Review
Biotechnology & Applied Microbiology
Peter Setlow, Graham Christie
Summary: Spores can spread food spoilage, diseases, and intoxications, and methods for spore killing include heat, radiation, high pressure, and chemicals. Factors to consider in choosing methods for spore killing include cost, efficacy, operation scope, and compatibility.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leon G. Leanse, Xiaojing Zeng, Tianhong Dai
Summary: The study investigated the antimicrobial capabilities of the innovative combination of antimicrobial blue light (aBL) with Pseudomonas aeruginosa pigment pyocyanin against methicillin resistant Staphylococcus aureus (MSRA). The results showed that pyocyanin potentiated aBL activity and could bleach staphyloxanthin within MRSA colonies, significantly reducing MRSA viability in a proof-of-principle early onset MRSA skin abrasion infection model. The combination of aBL and pyocyanin represents a potentially powerful therapeutic modality for the treatment of MRSA infections.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Review
Immunology
Linhai Zhang, Lijia Zhang, Fangjing Li, Wanyu Liu, Zhenzhen Tai, Juan Yang, Haiqing Zhang, Jinmei Tuo, Changyin Yu, Zucai Xu
Summary: Herpes simplex virus (HSV) is the most common cause of infectious encephalitis, accounting for nearly half of the confirmed cases. Clinical symptoms of HSV encephalitis are often atypical. HSV PCR in cerebrospinal fluid aids in diagnosis, and prognosis is usually favorable with regular antiviral treatment. Interestingly, some patients with recurrent encephalitis show little antiviral response. HSV PCR in cerebrospinal fluid is negative, but glucocorticoids have a significant effect after treatment. Specific antibodies, such as NMDA receptor antibody and GABA receptor antibody, can be found in the cerebrospinal fluid, suggesting the involvement of the immune system in recurrent encephalitis, although the specific mechanism remains unclear. Based on recent studies, we aim to summarize the relationship between herpes simplex encephalitis and innate immunity, providing further insights for researchers in this field.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Peter Setlow, Graham Christie
Summary: Spores formed by some Firmicutes members exemplify the quest for bacterial survival, as they are ubiquitous and reflect adaptations to bacteria's stresses. Spores have significant impact in public health, food safety, and biowarfare. Their heat resistance, conferred by a mineralized protoplast and reduced water content, is hallmark, while mutations may arise from dry heat exposure. Their multifactorial countermeasures to extreme conditions involve reduced macromolecular motion and DNA saturation with small acid-soluble spore proteins (SASPs). SASPs also contribute to radiation resistance, along with Ca2+, photoproduct lyase, and low water content, minimizing DNA damage. Spores' resistance extends to chemicals and macromolecules, facilitated by the spore coat, inner membrane, and SASP protection. Other stresses, such as high pressure and abrasion, are also resisted. Overall mechanisms of resistance involve reduced molecular motion, a balance between rigidity and flexibility, and efficient repair.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Article
Immunology
Joe James, Stephanie M. Meyer, Huynh A. Hong, Chau Dang, Ho T. Y. Linh, William Ferreira, Paidamoyo M. Katsande, Linh Vo, Daniel Hynes, William Love, Ashley C. Banyard, Simon M. Cutting
Summary: This study found that nasal dosing using heat-stable spores can reduce clinical symptoms of influenza infection and decrease viral shedding in animals. This approach may have important implications for influenza prophylaxis in both humans and animals.
Article
Acoustics
Xiaolin Zhu, Han Yan, Zhenkun Cui, Hongbo Li, Wei Zhou, Zhenbin Liu, Hao Zhang, Tatiana Manoli, Haizhen Mo, Liangbin Hu
Summary: This study investigates the bactericidal effect of blue light (BL) on Vibrio parahaemolyticus and evaluates the combination of ultrasonic field (UF) treatment with BL for enhanced bactericidal effectiveness. The results show that BL irradiation can effectively cause cell death and shrinkage in V. parahaemolyticus, and UF treatment enhances the bactericidal effect of BL. However, it is important to strictly control the intensity of BL and the duration of UF treatment to prevent negative impact on the freshness and color of the salmon.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Optics
Wenshuai Zhang, Yongsheng Wang, Dingyu Xu, Hailu Luo
Summary: This study investigates the spin-orbit interaction of a vortex beam reflected on twisted few-layer hyperbolic metasurfaces. The spatial Imbert-Fedorov (IF) shift and photonic spin Hall effect (PSHE) shift are found to have symmetrical relationships with the twist angle and are influenced by the topological charge and the polarization state of the incident beam. These findings provide new insights for further investigations of twisted light and twisted metasurfaces.
