Article
Medicine, General & Internal
Yanyan Lin, Wei Gong, Jie Kang, Yuhong Fang, Jingjing Liu, Lihang Lin, Xuemin Xiao
Summary: The study concluded that the hemoporfin-mediated photodynamic therapy (HMME-PDT) is effective and safe for port-wine stains (PWS). Factors such as age, lesion distribution, and treatment history were found to influence treatment efficacy, with age being the most significant factor. Optical coherence tomography (OCT) was shown to be useful in objectively assessing the efficacy of HMME-PDT.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Defu Chen, Ying Wang, Hongyou Zhao, Haixia Qiu, Yongtian Wang, Jian Yang, Ying Gu
Summary: The study demonstrates that vascular targeted photodynamic therapy (V-PDT) is an effective treatment for port-wine stains, with the ability to monitor changes in oxygen saturation, blood volume fraction, and perfusion to understand the physiological mechanisms involved.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kai Chen, Yan-Yan Hu, Lin-Lin Wang, Yun Xia, Qian Jiang, Lan Sun, Shan-Shan Qian, Jin-Zhao Wu, Liu-Qing Chen, Dong-Sheng Li
Summary: This study identified two novel somatic mutations, KCNJ12 and SLC25A5, in sporadic PWS patients for the first time using whole-genome sequencing and whole-exome sequencing. These findings highlight the genetic polymorphism of PWS and provide potential clinical prediction targets for this disease.
FRONTIERS IN MEDICINE
(2022)
Article
Engineering, Biomedical
Marta Fusano, Pier Luca Bencini
Summary: This study described the capillaroscopic and reflectance confocal microscopy features of refractory port-wine stains, finding significant differences in RCM examination between different types of stains, which could be classified into three distinct patterns.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Engineering, Biomedical
Min Zhu, Jing Liu, Jun Zhou, Simeng Qiao, Zhaoyang Wang, Zhao Wang, Weihui Zeng
Summary: The study aimed to observe the influential factors for the efficacy of HMME-PDT in the treatment of PWS. Factors such as age, treatment sessions, lesion subtypes, and previous treatment history were found to be related to the response of HMME-PDT. Increasing treatment sessions and targeting lesion on maxillary prominence area and mandibular prominence area were positively correlated with higher efficacy.
LASERS IN MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Lian Liu, Xiaoxue Li, Qian Zhao, Lihua Yang, Xian Jiang
Summary: Port-wine stains (PWSs) are congenital vascular malformations involving skin and mucosa. The mechanisms behind their development and progression are still unclear. Possible causes include genetic mutations, decreased nerve elements, and cellular expression defects. While pulsed-dye laser (PDL) remains the gold standard treatment, recurrence rates are high. Topical drugs and photothermal therapy show promise in reducing recurrence and improving treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Spectroscopy
Rodrigo C. Silva, Hilde H. Buzza, Eli S. A. Ducas, Kleber T. Oliveira, Vanderlei S. Bagnato, Guilherme R. L. Souza, Luciane M. Almeida, Pablo J. Goncalves
Summary: A supramolecular assembly of methylene blue and curcumin was synthesized and evaluated for its potential in photodynamic antiangiogenic therapy. The results demonstrated that the MB-Curc assembly exhibited a synergistic vascular effect, causing significant damage to the vascular network after irradiation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Medicine, General & Internal
Ling Wang, Lei Li, Chao Huang
Summary: The present study conducted a systematic review and meta-analysis to evaluate the safety and effectiveness of photodynamic therapy (PDT) for port wine stains (PWS). The findings suggest that PDT is a safe and effective treatment for PWS, but more high-quality comparative studies are needed to strengthen this conclusion.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Yan-Yan Hu, Kai Chen, Lin-Lin Wang, Jia-Fang Wang, Xi Chen, Li-Juan Cao, Qian Jiang, Zhen-Xing Wang, Shan-Shan Qian, Zhi-Jun Chen, Liu-Qing Chen, Dong-Sheng Li
Summary: A study found that combining general anesthesia with PDT can improve the treatment efficacy for patients with port-wine stains, without significant impact on safety.
FRONTIERS IN MEDICINE
(2023)
Review
Dermatology
Ping Diao, Chenglong Han, Xiaoxue Li, Yi Yang, Xian Jiang
Summary: This article briefly reviews the mechanism, efficacy evaluation, effectiveness and influencing factors, as well as the common postoperative reactions and treatment suggestions of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in the treatment of port wine stain (PWS).
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Dermatology
Chloe J. Chua, Prabodh K. Pandey, Kristen M. Kelly, Liangzhong Xiang
Summary: This study investigates the feasibility of a hybrid treatment modality for port wine birthmark, combining photoacoustic (PA) guided ultrasound (US) focusing. The proposed methodology allows for selective targeting of the vasculature while minimizing damage to neighboring tissue.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Dermatology
Jie Kang, Jing-jing Liu, Yu-hong Fang, Yan-yan Lin, Wei Gong, Huai-yu Wang, Li-hang Lin, Xue-min Xiao
Summary: In this study, the clinical efficacy and safety of HMME-PDT for the treatment of PWSs on the extremities were evaluated. It was found that the therapeutic efficacy of HMME-PDT increased with the number of treatment sessions. Lesions located in proximal limbs and PWSs with specific vascular patterns under dermoscopy were associated with higher efficacy. HMME-PDT is a safe and effective treatment for PWSs on the extremities.
DERMATOLOGY AND THERAPY
(2023)
Review
Health Care Sciences & Services
Giacomo Colletti, Sara Negrello, Linda Rozell-Shannon, Gregory M. M. Levitin, Liliana Colletti, Luigi Chiarini, Alexandre Anesi, Mattia Di Bartolomeo, Arrigo Pellacani, Riccardo Nocini
Summary: This study evaluated the role of surgery in treating port-wine stains and found that surgery is effective for cases that do not respond to laser therapy or have tissue hypertrophy. Surgery can be used to correct facial asymmetry related to port-wine stains and achieve a more harmonious and predictable result.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Engineering, Environmental
Ziyong Li, Si Chen, Yurou Huang, Hui Zhou, Shuren Yang, Haining Zhang, Mingxing Wang, Hui Guo, Jun Yin
Summary: Researchers have developed a novel photosensitizer system that allows for reversible control over singlet oxygen generation. This photosensitizer exhibits excellent aggregation-induced emission properties and photoswitching behavior, making it suitable for precise photodynamic therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)