Article
Ophthalmology
Keiko Azuma, Yoko Nomura, Kohdai Kitamoto, Yohei Hashimoto, Ryosuke Fujino, Kohei Ueda, Tatsuya Inoue, Ryo Obata
Summary: This study characterized the findings of eyes with choroidal vascular hyperpermeability (CVH) using multimodal imaging. It found that near-infrared autofluorescence imaging can accurately identify the location of CVH.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Maciej Gawecki, Andrzej Grzybowski
Summary: This study aimed to determine the deficit of best corrected visual acuity (BCVA) and individual retinal layers in different types of central serous chorioretinopathy (CSCR), with reference to its duration. The results showed that BCVA values were significantly lower in acute and chronic cases, and the thickness of all retinal layers and macular volume were significantly decreased in chronic eyes. The deficit in retinal layers was strongly correlated with poorer BCVA and disease duration.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Enrico Borrelli, Marco Battista, Francesco Gelormini, Maria C. Gabela, Flavia Pennisi, Alberto Quarta, Mario Pezzella, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to evaluate the photoreceptor structural changes in the unaffected fellow eyes of unilateral central serous chorioretinopathy (CSC) patients. The results showed a significant increase in photoreceptor outer segment surface area and choroidal thickness in the unaffected eyes.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Susana Penas, Teresa Araujo, Ana Maria Mendonca, Simao Faria, Jorge Silva, Aurelio Campilho, Maria Lurdes Martins, Vania Sousa, Amandio Rocha-Sousa, Angela Carneiro, Fernando Falcao-Reis
Summary: This study investigates the retinal and choroidal vascular reactivity to carbogen in patients with central serous chorioretinopathy (CSC). The results suggest that the vascular reactivity in the choroidal vessels of CSC patients is significantly higher compared to controls.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biochemical Research Methods
Bingjie Wang, Richard Brown, Jay Chhablani, Shaohua Pi
Summary: In this study, an algorithm was developed to register OCT scans of patients with CSCR without the need for prior layer segmentation, and to calculate three-dimensional structural change maps. This tool can aid in monitoring disease progression and treatment efficacy.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Multidisciplinary Sciences
Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Keiko Azuma, Ryo Obata, Rei Arasaki, Shouko Ikeda, Arisa Ito, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: Cigarette smoking is associated with increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may play an important role in modulating the disease. Age, SE, and past smoking history are key factors influencing SFCT.
Article
Ophthalmology
Pei Liu, Haixin Fang, Guangqi An, Bo Jin, Chenyu Lu, Shu Li, Fan Yang, Liping Du, Xuemin Jin
Summary: This study aimed to evaluate the characteristics of retina, choroid structure, and blood flow in elderly patients with chronic central serous chorioretinopathy (cCSC) through multimode imaging. The results suggest that elderly cCSC patients exhibit more severe structural damage and ischemia in the choroid and retina, and have a higher risk of developing choroidal neovascularization.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Dianlei Guo, Jiali Ru, Lijing Xie, Mingjuan Wu, Yingchun Su, Shiyong Zhu, Shujuan Xu, Bin Zou, Yanhong Wei, Xialin Liu, Yizhi Liu, Chunqiao Liu
Summary: The study discovered that Tmem138 plays a crucial role in the functional organization of photoreceptor connecting cilium (CC), which is essential for rhodopsin localization and outer segment (OS) biogenesis. Inactivation of Tmem138 leads to abnormal development of OS and degeneration of photoreceptor cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yihao Xia, Xiaodong Li, Jiaqi Zhang, Xuejun Xie
Summary: This study evaluated the choroidal vascularity index (CVI) in central serous chorioretinopathy (CSC) and found that CVI is increased in acute CSC eyes and fellow eyes. There was no significant difference in CVI between acute and chronic CSC eyes. The area selected for CVI calculation may influence the outcomes of the study and requires further research.
Article
Biochemistry & Molecular Biology
Young Ho Kim, Yoo-Ri Chung, Chungwoon Kim, Kihwang Lee, Won Ki Lee
Summary: This study investigated the relationship between pachydrusen and choroidal thickness and age in eyes with polypoidal choroidal vasculopathy (PCV) and eyes with central serous chorioretinopathy (CSC). The presence of pachydrusen was more frequent in PCV eyes compared to CSC eyes, and subfoveal choroidal thickness was associated with pachydrusen in PCV eyes while age was associated with pachydrusen in CSC eyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Joost Brinks, Elon H. C. van Dijk, Szymon M. Kielbasa, Hailiang Mei, Isa van der Veen, Hendrika A. B. Peters, Hetty C. M. Sips, Robbert G. E. Notenboom, Paul H. A. Quax, Camiel J. F. Boon, Onno C. Meijer
Summary: Glucocorticoid receptor plays a predominant role in mediating the response to cortisol in human choroidal endothelial cells (CECs). Interindividual differences are important determinants in the cortisol response of human cultured CECs, while intrinsic sex differences appear to be less pronounced. Target genes such as ZBTB16 show a marked response to cortisol in endothelial cells and may have a potential role in the pathophysiology of CSC and other vascular conditions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Ophthalmology
Spoorti Krishna Reddy Mandadi, Claudio Iovino, Riccardo Sacconi, Giuseppe Querques, Enrico Peiretti, Sumit Randhir Singh, Jay Chhablani
Summary: Outer retinal tubulations associated with choroidal neovascularisation in chronic central serous chorioretinopathy were found in 9.1% of eyes, with an average of 4.7 +/- 4.6 tubulations per eye. Spheroidal tubulations were more common than branching ones. Despite usually being associated with inactive disease, two eyes had coexistent subretinal fluid.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Yoo-Ri Chung, Su Jeong Lee, Ji Hun Song
Summary: We evaluated the effect of intravitreal bevacizumab injection on chronic central serous chorioretinopathy and found that it significantly improved visual acuity and central retinal thickness. Early changes in choroidal thickness were associated with the therapeutic response.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)