Article
Physics, Condensed Matter
C. S. Velez-Saboya, J. R. Guzman-Sepulveda, J. C. Ruiz-Suarez
Summary: Phase transitions of liposomes can be studied using differential scanning calorimetry. When the temperature changes, liposomes transition from a gel to a liquid phase or from a liquid to a gel phase, accompanied by changes in their size.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2022)
Article
Psychology, Multidisciplinary
Shin- Shih, Nai-Wen Chi, Chi-Cheng Wu, Shao-Ying Wang
Summary: The study found that Dark Triad personality traits have an impact on depression, and the relationships between each trait and depressive symptoms were different.
CURRENT PSYCHOLOGY
(2021)
Article
Construction & Building Technology
M. J. Ertelt, Lea Bubendorfer, C. U. Grosse, O. Lieleg
Summary: Biological additives have gained attention in the past decade as admixtures to cement based materials, with bacterial additives showing potential in improving properties. However, the production process of most bacterial additives is time-consuming and expensive. Research reveals that selected bacterial spores can enhance water-resistance of mortar, yet the overall performance of resulting hybrid material is still inferior to other bacterial additives.
CEMENT & CONCRETE COMPOSITES
(2021)
Article
Economics
Reda Cherif, Fuad Hasanov
Summary: This article provides economic theories and evidence regarding development miracles and growth failures, suggesting that high growth depends on maintaining optimal policies and highlighting the value of growth miracles compared to growth failures.
STRUCTURAL CHANGE AND ECONOMIC DYNAMICS
(2024)
Article
Engineering, Electrical & Electronic
Mohamed Elsayed, Ahmad Samir, Ahmad A. Aziz El-Banna, Xingwang Li, Basem M. ElHalawany
Summary: This paper analyzes the performance of a symbiotic-radio AmBC system based on NOMA multiplexing, and verifies the analysis results through mathematical derivation and simulations. The research results show that the system has good diversity and low outage probability under Nakagami-m fading channels, and can achieve outage-optimal performance through power allocation optimization.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Donald A. Schupp, Adam C. Burdsall, Rendahandi G. Silva, John Lee Heckman, E. Radha Krishnan, Jeffrey G. Szabo, Matthew Magnuson
Summary: This study compares the persistence of different pathogens in a wastewater treatment system. The results show that the duration of persistence varies for different pathogens, which has implications for consequence management actions.
Article
Biophysics
Leslie K. Daille, Javiera Aguirre, Javiera Anguita, Carlos Galarce, Luis Caro-Lara, Francisco Armijo, Ignacio T. Vargas, Gonzalo Pizarro, Magdalena Walczak, Rodrigo De la Iglesia
Summary: The composition of the passive film on alloys affects the selection of microbial biofilms, but the mechanism is not fully understood or incorporated into the analysis of corrosive biofilms. The degradation of stainless steel exposed to natural seawater was studied to investigate how the oxide layer composition influences the bacterial community. Austenitic and superferritic stainless steel grades were exposed to natural seawater, and the corrosion and biofilm formation were monitored. Bacterial communities were analyzed through massive sequencing, and the results showed that the similarity of bacterial community correlated with the variability of corrosion rate, with higher representation of certain bacterial families in stainless steels with an increased Fe/Cr ratio. Iron content in the oxide layer is found to be a key feature in selecting bacterial assemblages in marine environments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Medicinal
Zhihua Wang, Qiuke Li, Jinze Li, Lu Shang, Jiawei Li, Shuli Chou, Yinfeng Lyu, Anshan Shan
Summary: This study synthesized a series of pH-responsive antimicrobial peptides, among which F5 exhibited outstanding pH-responsive activity and low toxicity. It killed bacteria through a membrane-disruptive mechanism at acidic pH values and showed excellent therapeutic ability in a mouse abscess model.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Psychiatry
Masoumeh Beheshti, Nikta Rabiei, Mohammad Taghizadieh, Pariya Eskandari, Samaneh Mollazadeh, Ehsan Dadgostar, Michael R. Hamblin, Arash Salmaninejad, Raziye Emadi, Amir Hossein Mohammadi, Hamed Mirazei
Summary: Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder characterized by intrusive thoughts and repetitive or ritualized actions. It is believed to have a genetic component, but the specific genetic factors involved are still unknown. This review summarizes the single nucleotide polymorphisms associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information can help to understand the genetic basis of OCD, characterize individual patients, predict prognosis, and develop personalized treatment approaches.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Spectroscopy
