancer therapy with fewer side effects.
Article
Plant Sciences
Ido Rog, Amit Kumar Chaturvedi, Vivekanand Tiwari, Avihai Danon
Summary: The study demonstrates that Arabidopsis PTOX contains a conserved C-terminus domain with cysteines that can rapidly switch states in response to light conditions, suggesting a crucial role in the adaptation of plants to terrestrial environments.
Article
Plant Sciences
Mingli Xu, Tieqiang Hu, R. Scott Poethig
Summary: Plants grown under low light intensity display shade tolerance syndrome due to the transcriptional and post-transcriptional repression of miR156-regulated SPL genes, which are associated with prolonged juvenile vegetative phase and changes in carbohydrate production. The response of Arabidopsis to low light intensity is mediated by an increase in miR156/miR157 expression and factors that repress SPL gene expression independently of miR156/miR157, showing that rosette development is regulated through different pathways than shade avoidance syndrome.
Article
Biochemistry & Molecular Biology
Renate Viebahn-Haensler, Olga Sonia Leon Fernandez
Summary: Low-dose ozone can act as a bioregulator in chronic inflammatory diseases by improving oxidative stress and redox signaling. It works through two mechanisms: direct for topical treatments and indirect for systemic treatments, providing potential benefits in regulating antioxidants and modulating cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Chemical
Ailton Guilherme Rissoni Toledo, Rachel Biancalana Costa, Tiago Palladino Delforno, Fabiana Antonia Arena, Denise Bevilaqua
Summary: This study investigated the bioleaching of chalcopyrite using microbial consortia under thermophilic conditions. The results indicated that chalcopyrite is initially reduced to chalcocite followed by its dissolution. Microbial activity played a crucial role in lowering the solution potential, allowing the prevalence of the chalcocite mechanism.
MINERALS ENGINEERING
(2023)
Article
Business
Nur Baiti Ingga Wulandhari, Ismail Golgeci, Nishikant Mishra, Uthayasankar Sivarajah, Suraksha Gupta
Summary: This research contributes to the understanding of cooperative resilience by examining how social foundations can facilitate the assembly of resilience capabilities, shedding light on social capital mechanisms that underlie diverse sets of resilience capabilities in cooperatives.
JOURNAL OF BUSINESS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nikolaos Koumallos, Evangelia Sigala, Theodoros Milas, Nikolaos G. Baikoussis, Dimitrios Aragiannis, Skevos Sideris, Konstantinos Tsioufis
Summary: This article summarizes extensive research on the crucial role of the Renin-Angiotensin System (RAS) in hypertension, cardiovascular disorders, and renal diseases, as well as the established role of oxidative stress in vascular balance. It further explores the interaction between reactive oxygen species (ROS) and RAS in the physiology of human blood vessels, and examines the mechanisms by which clinical interventions targeting RAS affect redox signaling in the vascular wall.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Jun Liu, Marc W. van Iersel
Summary: The study demonstrates that green light has lower photosynthetic efficiency at low light intensity, while it may have higher efficiency at high light intensity compared to red and blue light, due to its more uniform absorption throughout the leaves.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Emily Sutterby, Chanly Chheang, Peter Thurgood, Khashayar Khoshmanesh, Sara Baratchi, Elena Pirogova
Summary: Photobiomodulation (PBM) utilizes light to modulate cellular processes, and shows potential benefits in wound healing and pain reduction. However, the molecular mechanisms underlying PBM's effects are not fully understood. This study developed a custom-made LED-based exposure system to study the effects of very low-intensity visible light on skin cells. The results demonstrate increased proliferation and mitochondrial activity with red light exposure. This research provides insights into the complex cellular mechanisms driven by visible light irradiation of skin cells.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Xiaoting Zhou, Biao An, Yi Lin, Yanghong Ni, Xia Zhao, Xiao Liang
Summary: Drug resistance is a major obstacle in curing cancer patients. Reactive oxygen species (ROS) play a crucial role in modulating drug resistance in cancer cells, with higher levels seen in drug-resistant cells compared to non-resistant cells. Understanding the functions of ROS in drug resistance can help develop therapies to sensitize cancer cells. This review summarizes literature on ROS production, regulation, and their complex roles in cancer chemoresistance, including transcription factor-mediated resistance and impact on the tumor microenvironment. The potential of ROS-targeted therapies in overcoming therapeutic resistance is also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Jiaqi Si, Guofeng Zhao, Tian Lan, Jiayong Ni, Weidong Sun, Ye Liu, Yong Lu
Summary: The study reveals that Na2WO4 plays a crucial role in reducing the trigger temperature and selectively activating the Mn7SiO12 <-> MnSiO3 redox reaction in the OCM process. It also shows that oxygen exchange between O2 and Na2WO4 only occurs in case of re-oxidizing MnWO4 formed during the reaction at high temperatures.
Review
Chemistry, Multidisciplinary
Pankaj Kumar, Vyom Prakash Tyagi, Munmun Ghosh
Summary: In recent years, researchers have focused on investigating the redox properties of ancillary ligand backbones for small-molecule activation. Metal complexes have been used for the electrocatalytic H2 evolution reaction (HER), providing insights into the coupling of electrons and protons. Redox-active ligands facilitate electron transfer and promote effective orbital overlap, enabling efficient proton-coupled electron transfer reactions. Thorough spectroscopic and computational analyses are necessary for understanding catalytic mechanisms. This review summarizes recent examples of molecular electrocatalysts based on 3d transition metals and highlights the role of metal-ligand cooperativity in mechanistic pathways.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Jiaqi Si, Guofeng Zhao, Tian Lan, Jiayong Ni, Weidong Sun, Ye Liu, Yong Lu
Summary: The role of Na2WO4 in a Mn7SiO12-Na2WO4/Cristobalite catalyst system was investigated. Na2WO4 was found to modulate the redox cycle of Mn7SiO12<->MnSiO3 by reducing the trigger temperature, thus selectively promoting the oxidative coupling of CH4. No direct redox of Na2WO4 or oxygen spillover between Na2WO4 and Mn7SiO12 was observed.
Article
Chemistry, Multidisciplinary
Kexin Bian, Weitao Yang, Yan Xu, Weiwei Zeng, Hui Wang, Hongying Liang, Tianming Cui, Zhuo Wang, Bingbo Zhang
Summary: This study demonstrates the importance of the reduction potential state of sonosensitizers in reactive oxygen species (ROS) generation. The reduction potential of band-edge is found to be critical, especially when aligned with the reduction of oxygen. Additionally, ultrasound-generated oxidation holes are effective in consuming overexpressed glutathione, enhancing cellular oxidative stress and inducing tumor cell death. The intrinsic fluorescence property of semiconductors provides imaging capability and guides the sonodynamic therapy (SDT) process.
Review
Engineering, Biomedical
Yilong Guo, Qian Qu, Jian Chen, Yong Miao, Zhiqi Hu
Summary: LLLT has been shown to accelerate hair growth in AGA patients, with proposed mechanisms including the production of NO and modulation of ROS through low-level light absorption, leading to the activation of signaling pathways in hair follicle cells and perifollicular cells. While the efficacy of LLLT in treating AGA has been confirmed, more systematic studies are needed to standardize treatment parameters and ensure long-term safety and efficacy. Additionally, current understandings of LLLT mechanisms should shift focus towards different cellular components in the hair follicle microenvironment.
LASERS IN MEDICAL SCIENCE
(2021)