Article
Multidisciplinary Sciences
Antony R. Young, Kylie A. Morgan, Graham Harrison, Karl P. Lawrence, Bibi Petersen, Hans Christian Wulf, Peter A. Philipsen
Summary: The validity of the action spectrum for cutaneous synthesis of vitamin D3 has been questioned, with in vivo testing showing it does not accurately predict serum 25(OH)D3 levels. This suggests that previous risk/benefit analyses based on ex vivo data need revision.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Chao-Kai Hsu, Nan-Yu Cheng, Chao-Chun Yang, Yun-Yo Yen, Sheng-Hao Tseng
Summary: In clinical settings, there is a strong demand for more efficient and accurate methods to quantify the inflammation status of psoriatic lesions. This study used a diffuse reflectance spectroscopy (DRS) system to determine skin water-protein binding status and hemoglobin concentration, and found that it could provide a valuable addition to existing measurement systems for evaluating psoriasis severity.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Sandhya Rai, Gunjan Rai, Amod Kumar
Summary: Sunlight and daily UV exposure play a crucial role in the evolution of all forms of life, impacting the skin and gut microbiome, as well as human immune regulation. Understanding these relationships is essential for maintaining skin health.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Dermatology
Qingwen Li, Yujuan Xu, Hong Shu, Na Li, Hua Gu, Li He, Ying Tu
Summary: In this study, the possible factors inducing erythema of sensitive skin were preliminarily explained by evaluating facial erythematous reaction to lactic acid sting test and capsaicin test in subjects with sensitive skin.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Environmental Sciences
Zhao Duan, Xusheng Yan, Qiang Sun, Xuan Tan, Chenxi Dong
Summary: The electrical resistivity of loess is significantly influenced by water content and salt content, exhibiting an exponential relationship with water content and reaching its maximum conductivity when NaCl content reaches a certain level. The relationship between loess electrical resistivity and test frequency is nonlinear, with an increase in frequency leading to a decrease in resistivity. The three paths model and double-layer structure can explain the phenomena observed in the study.
ENVIRONMENTAL EARTH SCIENCES
(2021)
Article
Oncology
Sofiane Allali, Matthieu Carton, Thomas Sarrade, Ophelie Querel, Alexandra Jacquet, Sofia Rivera, Youssef Ghannam, Karine Peignaux, Philippe Guilbert, Claire Chara-Brunaud, Julien Blanchecotte, David Pasquier, Severine Racadot, Celine Bourgier, Alain Labib, Julien Geffrelot, Ahmed Benyoucef, Francois Paris, Paul Cottu, Fabrice Andre, Youlia Kirova
Summary: Skin damage is a common and important toxicity during and after radiation therapy. This study found associations between skin erythema and obesity, type of surgery, axillary dissection, taxane-based chemotherapy, and the irradiation technique. Risk factors for fibrosis included age at diagnosis, obesity, tobacco, and the use of a boost. The use of IMRT technique decreased the occurrence of skin erythema.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Dermatology
Duygu Erdil, Vildan Manav, Cemre B. Turk, Asude Kara Polat, Ayse E. Koku Aksu
Summary: This study investigates the impact of botulinum toxin injection on melanin levels in the skin. The results suggest that this injection can lighten the facial skin, with the forehead showing the most significant effect. Younger individuals may benefit more from this skin-lightening effect.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Thermodynamics
Lin Qiu, Sida Wang, Ziyang Wang, Yuhao Ma, Yanhui Feng
Summary: A conformal sensor-based harmonic wave technique has been developed to measure the water content in both epidermis and dermis, providing a more accurate method for diagnosing skin health status.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Review
Dermatology
K. A. Merin, Merin Shaji, R. Kameswaran
Summary: Skin acts as a barrier to protect the body from harmful effects of solar ultraviolet radiation. However, overexposure to UV radiation can lead to various skin diseases, including skin cancer and premature aging. Outdoor professionals and indoor tanning enthusiasts are particularly vulnerable to occupational or sun-induced skin diseases. Sunscreen is a crucial part of skin protection, along with other measures like wearing protective clothing and accessories.
INDIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemical Research Methods
Inga Saknite, Shinwho Kwun, Kathy Zhang, Alexis Hood, Fuyao Chen, Lauri Kangas, Pirjo Kortteisto, Ari Kukkonen, Janis Spigulis, Eric R. Tkaczyk
Summary: Hyperspectral imaging accurately distinguished the active erythema and post-inflammatory hyperpigmentation in chronic graft-versus-host-disease. The method was validated by dermatologist-approved confident delineations of affected and unaffected areas in photographs. The unsupervised extraction of unknown absorbers achieved a comparable accuracy to supervised extraction of known absorbers (melanin, hemoglobin) in delineating erythema and hyperpigmentation.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Medicine, Research & Experimental
Yuling L. Yang, Chu Zhou, Qi Chen, Shuzhan Z. Shen, Jiandan D. Li, Xiuli L. Wang, Peiru R. Wang
Summary: The lymphatic-centered immune microenvironment has adapted under continuous UVR via regulating YAP1/VEGFC and Piezo1. There are two turning points of lymphatic changes occurred during UV-induced cSCC formation. YAP1, Piezo1, LVs, and immune cells constantly changed with the skin state induced by UVR. According to these changes, the process of cSCC can be identified in advance and intervene timely.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Environmental
Celal Emre Uyeturk, Nejan Huvaj
Summary: The mechanical behavior of residual soils was studied through constant water content direct shear tests, revealing that shear strength increases with decreasing saturation and the relationship between shear strength and saturation is nonlinear. Additionally, a more dilative response was observed with decreasing saturation and applied normal stress.
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT
(2021)
Article
Medicine, General & Internal
Young Jae Kim, Ik Jun Moon, Hae Woong Lee, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Woo Jin Lee
Summary: This study evaluated the efficacy and safety of dual-frequency ultrasound with impulse mode for improving skin hydration and erythema in Asian subjects with rosacea and acne. The results showed a significant decrease in erythema index and transepidermal water loss, as well as improvements in clinician's erythema assessment and patient satisfaction. Dual-frequency ultrasound with impulse mode appears to be effective and safe for improving skin hydration and erythema in patients with rosacea and acne.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Chun-Wei Lu, Jong-Hwei Su Pang, Yu-Shien Ko, Chih-Jung Chang, Chuang-Wei Wang, Wei-Ti Chen, Chun-Bing Chen, Rosaline Chung-yee Hui, Shuen-Iu Hung, Lai-Ying Lu, Kun Lin Lu, Chih-Liang Wang, Chiao-En Wu, Ping-Chih Hsu, Yueh-Fu Fang, Shih-Hong Li, How-Wen Ko, Li-Chuan Tseng, Feng-Ya Shih, Mei-Jun Chen, Wen-Hung Chung
Summary: This study investigated the role of zinc deficiency in EGFR-TKI-induced skin toxicities and found that zinc supplementation can ameliorate skin impairment following EGFR-TKI therapy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biochemical Research Methods
Sergei A. Perkov, Dmitry A. Gorin, Rinat O. Esenaliev
Summary: Optoacoustic technique shows promise as an accurate and noninvasive tool for monitoring water content in the skin, with potential applications in dermatology, cosmetology, and tissue trauma management. By studying OA response across different skin layers, optimal wavelengths for water content monitoring were identified, indicating its potential as a valuable quantitative tool with high-resolution capabilities.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Dermatology
Vinzent Kevin Ortner, Walfre Franco, Merete Haedersdal, Peter Alshede Philipsen
Summary: The study evaluated the potential of a handheld u-FEI system as a practical screening tool for fungal nail infections. The results showed that the system could clearly differentiate between healthy and mycotic nail samples.
LASERS IN SURGERY AND MEDICINE
(2021)
Article
Dermatology
Vinzent K. Ortner, Jon Holmes, Merete Haedersdal, Peter A. Philipsen
Summary: This study evaluated the intermethod agreement, reliability, and technical limitations of WFM, OCT, and RCM for morphometry. Results showed varying levels of repeatability between methods and target measurements, with thickness measurements performed with calipers, WFM, and OCT demonstrating high intermethod agreement. OCT demonstrated the highest repeatability among all imaging techniques, with nail thickness showing the highest measurement reliability.
LASERS IN SURGERY AND MEDICINE
(2021)
Article
Dermatology
Vinzent Kevin Ortner, Victor Desmond Mandel, Merete Haedersdal, Peter Alshede Philipsen
Summary: This study compared the effects of an emollient and water on nail tissue imaging using optical coherence tomography (OCT). Results showed that emollient impregnation enhanced visualization of nail tissue without affecting caliper measurements, while hydration caused disagreements between caliper- and OCT-measured nail thickness. It is recommended to practice caution when hydrating nails for imaging purposes.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Article
Dermatology
C. S. K. Fuchs, V. K. Ortner, F. S. Hansen, P. A. Philipsen, M. Haedersdal
Summary: A-BPO treatment improves skin micromorphology of acne patients by reducing sebum secretion and hyperkeratinization while increasing epidermal thickness. However, these changes do not significantly affect transfollicular delivery of microparticles.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Chemistry, Medicinal
Hans Christian Wulf, Ida M. Heerfordt, Peter Alshede Philipsen
Summary: This study found that an activation of 50 PpIX units is sufficient for successful treatment of actinic keratoses, and that the red light illumination time can be shortened from 9 minutes to 1-2 minutes without compromising the therapeutic effect of PDT.