Faezeh Fallahi, Atarodalsadat Mostafavinia, Zahranadia Sharifi, Leila Mohaghegh Shalmani, Abdollah Amini, Houssein Ahmadi, Hamidreza Omidi, Masoumeh Hajihosseintehrani, Sahar Bayat, Michael R. Hamblin, Sufan Chien, Mohammad Bayat
Summary: This study reports the effects of photobiomodulation (PBM) on diabetic adipose-derived stem cells (ADSCs) in vitro. The results showed that PBM significantly increased ATP levels and mitochondrial membrane potential (MMP), while decreasing reactive oxygen species (ROS) levels and the expression of PINK1 and PARKIN genes in diabetic-ADSCs. These findings suggest that PBM has the potential to improve the function and quality of mitochondrial diabetic-ADSCs, making it a promising approach for treating diabetic foot ulcers in diabetic patients.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Ali Arash Anoushirvani, Arezoo Jafarian Yazdi, Sanaz Amirabadi, Sahar Ahmadi Asouri, Rana Shafabakhsh, Amirhossein Sheida, Maryam Sadat Hosseini Khabr, Ameneh Jafari, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Leila Kalantari, Sayyed Alireza Talaei Zavareh, Hamed Mirzaei
Summary: Neuroblastoma is the most common extracranial malignancy in childhood and is derived from neural crest. Non-coding RNAs (ncRNAs) have been found to play important roles in various cancers, including glioma and gastrointestinal cancers, by regulating cancer gene networks. Recent studies have shown that ncRNA genes are deregulated in human cancers through various mechanisms, and disturbances in their expression can act as either oncogenes or tumor suppressor genes, leading to the development of cancer. Moreover, ncRNAs can be secreted from tumor cells in exosomes and transferred to other cells, exerting their functions. However, further research is needed to fully understand the roles of ncRNAs in neuroblastoma.
CANCER GENE THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Nasim Ebrahimi, Elmira Fardi, Hajarossadat Ghaderi, Sahar Palizdar, Roya Khorram, Reza Vafadar, Masoud Ghanaatian, Fatemeh Rezaei-Tazangi, Payam Baziyar, Amirhossein Ahmadi, Michael R. Hamblin, Amir Reza Aref
Summary: Targeted therapy is a new approach in cancer treatment, using drugs that specifically target proteins in cancer cells. Inhibiting these proteins can impede cancer progression. Understanding the structures, activation mechanisms, and functions of receptor tyrosine kinases (RTKs) has led to the development of targeted drug therapies, including RTK inhibitors (RTKIs), some of which have been used in clinical settings. This article discusses RTKs and their role in cancer treatment, as well as the potential effects of combination drug therapy for drug resistant cancers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Irina Pereira, Carina Monteiro, Miguel Pereira-Silva, Diana Peixoto, Claudia Nunes, Salette Reis, Francisco Veiga, Michael R. Hamblin, Ana Claudia Paiva-Santos
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Infectious Diseases
Amir Hossein Miri, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Abbas Yadegar, Maryam Banar, Michael R. Hamblin, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
Summary: In this article, the conventional antibiotic treatment regimens for Helicobacter pylori are described, including empirical, tailored, and salvage therapies. The reasons for treatment failure against H. pylori are discussed, followed by the latest advances in the use of probiotic bacteria against H. pylori infection. Finally, a polymeric bio-platform for efficient delivery of probiotics for H. pylori infection is proposed.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Biochemical Research Methods
Clara Maria Cobra Branco Scontri, Flavio de Castro Magalhaes, Ana Paula Moraes Damiani, Michael R. Hamblin, Antonio Roberto Zamuner, Cleber Ferraresi
Summary: PBMt has a time- and dose-response effect to reduce glycemia in T2DM patients. The best dose is 100 J, which can lower blood glucose levels and persist until 12 hours. Combination with oral hypoglycemic medication can further improve glycemic control, but also increase sympathetic activation.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Chemistry, Physical
Houra Nekounam, Javad Malakootikhah, Donya Shaterabadi, Babak Negahdari, Mohammad Reza Kandi, Michael R. Hamblin
Summary: This article summarizes the advances in the preparation, optimization, and applications of silica nanoparticles in biomedical nanotechnology, as well as the inevitable human, environmental, and industrial contacts with these particles. Understanding the physicochemical properties of silica nanoparticles and their interactions with biological systems at the cellular level is crucial for the rational design of these particles. Control of toxicity risk can guide the design of silica nanoparticles for drug delivery and bioimaging systems.
Review
Microbiology
Weitao Zhu, Michael R. Hamblin, Xiang Wen
Summary: Rosacea is a chronic inflammatory skin disorder affecting the centrofacial region. Its etiology and treatment methods are still unclear. This review examines common bacterial species found in the skin and gut microbiota of rosacea patients and their role in pathogenesis. Additionally, it summarizes the impact of factors such as temperature and age on rosacea and reviews commonly used clinical treatment methods, including antibiotics and probiotics, along with their mechanisms and precautions.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Mohammad Varzandeh, Leila Sabouri, Vahid Mansouri, Maliheh Gharibshahian, Nima Beheshtizadeh, Michael R. Hamblin, Nima Rezaei
Summary: Radiosensitizers are compounds or nanostructures that enhance the effectiveness of ionizing radiation in killing cells. They increase the susceptibility of cancer cells to radiation-induced killing while minimizing damage to healthy tissues. This review discusses various nano-radiosensitizers and their combinations with other cancer therapies, highlighting the benefits, drawbacks, challenges, and future prospects.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Neurosciences
James C. Lech, Matthew T. J. Halma, Adejoke O. Obajuluwa, Malcolm Baker, Michael R. Hamblin
Summary: The impact of lighting environment in educational institutions on student biology has not received much attention. The current lighting environment in schools is not conducive to student health and educational performance. Cost-effective interventions can significantly improve student health and educational attainment. We strongly recommend that educational institutions consider the lighting environment when designing educational programs.
ANNALS OF NEUROSCIENCES
(2023)
Article
Engineering, Biomedical
Fahimeh Ghasemi Moravej, Abdollah Amini, Reza Masteri Farahani, Samira Mohammadi-Yeganeh, Atarodalsadat Mostafavinia, Houssein Ahmadi, Hamidreza Omidi, Fatemehalsadat Rezaei, Latif Gachkar, Michael R. Hamblin, Sufan Chien, Mohammad Bayat
Summary: Diabetic wounds lead to chronic inflammation and the development of diabetic foot ulcers, which can cause amputation and death. This study examined the effect of photobiomodulation (PBM) plus allogeneic diabetic adipose tissue-derived stem cells (ad-ADS) on wound healing in type I diabetic rats. The results showed that the ad-ADS plus PBM treatment group had significantly better histological results compared to the other experimental groups.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Engineering, Biomedical
Atousa Janzadeh, Fatemeh Ramezani, Sogol Yousefi, Michael R. Hamblin, Negin Mojarad, Farinaz Nasirinezhad
Summary: Neuropathic pain following spinal cord injury is a long-lasting condition that reduces the quality of life. Photobiomodulation therapy has shown some progress in treating this type of pain. In this study, two PBMT protocols were compared, and the 4-week protocol was found to be more effective in improving pain and disability. PBMT therapy modulates immune system function to reduce neuropathic pain and motor dysfunction.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Thomas Willmott, Gavin Humphreys, Krista Chappell-Jones, Mark Dickinson, Jian R. Lu, Michael R. Hamblin, Paul Dark, Andrew J. McBain
Summary: The antibacterial effects of a polychromatic light device designed for intravenous application were assessed in vitro. Exposure to a 60-min sequential light cycle comprising 365, 530, and 630 nm wavelengths resulted in small but statistically significant reductions in viable counts for Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Bacterial inactivation occurred only with red (630 nm) light, possibly mediated by reactive oxygen species generated by excitation of haem groups.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