Article
Chemistry, Medicinal
Hans Christian Wulf, Rami Nabil Al-Chaer, Martin Glud, Peter Alshede Philipsen, Catharina Margrethe Lerche
Summary: In this study, methylene blue (MB) and riboflavin (RF) did not show significant effectiveness in preventing skin tumors induced by ultraviolet radiation, while methyl aminolevulinate (MAL) was proven to be an effective prophylactic treatment against UVR-induced skin tumors in hairless mice.
Article
Nutrition & Dietetics
Ida M. Heerfordt, Catharina M. Lerche, Peter A. Philipsen, Hans Christian Wulf
Summary: This study investigates the impact of recommendations and counseling on serum 25(OH)D levels in EPP patients, and compares the levels of 25(OH)D in patients with other populations.
Article
Allergy
Jette G. Skiveren, Malene F. Ryborg, Britt Nilausen, Susan Bermark, Peter A. Philipsen
Summary: Healthcare workers reported frequent adverse skin reactions while using face personal protective equipment during the COVID-19 pandemic. Factors such as chronic skin diseases and skin types influenced the occurrence of these reactions, with sensitive skin types being more prone. Daily long-term use of face protective equipment increased the risk of adverse skin reactions by four times.
CONTACT DERMATITIS
(2022)
Review
Dermatology
Vinzent Kevin Ortner, Victor Desmond Mandel, Serena Bertugno, Peter Alshede Philipsen, Merete Haedersdal
Summary: This study conducted non-invasive imaging techniques to detail the nail unit structures of psoriatic patients, reducing overall redundancy by unifying terminology and image feature descriptions. More than 75% of the identified image features provided additional disease-relevant information not captured by traditional clinical assessment scales.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Vinzent Kevin Ortner, Nhi Nguyen, Jonathan R. Brewer, Vita Solovyeva, Merete Haedersdal, Peter Alshede Philipsen
Summary: The study visualized the effects of laser ablation on nail tissue and assessed their impact on the biodistribution of a fluorescent dye in healthy and fungal nail tissue. The results showed that laser treatment significantly increased the penetration of the fluorescent dye into the nail plate.
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ida M. Heerfordt, Jeppe D. Andersen, Peter A. Philipsen, Linnea Langhans, Torben Tvedebrink, Grethe Schmidt, Thomas Poulsen, Catharina M. Lerche, Niels Morling, Hans Christian Wulf
Summary: This study aims to use RNA analysis to improve early diagnostic accuracy of suspicious lesions and enhance the management of CMM.
Article
Dermatology
Emily Wenande, Katrine Togsverd-Bo, Anna Hastrup, Ulrikke Lei, Peter A. Philipsen, Merete Haedersdal
Summary: This study aimed to identify risk factors for skin cancer development in solid organ transplant recipients (SOTRs). The results showed that a diagnosis of actinic keratosis (AK) was strongly associated with the development of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in SOTRs. Therefore, intensified skin cancer screening should be conducted in SOTRs with AK diagnosis.
Article
Biochemistry & Molecular Biology
Olivia Strunge Meyer, Mikkel Meyer Andersen, Claus Borsting, Niels Morling, Hans Christian Wulf, Peter Alshede Philipsen, Catharina Margrethe Lerche, Jeppe Dyrberg Andersen
Summary: This study compared the global DNA methylation levels of hairless mouse epidermis using the Infinium Mouse Methylation BeadChip and whole genome bisulphite sequencing (WGBS). The results showed a strong correlation between the DNA methylation levels obtained from both methods and suggested that fresh and fresh-frozen samples can be used interchangeably. The choice of method will depend on the specific study's aims and laboratory resources.
Review
Dermatology
Ida M. Heerfordt, Peter A. Philipsen, Catharina M. Lerche, Hans Christian Wulf
Summary: Severe skin pain from long wave ultraviolet radiation or visible light exposure is the main symptom of erythropoietic protoporphyria (EPP). Current treatment options are insufficient and new treatments are hindered by the lack of valid efficacy outcomes. This study provides an overview of phototest procedures used to evaluate EPP treatments. The protocols varied extensively in illumination set-up and evaluation of phototest reactions, highlighting the need for a standardized phototest method for future protoporphyric photosensitivity research.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Construction & Building Technology
A. R. Webb, I. P. Terenetskaya, M. F. Holick, A. van Dijk, R. L. McKenzie, R. M. Lucas, A. R. Young, P. A. Philipsen, F. R. de Gruijl
Summary: In 2006, CIE published a technical report on the action spectrum for the production of previtamin D-3 in human skin. The report has been widely used for 15 years and has been challenged several times. However, no alternative action spectrum has shown clear advantages over the CIE version. A CIE workshop concluded that the CIE action spectrum may need to be amended, but until a clear alternative is found, the CIE action spectrum should continue to be used.
LIGHTING RESEARCH & TECHNOLOGY
(2023)